The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2, 5-dione) spontaneously forms conjugates with common components of cell culture medium

Drug Metabolism and Disposition

Volumn 35, Issue 7, 2007, Pages 1017-1022

  Wilsher, Nicola ^a   Court, Will J ^a   Ruddle, Ruth ^a   Newbatt, Yvette M ^a   Aherne, Wynne ^a   Sheldrake, Peter W ^a   Jones, Neil P ^a   Katan, Matilda ^a   Eccles, Suzanne A ^a   Raynaud, Florence I ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 2,5 PYRROLIDINEDIONE; AMINE; BOVINE SERUM ALBUMIN; GLUTAMINE; GLUTATHIONE; MALEIMIDE; PHOSPHATE BUFFERED SALINE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C INHIBITOR; THIOL;

ARTICLE; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL ASSAY; CHEMICAL REACTION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CONJUGATION; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG PROTEIN BINDING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; SUPPLEMENTATION;

ARTIFACTS; BIOLOGICAL ASSAY; CALCIUM SIGNALING; CELL LINE, TUMOR; CULTURE MEDIA; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; ESTRENES; GLUTAMINE; GLUTATHIONE; HALF-LIFE; HUMANS; PHOSPHOLIPASE C; PROTEIN BINDING; PYRROLIDINONES; SERUM ALBUMIN, BOVINE; TIME FACTORS;

BOVINAE;

EID: 34250746387     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.014498     Document Type: Article

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