Acetylsalicylic acid improves lipid-induced insulin resistance in healthy men

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 3, 2006, Pages 964-967

  Möhlig, Matthias ^a   Freudenberg, Madlen ^b   Bobbert, Thomas ^b   Ristow, Michael ^b   Rochlitz, Helmut ^b   Weickert, Martin O ^b   Pfeiffer, Andreas F H ^b   Spranger, Joachim ^b  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ADIPONECTIN; C REACTIVE PROTEIN; INSULIN; INTERLEUKIN 6; LIPID;

ADIPOCYTE; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; GLUCOSE INFUSION; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INFLAMMATION; INSULIN RESISTANCE; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; PRIORITY JOURNAL;

ADIPONECTIN; ASPIRIN; BLOOD GLUCOSE; C-REACTIVE PROTEIN; FATTY ACIDS, NONESTERIFIED; GLUCOSE CLAMP TECHNIQUE; HUMANS; HYPERINSULINISM; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; REFERENCE VALUES;

RODENTIA;

EID: 33644820179     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1889     Document Type: Article

References (19)

1. Boden G, Lebed B, Schatz M, Homko C, Lemieux S 2001 Effects of acute changes of plasma free fatty acids on intramyocellular fat content and insulin resistance in healthy subjects. Diabetes 50:1612-1617
2. Itani SI, Ruderman NB, Schmieder F, Boden G 2002 Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IκB-α. Diabetes 51:2005-2011
3. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293:1673-1677
4. Röhl M, Pasparakis M, Baudler S, Baumgartl J, Gautam D, Huth M, De Lorenzi R, Krone W, Rajewsky K, Brüning JC 2004 Conditional disruption of IκB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest 113:474-481
5. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI 2001 Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108:437-446
6. Bobbert T, Rochlitz H, Wegewitz U, Akpulat S, Mai K, Weickert MO, Mohlig M, Pfeiffer AF, Spranger J 2005 Changes of adiponectin oligomer composition by moderate weight reduction. Diabetes 54:2712-2719
7. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y 2000 Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway. Circulation 102:1296-1301
8. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, Kihara S, Funahashi T, Tenner AJ, Tomiyama Y, Matsuzawa Y 2000 Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96:1723-1732
9. Gudmundsson A, Ershler WB, Goodman B, Lent SJ, Barczi S, Carnes M 1997 Serum concentrations of interleukin-6 are increased when sampled through an indwelling venous catheter. Clin Chem 43:2199-2201
10. Boden G 2001 Free fatty acids-the link between obesity and insulin resistance. Endocr Pract 7:44-51
11. Festa A, D'Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM 2000 Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102:42-47
12. Bastard JP, Maachi M, Van Nhieu JT, Jardel C, Bruckert E, Grimaldi A, Robert JJ, Capeau J, Hainque B 2002 Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J Clin Endocrinol Metab 87:2084-2089
13. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC, Matsuzawa Y 2001 Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50:1126-1133
14. Jiang G, Dallas-Yang Q, Liu F, Moller DE, Zhang BB 2003 Salicylic acid reverses phorbol 12-myristate-13-acetate (PMA)- and tumor necrosis factor α (TNFα)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance in human embryonic kidney 293 (HEK293) cells. J Biol Chem 278:180-186
15. Gao Z, Zuberi A, Quon MJ, Dong Z, Ye J 2003 Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J Biol Chem 278:24944-24950
16. Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI 2002 Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. J Clin Invest 109:1321-1326
17. Giugliano D, Sacca L, Scognamiglio G, Ungaro B, Torella R 1982 Influence of acetylsalicylic acid on glucose turnover in normal man. Diabet Metab 8:279-282
18. Bratusch-Marrain PR, Vierhapper H, Komjati M, Waldhausl WK 1985 Acetyl-salicylic acid impairs insulin-mediated glucose utilization and reduces insulin clearance in healthy and non-insulin-dependent diabetic men. Diabetologia 28:671-676
19. Newman WP, Brodows RG 1983 Aspirin causes tissue insensitivity to insulin in normal man. J Clin Endocrinol Metab 57:1102-1106