4D-QSAR analysis of a set of propofol analogues: Mapping binding sites for an anesthetic phenol on the GABAA receptor

Journal of Medicinal Chemistry

Volumn 45, Issue 15, 2002, Pages 3210-3221

  Krasowski, Matthew D ^a   Hong, Xuan ^b   Hopfinger, A J ^b   Harrison, Neil L ^c  

^a UNIVERSITY OF CHICAGO MEDICAL CENTER   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYCLOPENTYLPHENOL; 2 HYDROXY 3 ISOPROPYLBENZOIC ACID; 2 ISOPROPYLPHENOL; 2 ISOPROPYLTHIOPHENOL; 2 TERT BUTYL 6 METHYLPHENOL; 2,4 DI SEC BUTYLPHENOL; 2,4 DI(TERT BUTYL)PHENOL; 2,6 DI SEC BUTYLPHENOL; 2,6 DI TERT BUTYLPHENOL; 2,6 DIBROMOPHENOL; 2,6 DIETHYLPHENOL; 2,6 DIETHYLPHENYL BROMIDE; 2,6 DIETHYLPHENYL ISOTHIOCYANATE; 2,6 DIISOPROPYLCATECHOL; 2,6 DIISOPROPYLPHENYL ISOCYANATE; 2,6 DIISOPROPYLPHENYL ISOTHIOCYANATE; 2,6 DIMETHYLTHIOPHENOL; 2,6 XYLENOL; 3,5 DI TERT BUTYLPHENOL; 3,5 DIISOPROPYLCATECHOL; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 IODO 2,6 DIISOPROPYLPHENOL; ANESTHETIC AGENT; DIISOPROPYLBENZENE; PHENOL DERIVATIVE; PROPOFOL; PROPOFOL DERIVATIVE; SYRINGOL; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AGONIST; ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG RECEPTOR BINDING; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR INTERACTION; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR UPREGULATION; RIGHTING REFLEX; TADPOLE;

ALGORITHMS; ANESTHETICS, GENERAL; ANIMALS; BINDING SITES; EXCITATORY AMINO ACID AGONISTS; HUMANS; HYDROPHOBICITY; LARVA; LIGANDS; MODELS, MOLECULAR; PROPOFOL; PROTEIN SUBUNITS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0037130185     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010461a     Document Type: Article

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