Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: Independence from c-src or c-yes activation

Annals of Surgical Oncology

Volumn 4, Issue 3, 1997, Pages 264-268

  Han, Noel M ^a,b   Declan Fleming, R Y ^a,b   Curley, Steven A ^a   Gallick, Gary E ^b,c  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Colon cancer; Focal adhesion kinase; Liver metastasis; Tumor progression

Indexed keywords

CELL ADHESION MOLECULE; FOCAL ADHESION KINASE; FOCAL ADHESION KINASE 1; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, HUMAN; TUMOR MARKER;

ARTICLE; CARCINOMA; COLORECTAL TUMOR; ENZYMOLOGY; HUMAN; LIVER TUMOR; METABOLISM; METASTASIS; PATHOLOGY; PROGNOSIS; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY; SURVIVAL;

CARCINOMA; CELL ADHESION MOLECULES; COLORECTAL NEOPLASMS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; LIVER NEOPLASMS; PROGNOSIS; PROTEIN-TYROSINE KINASES; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY; SRC-FAMILY KINASES; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0031112814     PISSN: 10689265     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02306620     Document Type: Article

References (18)

1. Nicolson GL. Cancer metastasis: tumor cell and host organ properties important in metastasis to specific secondary sites. Biochem Biophys Acta 1988;948:175.
2. Poste G. Pathogenesis of metastatic disease: implications for current therapy and for the development of new therapeutic strategies. Cancer Treat Rep 1986;70:183-199.
3. Ilic D, Furuta Y, Kanazawa S, et al. Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature 1995;377:539-44.
4. c-src in progressive stages of human colorectal cancer. J Clin Invest 1993;91:53-60.
5. Zetter BR. Adhesion molecules in tumor metastasis. Semin Cancer Biol 1993;4:219-29.
6. Resales C, O'Brien V, Kornberg L, Juliano R. Signal transduction by cell adhesion receptors. Biochim Biophys Acta 1995;1242:77-98.
7. Richardson A, Parsons JT. Signal transduction through integrins: a central role for focal adhesion kinase. Bioessays 1994;17:229-36.
8. Meredith JEJ, Fazeli B, Schwartz MA. The extracellular matrix as a cell survival factor. Mol Biol Cell 1993;4:953-61.
9. Guan JL, Shalloway D. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Nature 1992;358:90-92.
10. FAK) in invasive human tumors. Cancer Res 1995;55:2752-5.
11. Calalb MB, Polte TR, Hanks SK. Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases. Mol Cell Biol 1995;15:954-63.
12. Weiner TM, Liu ET, Craven RJ, Cance WG. Expression of focal adhesion kinase gene and invasive cancer. Lancet 1993;342:1024-5.
13. Owens LV, Xu L, Dent GA, et al. Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer. Ann Surg Oncol 1996;3:100-105.
14. src. Mol Cell Biol 1994;14:1680-8.
15. Zhao Y, Krueger JG, Sudol M. Expression of cellular-yes protein in mammalian tissues. Oncogene 1990;5:1629-35.
16. Cartwright CA, Coad CA, Egbert BM. Elevated c-src tyrosine kinase activity in premalignant epithelia of ulcerative colitis. J Clin Invest 1994;93:509-15.
17. Park J, Meisler AI, Cartwright CA. c-yes tyrosine kinase activity in human colon carcinoma. Oncogene 1993;8:2627-35.
18. c-yes in human carcinoma liver metastases. Clin Cancer Res 1996;2:1397-1404.