Synthesis of antibacterial pseudopeptides with less hemolytic activity from a cytotoxic peptide and their pH-dependent activity

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 19, 2009, Pages 5627-5631

  Kim, Sung Min ^a   Kim, Joung Min ^a   Cho, Hyeongjin ^a   Lee, Keun Hyeung ^a  

^a Inha University   (South Korea)

Author keywords

Antibacterial peptide; Antibacterial pseudopeptide; Hydrophobicity; Non peptide; Reduced amide bond; Selectivity

Indexed keywords

AMIDE; POLYPEPTIDE ANTIBIOTIC AGENT; PSEUDOPEPTIDE;

ANTIBACTERIAL ACTIVITY; ARTICLE; BINDING AFFINITY; CYTOTOXICITY; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; HEMOLYSIS; HYDROPHOBICITY; NONHUMAN; PH; PKA; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ERYTHROCYTES; HEMOLYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; MICROBIAL SENSITIVITY TESTS; PEPTIDES;

EID: 69949094395     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.08.031     Document Type: Article

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