Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: A new mechanism of insulin resistance in humans

Diabetologia

Volumn 52, Issue 10, 2009, Pages 2169-2181

  Monroy, A ^a   Kamath, S ^a   Chavez, A O ^a   Centonze, V E ^a   Veerasamy, M ^a   Barrentine, A ^a   Wewer, J J ^a   Coletta, D K ^a   Jenkinson, C ^a   Jhingan, R M ^a   Smokler, D ^b   Reyna, S ^a   Musi, N ^a   Khokka, R ^b   Federici, M ^c   Tripathy, D ^a   Defronzo, R A ^a   Folli, F ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Human type 2 diabetes mellitus; Insulin resistance; TACE; TIMP3

Indexed keywords

CHLOROTRIANISENE; DIPEPTIDYL CARBOXYPEPTIDASE; GLUCOSE; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6 RECEPTOR; LEPTIN; MESSENGER RNA; PALMITIC ACID; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 1; TUMOR NECROSIS FACTOR ALPHA RECEPTOR 2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; WESTERN BLOTTING;

ADAM PROTEINS; ADULT; BLOTTING, WESTERN; DIABETES MELLITUS, TYPE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN RESISTANCE; MALE; MUSCLE, SKELETAL; RECEPTORS, INTERLEUKIN-6; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 69949130225     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1451-3     Document Type: Article

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