Genetic variants of TCF7L2 are associated with insulin resistance and related metabolic phenotypes in Taiwanese adolescents and Caucasian young adults

Journal of Clinical Endocrinology and Metabolism

Volumn 94, Issue 9, 2009, Pages 3575-3582

  Liu, Pi Hua ^a   Chang, Yi Cheng ^b   Jiang, Yi Der ^b   Chen, Wei J ^a   Chang, Tien Jyun ^b   Kuo, Shan Shan ^b   Lee, Kuan Ching ^b   Hsiao, Po Chang ^a   Chiu, Ken C ^c,d   Chuang, Lee Ming ^b,e  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; TRANSCRIPTION FACTOR 7 LIKE 2; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; ARTICLE; CAUCASIAN; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GLUCOSE HOMEOSTASIS; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; SYSTOLIC BLOOD PRESSURE; TAIWAN;

EID: 69949111930     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-0609     Document Type: Article

References (41)

1. Florez JC, Jablonski KA, Bayley N, Pollin TI, de Bakker PI, Shuldiner AR, Knowler WC, Nathan DM, Altshuler D 2006 TCF7L2 polymorphismsandprogression to diabetes in the Diabetes Prevention Program. N Engl J Med 355:241-250 (Pubitemid 44079339)
2. Grant SF, Thorleifsson G, Reynisdottir I, Benediktsson R, Manolescu A, Sainz J, Helgason A, Stefansson H, Emilsson V, Helgadottir A, Styrkarsdottir U, Magnusson KP, Walters GB, Palsdottir E, Jonsdottir T, Gudmundsdottir T, Gylfason A, Saemundsdottir J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Gudnason V, Sigurdsson G, Thorsteinsdottir U, Gulcher JR, Kong A, Stefansson K 2006 Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323 (Pubitemid 43315754)
3. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjö gren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163
4. Munoz J, Lok KH, Gower BA, Fernandez JR, Hunter GR, Lara- Castro C, De Luca M, Garvey WT 2006 Polymorphism in the transcription factor 7-like 2 (TCF7L2) gene is associated with reduced insulin secretion in nondiabetic women. Diabetes 55:3630-3634 (Pubitemid 44923627)
5. Saxena R, Gianniny L, Burtt NP, Lyssenko V, Giuducci C, Sjögren M, Florez JC, Almgren P, Isomaa B, Orho-Melander M, Lindblad U, Daly MJ, Tuomi T, Hirschhorn JN, Ardlie KG, Groop LC, Altshuler D 2006 Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals. Diabetes 55:2890-2895 (Pubitemid 44923692)
6. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, Duren WL, Erdos MR, Stringham HM, Chines PS, Jackson AU, Prokunina- Olsson L, Ding CJ, Swift AJ, Narisu N, Hu T, Pruim R, Xiao R, Li XY, Conneely KN, Riebow NL, Sprau AG, Tong M, White PP, Hetrick KN, Barnhart MW, Bark CW, Goldstein JL, Watkins L, Xiang F, Saramies J, Buchanan TA, Watanabe RM, Valle TT, Kinnunen L, Abecasis GR, Pugh EW, Doheny KF, Bergman RN, Tuomilehto J, Collins FS, Boehnke M 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341-1345 (Pubitemid 46871655)
7. Wang J, Kuusisto J, Vänttinen M, Kuulasmaa T, Lindström J, Tuomilehto J, Uusitupa M, Laakso M 2007 Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50:1192-1200 (Pubitemid 46701561)
8. Prestwich TC, Macdougald OA 2007 Wnt/β-catenin signaling in adipogenesis and metabolism. Curr Opin Cell Biol 19:612-617
9. Liu Z, Habener JF 2008 Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic β-cell proliferation. J Biol Chem 283:8723-8735
10. Shu L, Sauter NS, Schulthess FT, Matveyenko AV, Oberholzer J, Maedler K 2008 Transcription factor 7-like 2 regulates β-cell survival and function in human pancreatic islets. Diabetes 57:645-653
11. Chang YC, Chang TJ, Jiang YD, Kuo SS, Lee KC, Chiu KC, Chuang LM 2007 Association study of the genetic polymorphisms of the transcription factor 7-like 2 (TCF7L2) gene and type 2 diabetes in the Chinese population. Diabetes 56:2631-2637 (Pubitemid 47523272)
12. Tsou PL, Jiang YD, Chang CC, Wei JN, Sung FC, Lin CC, Chiang CC, Tai TY, Chuang LM 2004 Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care 27: 308-313 (Pubitemid 38174049)
13. Kuo SY, Liu PH, Chuang LM, Chen WJ 2006 The Taipei Adolescent Twin/Sibling Family Study II: depression, insulin resistance, and hormonal factors. Twin Res Hum Genet 9:895-898
14. Liu PH, Jiang YD, Chen WJ, Chang CC, Lee TC, Sun HS, Chuang LM 2008 Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: a multivariate twin/ sibling analysis. Twin Res Hum Genet 11:495-504
15. Hansen T, Drivsholm T, Urhammer SA, Palacios RT, Vølund A, Borch-Johnsen K, Pedersen O 2007 The BIGTT test: a novel test for simultaneous measurement of pancreatic β-cell function, insulin sensitivity, and glucose tolerance. Diabetes Care 30:257-262 (Pubitemid 46201651)
16. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 1985 Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419 (Pubitemid 15018832)
17. Seltzer HS, Allen EW, Herron Jr AL, Brennan MT 1967 Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus. J Clin Invest 46:323-335
18. Bergman RN, Phillips LS, Cobelli C 1981 Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and β-cell glucose sensitivity from the response to intravenous glucose. J Clin Invest 68:1456-1467 (Pubitemid 12194400)
19. Chiu KC, Chuang LM, Yoon C 2001 Comparison of measured and estimated indices of insulin sensitivity and β cell function: impact of ethnicity on insulin sensitivity and β cell function in glucose-tolerant and normotensive subjects. J Clin Endocrinol Metab 86:1620-1625 (Pubitemid 32374914)
20. The International Hap Map Consortium 2005 A haplotype map of the human genome. Nature 437:1299-1320
21. Barrett JC, Fry B, Maller J, Daly MJ 2005 Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265 (Pubitemid 40202029)
22. Bell PA, Chaturvedi S, Gelfand CA, Huang CY, Kochersperger M, Kopla R, Modica F, Pohl M, Varde S, Zhao R, Zhao X, Boyce-Jacino MT, Yassen A 2002 SNPstream UHT: ultra-high throughput SNP genotyping for pharmacogenomics and drug discovery. Biotechniques [Erratum (2003) 34:496] Suppl: 70-72, 74, 76-77 (Pubitemid 34615027)
23. Wigginton JE, Abecasis GR 2005 PEDSTATS: descriptive statistics, graphics and quality assessment for gene mapping data. Bioinformatics 21:3445-3447
24. Abecasis GR, Cherny SS, Cookson WO, Cardon LR 2002 Merlin- rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 30:97-101
25. Abecasis GR, Cardon LR, Cookson WO 2000 A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
26. Purcell S, Cherny SS, Sham PC 2003 Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 19:149-150 (Pubitemid 36150192)
27. Miyake K, Horikawa Y, Hara K, Yasuda K, Osawa H, Furuta H, Hirota Y, Yamagata K, Hinokio Y, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Yamamoto K, Tokunaga K, Takeda J, Makino H, Nanjo K, Kadowaki T, Kasuga M2008 Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects. J Hum Genet 53:174-180
28. Ren Q, Han XY, Wang F, Zhang XY, Han LC, Luo YY, Zhou XH, Ji LN 2008 Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. Diabetologia 51:1146-1152
29. Cauchi S, Meyre D, Dina C, Choquet H, Samson C, Gallina S, Balkau B, Charpentier G, Pattou F, Stetsyuk V, Scharfmann R, Staels B, Frühbeck G, Froguel P 2006 Transcription factor TCF7L2 genetic study in the French population: expression in human β-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903-2908 (Pubitemid 44923694)
30. Elbein SC, Chu WS, Das SK, Yao-Borengasser A, Hasstedt SJ, Wang H, Rasouli N, Kern PA 2007 Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia 50:1621-1630 (Pubitemid 47036661)
31. Ross SE, Hemati N, Longo KA, Bennett CN, Lucas PC, Erickson RL, MacDougald OA 2000 Inhibition of adipogenesis by Wnt signaling. Science 289:950-953
32. Wright WS, Longo KA, Dolinsky VW, Gerin I, Kang S, Bennett CN, Chiang SH, Prestwich TC, Gress C, Burant CF, Susulic VS, MacDougald OA 2007 Wnt10b inhibits obesity in ob/ob and agouti mice. Diabetes 56:295-303 (Pubitemid 46263064)
33. Mani A, Radhakrishnan J, Wang H, Mani A, Mani MA, Nelson- Williams C, Carew KS, Mane S, Najmabadi H, Wu D, Lifton RP 2007 LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315:1278-1282 (Pubitemid 46364265)
34. Huertas-Vazquez A, Plaisier C, Weissglas-Volkov D, Sinsheimer J, Canizales-Quinteros S, Cruz-Bautista I, Nikkola E, Herrera- Hernandez M, Davila-Cervantes A, Tusie-Luna T, Taskinen MR, Aguilar-Salinas C, Pajukanta P 2008 TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia. Diabetologia 51:62-69 (Pubitemid 50000014)
35. Cauchi S, Meyre D, Choquet H, Dina C, Born C, Marre M, Balkau B, Froguel P, for the DSG 2006 TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) Study. Diabetes 55:3189-3192 (Pubitemid 44923661)
36. Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, Gunnarsdottir S, Adeyemo A, Chen Y, Chen G, Reynisdottir I, Benediktsson R, Hinney A, Hansen T, Andersen G, Borch-Johnsen K, Jorgensen T, Schäfer H, Faruque M, Doumatey A, Zhou J, Wilensky RL, Reilly MP, Rader DJ, Bagger Y, Christiansen C, Sigurdsson G, Hebebrand J, Pedersen O, Thorsteinsdottir U, Gulcher JR, Kong A, Rotimi C, Stefánsson K 2007 Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39:218-225 (Pubitemid 46184353)
37. Melzer D, Murray A, Hurst AJ, Weedon MN, Bandinelli S, Corsi AM, Ferrucci L, Paolisso G, Guralnik JM, Frayling TM 2006 Effects of the diabetes linked TCF7L2 polymorphism in a representative older population. BMC Med 4:34 (Pubitemid 46189714)
38. Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, t'Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A 2007 Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 50:2443-2450
39. Duval A, Rolland S, Tubacher E, Bui H, Thomas G, Hamelin R 2000 The human T-cell transcription factor-4 gene: structure, extensive characterization of alternative splicings, and mutational analysis in colorectal cancer cell lines. Cancer Res 60:3872-3879 (Pubitemid 32204580)
40. Shiina H, Igawa M, Breault J, Ribeiro-Filho L, Pookot D, Urakami S, Terashima M, Deguchi M, Yamanaka M, Shirai M, Kaneuchi M, Kane CJ, Dahiya R 2003 The human T-cell factor-4 gene splicing isoforms, Wnt signal pathway, and apoptosis in renal cell carcinoma. Clin Cancer Res 9:2121-2132
41. Howng SL, Huang FH, Hwang SL, Lieu AS, Sy WD, Wang C, Hong YR 2004 Differential expression and splicing isoform analysis of human Tcf-4 transcription factor in brain tumors. Int J Oncol 25: 1685-1692