Negative regulators of insulin signaling revealed in a genome-wide functional screen

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Huang, Shih Min A ^a,c   Hancock, Michael K ^a,d   Pitman, Jeffrey L ^b   Orth, Anthony P ^a   Gekakis, Nicholas ^b  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^d INVITROGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; INSULIN; INSULIN RECEPTOR; PALADIN; PROTEIN KINASE B; REGULATOR PROTEIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; PALADIN PROTEIN, HUMAN; PROTEIN;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; GENE REPRESSION; GENOME ANALYSIS; INSULIN RESISTANCE; NONHUMAN; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; ANIMAL; CRICETULUS; GENE EXPRESSION REGULATION; GENE LIBRARY; HAMSTER; HUMAN; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PHOSPHORYLATION; PHYSIOLOGY;

PALADIN;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DIABETES MELLITUS, TYPE 2; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; GENE LIBRARY; GENES, REPORTER; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; PHOSPHORYLATION; PROTEINS; SIGNAL TRANSDUCTION;

EID: 70149086498     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006871     Document Type: Article

References (28)

1. White MF (2003) Insulin signaling in health and disease. Science 302: 1710-1711.
2. Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, et al. (2005) IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med 11: 191-198.
3. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, et al. (1999) Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283: 1544-1548.
4. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, et al. (2005) Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol 25: 2498-2510.
5. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, et al. (2004) Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A 101: 2082-2087.
6. Du K, Herzig S, Kulkarni RN, Montminy M (2003) TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science 300: 1574-1577.
7. Schmoll D, Walker KS, Alessi DR, Grempler R, Burchell A, et al. (2000) Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity. J Biol Chem 275: 36324-36333.
8. Vander Kooi BT, Streeper RS, Svitek CA, Oeser JK, Powell DR, et al. (2003) The three insulin response sequences in the glucose-6-phosphatase catalytic subunit gene promoter are functionally distinct. J Biol Chem 278: 11782-11793.
9. Barthel A, Schmoll D, Unterman TG (2005) FoxO proteins in insulin action and metabolism. Trends Endocrinol Metab 16: 183-189.
10. Wick KR, Werner ED, Langlais P, Ramos FJ, Dong LQ, et al. (2003) Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor. J Biol Chem 278: 8460-8467.
11. Ono H, Katagiri H, Funaki M, Anai M, Inukai K, et al. (2001) Regulation of phosphoinositide metabolism, Akt phosphorylation, and glucose transport by PTEN (phosphatase and tensin homolog deleted on chromosome 10) in 3T3-L1 adipocytes. Mol Endocrinol 15: 1411-1422.
12. Brachmann SM, Ueki K, Engelman JA, Kahn RC, Cantley LC (2005) Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol Cell Biol 25: 1596-1607.
13. Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, et al. (1999) Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res 6: 337-345.
14. Alonso A, Sasin J, Bottini N, Friedberg I, Osterman A, et al. (2004) Protein tyrosine phosphatases in the human genome. Cell 117: 699-711.
15. Berglund L, Bjorling E, Oksvold P, Fagerberg L, Asplund A, et al. (2008) A genecentric Human Protein Atlas for expression profiles based on antibodies. Mol Cell Proteomics 7: 2019-2027.
16. Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, et al. (2002) Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proc Natl Acad Sci U S A 99: 419-424.
17. Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, et al. (1998) PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. Embo J 17: 3858-3866.
18. Vigliotta G, Miele C, Santopietro S, Portella G, Perfetti A, et al. (2004) Overexpression of the ped/pea-15 gene causes diabetes by impairing glucos-estimulated insulin secretion in addition to insulin action. Mol Cell Biol 24: 5005-5015.
19. Tu Y, Liang L, Frank SJ, Wu C (2001) Src homology 3 domain-dependent interaction of Nck-2 with insulin receptor substrate-1. Biochem J 354: 315-322.
20. Cai D, Dhe-Paganon S, Melendez PA, Lee J, Shoelson SE (2003) Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5. J Biol Chem 278: 25323-25330.
21. Xu H, Yang Q, Shen M, Huang X, Dembski M, et al. (2005) Dual specificity MAP kinase phosphatase 3 activates PEPCK transcription and increases gluconeogenesis in rat hepatoma cells. J Biol Chem.
22. Xu H, Dembski M, Yang Q, Yang D, Moriarty A, et al. (2003) Dual specificity mitogen-activated protein (MAP) kinase phosphatase-4 plays a potential role in insulin resistance. J Biol Chem 278: 30187-30192.
23. Asada S, Daitoku H, Matsuzaki H, Saito T, Sudo T, et al. (2007) Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1. Cell Signal 19: 519-527.
24. Kaartinen V, Gonzalez-Gomez I, Voncken JW, Haataja L, Faure E, et al. (2001) Abnormal function of astroglia lacking Abr and Bcr RacGAPs. Development 128: 4217-4227.
25. Tan EC, Leung T, Manser E, Lim L (1993) The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins. J Biol Chem 268: 27291-27298.
26. Chuang TH, Xu X, Kaartinen V, Heisterkamp N, Groffen J, et al. (1995) Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family. Proc Natl Acad Sci U S A 92: 10282-10286.
27. Cho YJ, Cunnick JM, Yi SJ, Kaartinen V, Groffen J, et al. (2007) Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages. Mol Cell Biol 27: 899-911.
28. Zeller C, Hinzmann B, Seitz S, Prokoph H, Burkhard-Goettges E, et al. (2003) SASH1: a candidate tumor suppressor gene on chromosome 6q24.3 is downregulated in breast cancer. Oncogene 22: 2972-2983.