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Volumn 125, Issue 34, 2003, Pages 10184-10185

Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution

Author keywords

[No Author keywords available]

Indexed keywords

ZINC COMPLEX;

EID: 0041429638     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036317r     Document Type: Article
Times cited : (110)

References (26)
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    • Metal-ion-induced conformational stabilization of α-helix peptide or protein: (a) Cline, D. J.; Thorpe, C.; Schneider, J. P. J. Am. Chem. Soc. 2003, 125, 2923. (b) Mito-oka, Y.; Tsukiji, S.; Hiraoka, T.; Kasagi, N.; Shinkai, S.; Hamachi, I. Tetrahedon Lett. 2001, 42, 7059. (c) Hamachi, I.; Kasagi, N.; Nagase, T.; Kiyonaka, S.; Mito-oka, Y.; Shinkai, S. Chem. Lett. 2001, 16. (d) Hamachi, I.; Eboshi, R.; Watanabe, J.; Shinkai, S. J. Am. Chem. Soc. 2000, 122, 4529, (e) Hamachi, I.; Yamada, Y.; Matsugi, T.; Shinkai, S. Chem. Eur. J. 1999, 5, 1503. (f) Ghadiri, M. R.; Fernholz, A. K. J. Am. Chem. Soc. 1990, 112, 9633. (g) Ghadiri, M. R.; Choi, C. J. Am. Chem. Soc. 1990, 112, 1630. (h) Ruan, F.; Chen, Y.; Hopkins, P. B. J. Am. Chem. Soc. 1990, 112, 9403.
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  • 19
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    • note
    • Synthesis and characterization of these receptors were conducted according to the method described in the Supporting Information.
  • 21
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    • note
    • In 6,6′-Zn(Dpa)-Bpy, the nitrogens of the bipyridyl ring are involved in the chelation to zinc(II), and as a result, there is not any labile site for peptide binding in the zinc complex.
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    • Hubbard, S. R. EMBO J. 1997, 16, 5573. X-ray crystallographic structural analysis of IRK indicated that the distance between pY1158 and pY1162 is approximately 18 Å.
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  • 26
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    • note
    • The tilted conformational change induced by peptide binding may be coincident with the decrease of the fluorescence intensity of 5,5′-Zn(Dpa)-Bpy.


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