A Single M1 Residue in the β2 Subunit Alters Channel Gating of GABAA Receptor in Anesthetic Modulation and Direct Activation

Journal of Biological Chemistry

Volumn 278, Issue 44, 2003, Pages 42821-42828

  Chang, Chang Sheng S ^a   Olcese, Riccardo ^a   Olsen, Richard W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETICS; BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION;

ANESTHETIC MODULATION;

BIOCHEMISTRY;

4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ANESTHETIC AGENT; ARGININE; ASPARTIC ACID; CYSTEINE; ETOMIDATE; GLYCINE; ISOLEUCINE; PENTOBARBITAL; PHENYLALANINE; PROPOFOL; RECEPTOR SUBUNIT; SERINE; THYRONINE; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION;

ADJUVANTS, ANESTHESIA; ALLOSTERIC SITE; AMINO ACID SEQUENCE; ANESTHETICS; ANESTHETICS, INTRAVENOUS; ANIMALS; CLONING, MOLECULAR; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETOMIDATE; KINETICS; LIGANDS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PENTOBARBITAL; POINT MUTATION; PREGNANEDIONES; PROPOFOL; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; RNA, MESSENGER; XENOPUS;

ANIMALIA;

EID: 0242353360     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M306978200     Document Type: Article

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