MicroRNAs and ischemic heart disease: Towards a better comprehension of pathogenesis, new diagnostic tools and new therapeutic targets

Recent Patents on Cardiovascular Drug Discovery

Volumn 4, Issue 2, 2009, Pages 109-118

  Silvestri, Pasquale ^a   Di Russo, Cristian ^a   Rigattieri, Stefano ^a   Fedele, Silvio ^a   Todaro, Daniel ^a   Ferraiuolo, Giuseppe ^a   Altamura, Giuliano ^a   Loschiavo, Paolo ^a  

^a SANDRO PERTINI HOSPITAL   (Italy)

Author keywords

Cardiac arrhythmias and post angioplasty restenosis; Heart failure; Ischemic heart disease; MicroRNA; Myocardial infarction; RNA interference; RNA based therapies

Indexed keywords

C REACTIVE PROTEIN; MICRORNA; MICRORNA 1; MICRORNA 126; MICRORNA 133; MICRORNA 208; MICRORNA 21; MICRORNA 210; MICRORNA 27; MICRORNA 29; MICRORNA 7; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; SMALL INTERFERING RNA;

ANGIOGENESIS; DIABETES MELLITUS; ENZYME ASSAY; GENE EXPRESSION PROFILING; GENE SEQUENCE; GENE TARGETING; HEART ARRHYTHMIA; HEART INFARCTION; HIGH THROUGHPUT SCREENING; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; MICROARRAY ANALYSIS; NORTHERN BLOTTING; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RISK FACTOR; RNA INTERFERENCE; RNA PRIMED ARRAY BASED KLENOW ENZYME ASSAY; SERIAL ANALYSIS OF GENE EXPRESSION; SMOKING; TRANSLUMINAL CORONARY ANGIOPLASTY; ANIMAL; BIOSYNTHESIS; GENE SILENCING; GENE THERAPY; GENETICS; HEART MUSCLE ISCHEMIA; METABOLISM; PHYSIOLOGY;

ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; ANIMALS; ARRHYTHMIAS, CARDIAC; GENE SILENCING; GENE THERAPY; HUMANS; MICRORNAS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; RNA, SMALL INTERFERING;

EID: 70149121045     PISSN: 15748901     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489009788452977     Document Type: Review

References (60)

1. Latronico MVG, Catalucci D, Condorelli G. Emerging role of microRNAs in cardiovascular biology. Circ Res 2007; 101: 1225-1236.
2. Wang Z, Luo X, Lu Y, Yang B. MiRNAs at the heart of matter. J Mol Med 2007; 86(7): 771-783.
3. Zhang C. MicroRNAs: Role in cardiovascular biology and disease. Clin Sci 2008; 114: 699-706.
4. Van Rooij E, Marshall WS, Olson EN. Toward microRNAs based therapeutics for heart disease. The sense in antisense. Circ Res 2008; 103: 919-928.
5. Divakaran V, Mann DL. The emerging role of microRNAs in cardiac remodeling and heart failure. Circ Res 2008; 103: 1072-1083.
6. Ambros V. A hierarchy of regulatory genes controls a larva-to-adult developmental switch in C. elegans Cell 1989; 57: 49-57.
7. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-854.
8. Lee Y, Kim M, Han J, et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J 2004; 23: 4051-4060.
9. Borchert GM, Lanier W, Davidson BL, et al. RNA polymerase III transcribes human microRNAs. Nat Struct Mol Biol 2006; 13: 1097-1101.
10. Landthaler M, Yalcin A, Tuschl T, et al. The human DiGeorge syndrome critical region gene 8 and its melanogaster homolog are required for miRNA biogenesis. Curr Biol 2004; 14: 2162-2167.
11. Kim VN. MicroRNA precursors in motion: Exportin-5 mediates their nuclear export. Trends Cell Biol 2004; 14: 156-159.
12. Peters L, Meister G. Argonaute proteins: Mediators of RNA silencing. Mol Cell 2007; 26: 611- 623.
13. Filipowicz W, Bhattacharrya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genetics 2008; 9: 102-114.
14. Tay Y, Zhang J, Thomson AM, Lim B, Rigoutsos I. MicroRNAs to Nanog, OCT and Sox2 coding regions modulate embryonic stem cell differentiation. Nature 2008; 455: 1124-1128.
15. Kedde M, Strasser MJ, Bolbajipour B, et al. RNA binding protein Dnd1 inhibits microRNA access to target mRNA. Cell 2007; 131: 1273-1286.
16. Vasudevan S, Tong Y, Steitz JA. Switching from repression to activation: MicroRNAs can up-regulate translation. Science 2007; 318: 1931-1934.
17. Hwang HW, Wentzel EA, Mendell JT. A hexanucleotide element directs microRNA nuclear import. Science 2007; 315: 97-99.
18. Valadi H, Ekstrom K, Bossios A, et al. Exosome mediated transfer of mRNAs and microRNAs is a novel mechamism of genetic exchange between cells. Nat Cell Biol 2007; 9: 654-659.
19. Soifer HS, Rossi JJ, Saetrom P. MicroRNAs in disease and potential therapeutic applications. Mol Ther 2007; 15: 2070-2079.
20. Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambrose V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol 2004; 5: R13.
21. Liu CG, Calin GA, Meloon B, et al. An oligonucleotide microchip for genome wide microRNA profiling in human and mouse tissues. Proc Natl Acad Sci USA 2004; 101: 9740-9744.
22. Brown, D., Conrad, R., Devroe, E., Goldrick, M., Keiger, K., Labourier, E., Moon, I., Powers, P., Shelton, J., Shingara. J.: US20080182245A1 (2008).
23. Brown, D., Conrad, R., Devroe, E., Goldrick, M., Keiger, K., Labourier, E., Moon, I., Powers, P., Shelton, J., Shingara. J.: US20080171667 (2008).
24. Latham, G.J., Kemppainen, J.: US20080131878A1 (2008).
25. Latham, G.J., Kemppainen, J.: WO2008070675A2 (2008).
26. Ikeda S, Kong SW, Lu J, et al. Altered microRNA expression in human heart disease. Physiol Genomics 2007; 31: 367-373.
27. Ikeda, S.: WO2008042231 (2008).
28. Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-811.
29. Morrisey, D., Mcswiggen, J., Beigelman, L.: US20080161256A1 (2008).
30. Haeberly, P., Beigelman, L.: US20080249294A1 (2008).
31. Grunweller A, Hartmann RK. Locked nucleic acid oligonucleotides: The next generation of antisense agents? BioDrugs 2007; 21: 235-243.
32. Brown, D., Ford, L., Cheng, A., Jarvis, R., Bjrom, M., Ovcharenko, D., Devroe, E., Kelnar, K.: US20080171715 (2008).
33. Chen, T., Vargeese, C., Vagle, K., Wang, W., Zhang, Y.: US20080188675 (2008).
34. Grimm D, Streetz KL, Jopling CL, et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 2006; 441: 537-541.
35. Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with "Antagomirs". Nature 2005; 438: 685-689.
36. Brown, D., Ford, L., Cheng, A., Jarvis, R., Byrom, M., Ovcharenko, D., Devroe, E., Keinar, K.: US20080176766A1 (2008).
37. Ridker PM, Libby P. In: Braunwald's Heart Disease, a textbook of cardiovascular medicine 7th ed. Philadelphia, Elsevier Saunders 2005: 939-958.
38. Mcswiggen, J., Jadhav, V., Vaish, N., Guerciolini, R., Vargeese, C.: US20080249040A1 (2008).
39. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med 2007; 357: 1121-1135.
40. Lieberman, J., Hamar, P., Song, E.: US20080227733A1 (2008).
41. van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008; 105: 13027-13032.
42. Wang J, Xu R, Lin F, et al. MicroRNA: Novel regulators involved in the remodeling and reverse remodeling of the heart. Cardiology 2009; 113: 81-88.
43. Thum T, Gross C, Fiedler J, et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 2008 (Epub ahead of print).
44. van Rooij E, Sutherland LB, Qi X, Richardson JA, Hill J, Olson EN. Control of stress dependent cardiac growth and gene expression by a microRNA. Science 2007; 316: 575-579.
45. Yang B, Lin H, Xiao J, et al. The muscle specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 2007; 13: 486-491.
46. Smith SC, Feldman TE, Hirshfeld JW, et al. ACC/AHA/SCAI 2005 Guideline Update for Percutaneous Coronary Intervention - Summary Article. ACC/AHA/SCAI 2005 Guidelines update for percutaneous coronary intervention. Circulation 2006; 113: 156-175.
47. Ji R, Cheng Y, Rue J, et al. MicroRNA expression signature and antisense-mediated depletion reveal an essential role of microRNA in vascular neointimal lesion formation. Circ Res 2007; 100: 1579-1588.
48. Silvestri P, Rigattieri S, Loschiavo P. Does the effect of microRNAs on vascular neointimal formation depend on cell cycle phase? Circ Res 2008; 102(9): e101-e102.
49. Cheng Y, Liu X, Yang J, et al. The effects of some microRNAs in vascular neointimal formation may depend on celle cycle phase. Circ Res 2008; 102: e102.
50. Vanoverschelde JL, Wijns W, Depre C, et al. Mechanisms of chronic regional postischemic dysfunction in humans: New insights from the study of nonifarcted collateral-dependent myocardium. Circulation 1993; 87: 1513-1523.
51. Kuehbacher A, Urbich C, Zeiher AM, Dimmeler S. Role of Dicer and Drosha for endothelial MicroRNA expression and angiogenesis. Circ Res 2007; 101: 59-68.
52. Wang S, Aurora AB, Johnson BA, et al. The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Develop Cell 2008; 15: 261-271.
53. Fasanaro P, D'Alessandra Y, Di Stefano V, et al. MicroRNA-219 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine-kinase ligand Ephrin A3. J Biol Chem 2008; 283: 15878-15883.
54. Beltrami AP, Urbanek K, Kajstura J, et al. Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 2001; 344: 17590-17597.
55. Quaini F, Urbanek K, Beltrami AP, et al. Chimerism of the transplanted heart. N Engl J Med 2002; 346: 5-15.
56. Beltrami AP, Barlucchi L, Torella D, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003; 114: 763-776.
57. Leri A, Kajstura J, Anversa P, Frishman WH. Myocardial regeneration and stem cell repair. Curr Probl Cardiol 2008; 33: 91-153.
58. Ivey KN, Muth A, Arnold J, et al. MicroRNA regulation of cell lineages in mouse and human embrionic stem cells. Cell Stem Cell 2008; 2: 219-229.
59. Ray, S.: US20080233090 (2008).
60. Libby P, Ridker PM. Inflammation and atherosclerosis: Role of Creactive protein in risk assessment. Am J Med 2004; 116: 9S-16S.