The key events dose-response framework: A foundation for examining variability in elicitation thresholds for food allergens

Critical Reviews in Food Science and Nutrition

Volumn 49, Issue 8, 2009, Pages 729-739

  Taylor, Steve L ^a   Gendel, Steven M ^b   Houben, Geert F ^c   Julien, Elizabeth ^d  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c TNO   (Netherlands)

^d International Life Sciences Institute   (United States)

Author keywords

Food allergy; Key Events Dose Response Framework; Low dose dose response; Minimal eliciting dose; Thresholds

Indexed keywords

ALLERGEN;

ALGORITHM; ARTICLE; DOSE RESPONSE; FOOD ALLERGY; HUMAN; PUBLIC HEALTH;

ALGORITHMS; ALLERGENS; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FOOD HYPERSENSITIVITY; HUMANS; PUBLIC HEALTH;

EID: 69849091476     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408390903098707     Document Type: Article

References (51)

1. Aalberse, R. C., Akkerdaas, J. H. and Van Ree, R. (2001). Cross-reactivity of IgE antibodies to allergens. Allergy 56:478-490.
2. Ballmer-Weber B. K. (2002). Lipid transfer protein as a panallergen? Allergy 57:873-875.
3. Barnes, R. M. R. (1995). IgG and IgA antibodies to dietary antigens in food allergy and intolerance. Clin. Exp. Allergy 25:7-9.
4. Bernhisel-Broadbenet J. and Sampson, H. A. (1989). Cross-allergenicity in the legume botanical family in children with food hypersensitivity. J Allergy Clin Immunol. 83:435-440.
5. Bindslev-Jensen, C., Briggs, D. and Osterballe, M. (2002). Can we determine a threshold level for allergenic foods by statistical analysis of published data in the literature? Allergy 57:741-746.
6. Bishop, J. M., Hill, D. J. and Hosking, C. S. (1990). Natural history of cow milk allergy: clinical outcome. J. Pediatr. 116:862-867.
7. Bock, S. A. (1986). The natural history of adverse reactions to food. N Engl Reg Allergy Proc. 7:504-510.
8. Celik, G., Pichler, W. J., Adkinson, N. F. Jr. (2009). Drug allergy. In: Middleton's Allergy Principles and Practices, Vol. 2, 7th ed., pp. 1205-1226.
9. Adkinson, N. F. Jr., Holgate, S. T., Bochner, B. S., Lemanske, R. F. Jr, Busse, W. W., and Simons, F. E. R. Eds., Elsevier Health Sciences, New York.
10. Crevel, R. W. R., Briggs, D., Hefle, S. L., Knulst, A. C. and Taylor, S. L. (2007). Hazard characterisation in food allergen risk assessment: the application of statistical approaches and the use of clinical data. Food Chem. Toxicol. 45:691-701.
11. Flicker, S. and Valenta, R. (2003). Renaissance of the blocking antibody concept in type I allergy. Int. Arch. Allergy Immunol. 132:13-24.
12. Gandhi, C. and Wasserman, S. I. (2009). Biochemical Mediators of Allergic Reactions. In: Patterson's Allergic Diseases, 7th Edition. Gram-mer, L., and Greenberger, P. Eds., Lippincott, Williams and Wilkins, Philadelphia.
13. Goodman, R. E., Vieths, S., Sampson, H. A., Hill, D., Ebisawa, M., Taylor, S. L. and van Ree, R. (2008). Allergenicity assessment of genetically modified crops-what makes sense? Nature Biotechnol. 26:73-81.
14. Health Council of the Netherlands (2007). Food Allergy. The Hague: Health Council of the Netherlands, Publication No. 2007/07.
15. Hefle, S., Nordlee, J. and Taylor, S. L. (1996). Allergenic foods. Crit. Rev. Food Sci. Nutr. 36:S91-S118.
16. Hefle, S. L., Furlong, T. J., Niemann, L., Lemon-Mule, H., Sicherer, S. and Taylor, S. L. (2007). Consumer attitudes and risks associated with packaged foods having advisory labeling regarding the presence of peanuts. J. Allergy Clin. Immunol. 120:171-176.
17. Hui, J. Y. and Taylor, S. L. (1985). Inhibition of in vivo histamine metabolism in ratsby foodborne and pharmacologic inhibitors of diamine oxidase, histamine N-methyltransferase, and monoamine oxidase. Toxicol. Appl. Pharmacol, 81:241-249.
18. Jones, S. M., Scurlock, A. M., Pons, L., Kulis, M., Perry, T. T., Steele, P., Kamilaris, J., Henry, K. A. and Burks, A. W. (2009). Double-blind, placebo-controlled (DBPC) trial of oral immunotherapy (OIT) in peanut allergic children. J. Allergy Clin. Immunol. 123:S211.
19. Julien, E., Boobis, A., Olin, S. S. and the ILSI Research Foundation Threshold Working Group (2009). The Key Events Dose-Response framework: A cross-disciplinary, mode-of-action based approach to examining dose-response and thresholds. Crit. Rev. Food Sci. Nutr. 49:682-689.
20. Knight, A. K., Blazquez, A. B., Zhang, S., Mayer, L., Sampson, H. A. and Berin, M. C. (2007). CD4 T cells activated in the mesenteric lymph node mediate gastrointestingal food allergy in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 293:G1234-G1243.
21. Knippels, LM., van Wijk, F. and Penninks, A. H. (2004). Food allergy: what do we learn from animal models? Curr Opinion Allergy Clin. Immunol. 4:205-209.
22. Kruizinga, A. G., Briggs, D., Crevel, R., Knulst, A., van de Bosch, L. and Houben, G. (2008). Probabilistic risk assessment model for allergens in food: sensitivity analysis of the minimum eliciting dose and food consumption. Food Chem. Toxicol. 46:1437-1443.
23. Lack, G. (2008). Epidemiologic risks for food allergy. J. Allergy Clin. Immunol. 121:1331-1336.
24. Lehmann, K., Schweimer, K., Reese, G., Randow, S., Suhr, M., Becker, W. M., Vieths, S. and Rosch, P. (2006). Structure and stability of 2S albumin-type peanut allergens: implications for severity of peanut allergic reactions. Biochem J. 394:463-475.
25. Lehrer, S. B., Ayuso, R. and Reese, G. (2003). Seafood allergy and allergens: a review. Marine Biotechnl. 5:339-348.
26. Luccioli, S., Brody, D. T., Hasan, S., Keane-Myers, A., Prussin, C. and Met-calfe, D. D. (2002). IgE(+), Kit(-), I-A/I-E(-) myeloid cells are the initial source of Il-4 after antigen challenge in a mouse model of allergic pulmonary inflammation. J Allergy Clin. Immunol. 110(1):117-124.
27. Mayer, L. (2003). Mucosal Immunity. Pediatr. 111 (Suppl):1595-1600.
28. Moneret-Vautrin, D. A. and Morisset, M. (2005). Adult food allergy. Curr Allergy Asthma Rpt. 5:80-85.
29. Nelde, A., Teufel, M., Hahn, C., Duschl, A., Sebald, W., Brocker, E. B. and Grunewald, S. M. (2001). The impact of the route and frequency of antigen exposure on the IgE response in allergy. Int. Arch. Allergy Immunol. 124(4):461-469.
30. Nowak-Wegrzyn, A. and Sampson, H. A. (2006). Adverse reactions to foods. Med Clin No Am. 90:97-127.
31. Ortolani, C., Ispano, M., Pastorello, E., Bigi, A. and Ansaloni, R. (1988). The oral allergy syndrome. Ann. Allergy 61:47-52.
32. Sabroe, R. A. and Black, A. K. (1997). Angiotensin-converting enzyme (ACE) inhibitors and angio-edema. Br. J. Dermatol 136:153-158.
33. Sampson, H. A. (2003). Anaphylaxis and emergency treatment. Pediatrics 111 (Suppl): 1601-1608.
34. Saxon, A., Kepley, C. and Zhang, K. (2008). Accentuate the negative, eliminate the positive: engineering allergy therapeutics to block allergic reactivity through negative signaling. J. Allergy Clin. Immunol. 121(2):320-325.
35. Sicherer, S. H., Morrow, E. H. and Sampson, H. A. (2000). Dose-response in double-blind, placebo-controlled oral food challenges in children with atopic dermatitis. J. Allergy Clin. Immunol. 105:582-586.
36. Skripak, J. M., Matsui, E. C., Mudd. K. and Wood, R. A. (2007). The natural history of IgE-mediated cow's milk allergy. J. Allergy Clin. Immunol. 120:1172-1177.
37. Spanjersberg, M. Q. I., Kruizinga, A. G., Rennen, M. A. J. and Houben, G. F. (2007). Risk assessment and food allergy: the probabilistic model applied to allergens. Food Chem. Toxicol. 45:49-54.
38. Strobel, S. and Mowat, A. M. (2006). Oral tolerance and allergic responses to food proteins. Curr. Opinion Allergy Clin. Immunol. 6:207-213.
39. Taylor, S. L. and Hefle, S. L. (2001). Food allergies and other food sensitivities. Food Technol. 55(9):68-83.
40. Taylor, S. L. and Hourihane, J. O'B. (2008). Food allergen thresholds of reactivity. In: Food Allergy-Adverse Reactions to Foods and Food Additives, 4th ed. pp 82-89. Metcalfe, D. D., Sampson, H. A., Simon, R. A. Eds., Blackwell Publishing, Malden MA.
41. Taylor, S. L. and Lehrer, S. B. (1996). Principles and characteristics of food allergens. Crit. Rev. Food Sci. Nutr. 36:S69-S89.
42. Taylor, S. L., Hefle, S. L., Bindslev-Jensen, C., Atkins, F. M., Andre, C., Bruijnzeel-Koomen, C., Burks, A. W., Bush, R. K., Ebisawa, M., Eigen-mann, P. A., Host, A., Hourihane, J. O'B., Isolauri, E., Hill, D. J., Knulst, A., Lack, G., Sampson, H. A., Moneret-Vautrin, D. A., Rance, F., Vadas, P. A., Yunginger, J. W., Zeiger, R. S., Salminen, J. W., Madsen, C. and Abbott, P. (2004). A consensus protocol for the determination of the threshold doses for allergenic foods: how much is too much? Clin. Exp. Allergy 34:689-695.
43. Taylor, S. L., Crevel, R. W. R., Sheffield, D., Kabourek, J. and Baumert, J. (2009). Threshold dose for peanut: a risk assessment based upon results from challenges of peanut-allergic individuals. Food Chem. Toxicol. 47:1198-1204.
44. US FDA/CFSAN Threshold Working Group (2008). Approaches to establish thresholds for major food allergens and for gluten in food. J. Food Prot. 71:1043-1088.
45. Untersmayr, E., Scholl, I., Swoboda, I., Beil, W., Forster-Waldl, E., Walter, F., Riemer, A., Kraml, G., Kinaciyan, T., Spitzauer, S., Boltz-Nitulescu, G., Scheiner, O. and Jensen-Jarolim, E. (2003). Antacid medication inhibits digestion of dietary proteins and causes food allergy: a fish allergy model in Balb/c mice. J Allergy Clin. Immunol. 112:616-623.
46. Vadas, P., Gold, M., Perelman, B., Liss, G. M., Lack, G., Blyth, T., Simons, F. E. R., Simons, K. J., Cass, D. and Yeung, J. (2008). Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N. Engl. J. Med. 358:28-35.
47. Van Ree, R. (2004). Clinical importance of cross-reactivity in food allergy. Curr. Opinion Allergy Clin. Immunol. 4:235-240.
48. Venter, C., Pereira, B., Grundy, J., Clayton, C. B., Arshad, S. H. and Dean, T. (2006). Prevalence of sensitization reported and objectively assessed food hypersensitivity amongst six-year-old children: a population-based study. Pediatr. Allergy Immunol. 17:356-363.
49. Wasserman, S. I. (1980). The mast cell: its diversity of chemical mediators. Int. J. Dermatol. 19:7-17.
50. Weiss, S., Robb, G. P. and Ellis, L. B. (1932). The systemic effects of histamine in man. Arch. Int. Med. 49:360.
51. Zeiger, R. S. and Heller, S. (1995). The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomize study of combined maternal and infant food allergen avoidance. J. Allergy Clin. Immunol. 95:1179-1190.