Genetics of the Lp(a)/apo(a) system in an autochthonous Black African population from the Gabon

European Journal of Human Genetics

Volumn 14, Issue 2, 2006, Pages 190-201

  Schmidt, Konrad ^a   Kraft, Hans Georg ^a   Parson, Walther ^a   Utermann, Gerd ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Africa; Apolipoprotein(a); Family study; Heritability; Lipoprotein(a); Quantitative trait locus

Indexed keywords

APOLIPOPROTEIN A; ISOPROTEIN; LIPOPROTEIN A;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BLOOD SAMPLING; CHILD; CONTROLLED STUDY; CORRELATION ANALYSIS; ETHNOLOGY; FEMALE; GABON; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HERITABILITY; HUMAN; HUMAN EXPERIMENT; MALE; NEGRO; POPULATION GENETICS; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; QUANTITATIVE TRAIT LOCUS; REGRESSION ANALYSIS;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; APOLIPOPROTEINS A; CHILD; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FEMALE; GABON; GENE FREQUENCY; HUMANS; LIPOPROTEIN(A); MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE; REGRESSION ANALYSIS;

EID: 31344473090     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201512     Document Type: Article

References (50)

1. Utermann G: Lipoprotein(a); in Scriver CR (ed): The metabolic and molecular bases of inherited diseases. New York: McGraw-Hill, 2001, pp 2753-2787.
2. Utermann G, Menzel HJ, Kraft HG, Duba HC, Kemmler HG, Seitz C: Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma. J Clin Invest 1987; 80: 458-465.
3. Sandholzer C, Hallman DM, Saha N et al: Effects of the apolipoprotein(a) size polymorphism on the lipoprotein(a) concentration in 7 ethnic groups. Hum Genet 1991; 86: 607-614.
4. Helmhold M, Bigge J, Muche R et al: Contribution of the apo[a] phenotype to plasma Lp[a] concentrations shows considerable ethnic variation. J Lipid Res 1991; 32: 1919-1928.
5. Kraft HG, Lingenhel A, Pang RW et al: Frequency distributions of apolipoprotein(a) kringle IV repeat alleles and their effects on lipoprotein(a) levels in Caucasian, Asian, and African populations: The distribution of null alleles is non-random. Eur J Hum Genet 1996; 4: 74-87.
6. Marcovina SM, Albers JJ, Wijsman E, Zhang Z, Chapman NH, Kennedy H: Differences in Lp[a] concentrations and apo[a] polymorphs between black and white Americans. J Lipid Res 1996; 37: 2569-2585.
7. Bovet P, Rickenbach M, Wietlisbach V et al: Comparison of serum lipoprotein(a) distribution and its correlates among black and white populations. Int J Epidemiol 1994; 23: 20-27.
8. Cobbaert C, Mulder P, Lindemans J, Kesteloot H: Serum LP(a) levels in African aboriginal Pygmies and Bantus, compared with Caucasian and Asian population samples. J Clin Epidemiol 1997; 50: 1045-1053.
9. Dube N, Voorbij R, Leus F, Gomo ZA: Lipoprotein(a) concentrations and apolipoprotein(a) isoform distribution in a Zimbabwean population. Cent Afr J Med 2002; 48: 83-87.
10. Kraft HG, Kochl S, Menzel HJ, Sandholzer C, Utermann G: The apolipoprotein (a) gene: A transcribed hypervariable locus controlling plasma lipoprotein (a) concentration. Hum Genet 1992; 90: 220-230.
11. Austin MA, Sandholzer C, Selby JV, Newman B, Krauss RM, Utermann G: Lipoprotein(a) in women twins: Heritability and relationship to apolipoprotein(a) phenotypes. Am J Hum Genet 1992; 51: 829-840.
12. Hong Y, Dahlen GH, Pedersen N, Heller DA, McClearn GE, de Faire U: Potential environmental effects on adult lipoprotein(a) levels: Results from Swedish twins. Atherosclerosis 1995; 117: 295-304.
13. Scholz M, Kraft HG, Lingenhel A et al: Genetic control of lipoprotein(a) concentrations is different in Africans and Caucasians. Eur J Hum Genet 1999; 7: 169-178.
14. Abney M, McPeek MS, Ober C: Broad and narrow heritabilities of quantitative traits in a founder population. Am J Hum Genet 2001; 68: 1302-1307.
15. Mooser V, Scheer D, Marcovina SM et al: The Apo(a) gene is the major determinant of variation in plasma Lp(a) levels in African Americans. Am J Hum Genet 1997; 61: 402-417.
16. Boerwinkle E, Leffert CC, Lin J, Lackner C, Chiesa G, Hobbs HH: Apolipoprotein(a) gene accounts for greater than 90% of the variation in plasma lipoprotein(a) concentrations. J Clin Invest 1992; 90: 52-60.
17. DeMeester CA, Bu X, Gray RJ, Lusis AJ, Rotter JI: Genetic variation in lipoprotein (a) levels in families enriched for coronary artery disease is determined almost entirely by the apolipoprotein (a) gene locus. Am J Hum Genet 1995; 56: 287-293.
18. Perombelon YF, Soutar AK, Knight BL: Variation in lipoprotein(a) concentration associated with different apolipoprotein(a) alleles. J Clin Invest 1994; 93: 1481-1492.
19. Ali S, Bunker CH, Aston CE, Ukoli FA, Kamboh MI: Apolipoprotein A kringle 4 polymorphism and serum lipoprotein (a) concentrations in African blacks. Hum Biol 1998; 70: 477-490.
20. Marcovina SM, Albers JJ, Jacobs Jr DR et al: Lipoprotein[a] concentrations and apolipoprotein[a] phenotypes in Caucasians and African Americans. The CARDIA study. Arterioscler Thromb 1993; 13: 1037-1045.
21. Ogorelkova M, Gruber A, Utermann G: Molecular basis of congenital lp(a) deficiency: A frequent apo(a) 'null' mutation in caucasians. Hum Mol Genet 1999; 8: 2087-2096.
22. Zysow BR, Lindahl GE, Wade DP, Knight BL, Lawn RM: C/T polymorphism in the 5′ untranslated region of the apolipoprotein(a) gene introduces an upstream ATG and reduces in vitro translation. Arterioscler Thromb Vasc Biol 1995; 15: 58-64.
23. Rotimi CN, Cooper RS, Marcovina SM, McGee D, Owoaje E, Ladipo M: Serum distribution of lipoprotein(a) in African Americans and Nigerians: potential evidence for a genotype-environmental effect. Genet Epidemiol 1997; 14: 157-168.
24. Parra EJ, Marcini A, Akey J et al: Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet 1998; 63: 1839-1851.
25. Chakraborty R, Kamboh MI, Nwankwo M, Ferrell RE: Caucasian genes in American blacks: New data. Am J Hum Genet 1992; 50: 145-155.
26. Raponda-Walker A, Sillans R: Rites et croyances des peuples du Gabon. Paris: Présence Africaine, 1995.
27. Rifai N, Heiss G, Doetsch K: Lipoprotein(a) at birth, in blacks and whites. Atherosclerosis 1992; 92: 123-129.
28. Kronenberg F, Lobentanz EM, Konig P, Utermann G, Dieplinger H: Effect of sample storage on the measurement of lipoprotein[a], apolipoproteins B and A-IV, total and high density lipoprotein cholesterol and triglycerides. J Lipid Res 1994; 35: 1318-1328.
29. Menzel HJ, Dieplinger H, Lackner C et al: Abetalipoproteinemia with an ApoB-100-lipoprotein(a) glycoprotein complex in plasma. Indication for an assembly defect. J Biol Chem 1990; 265: 981-986.
30. Geethanjali FS, Luthra K, Lingenhel A et al: Analysis of the apo(a) size polymorphism in Asian Indian populations: Association with Lp(a) concentration and coronary heart disease. Atherosclerosis 2003; 169: 121-130.
31. Mancini FP, Mooser V, Guerra R, Hobbs HH: Sequence microheterogeneity in apolipoprotein(a) gene repeats and the relationship to plasma Lp(a) levels. Hum Mol Genet 1995; 4: 1535-1542.
32. Gaw A, Boerwinkle E, Cohen JC, Hobbs HH: Comparative analysis of the apo(a) gene, apo(a) glycoprotein, and plasma concentrations of Lp(a) in three ethnic groups. Evidence for no common 'null' allele at the apo(a) locus. J Clin Invest 1994; 93: 2526-2534.
33. Marcovina SM, Albers JJ, Scanu AM et al: Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a). Clin Chem 2000; 46: 1956-1967.
34. Lingenhel A, Kraft HG, Kotze M et al: Concentrations of the atherogenic Lp(a) are elevated in FH. Eur J Hum Genet 1998; 6: 50-60.
35. Trommsdorff M, Kochl S, Lingenhel A et al: A pentanucleotide repeat polymorphism in the 5′ control region of the apolipoprotein(a) gene is associated with lipoprotein(a) plasma concentrations in Caucasians. J Clin Invest 1995; 96: 150-157.
36. Kraft HG, Windegger M, Menzel HJ, Utermann G: Significant impact of the +93 C/T polymorphism in the apolipoprotein(a) gene on Lp(a) concentrations in Africans but not in Caucasians: Confounding effect of linkage disequilibrium. Hum Mol Genet 1998; 7: 257-264.
37. Kraft HG, Haibach C, Lingenhel A et al: Sequence polymorphism in kringle IV 37 in linkage disequilibrium with the apolipoprotein (a) size polymorphism. Hum Genet 1995; 95: 275-282.
38. Kronenberg F, Kuen E, Ritz E et al: Lipoprotein(a) serum concentrations and apolipoprotein(a) phenotypes in mild and moderate renal failure. J Am Soc Nephrol 2000; 11: 105-115.
39. Mooser V, Mancini FP, Bopp S et al: Sequence polymorphisms in the apo(a) gene associated with specific levels of Lp(a) in plasma. Hum Mol Genet 1995; 4: 173-181.
40. Steinlechner M, Schmidt K, Kraft HG, Utermann G, Parson W: Gabon black population data on the ten short tandem repeat loci D3S1358, VWA, D16S539, D2S1338, D8S1179, D21S11, D18S51, D19S433, TH01 and FGA. Int J Legal Med 2002; 116: 176-178.
41. Falconer DS: Introduction to quantitative genetics. Englewood Cliffs, NJ: Prentice Hall, 1996.
42. Haseman JK, Elston RC: The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 1972; 2: 3-19.
43. Sachs L: Statistische Auswertungsmethoden. Berlin: Springer, 1969, pp 417-418.
44. Amos CI, Zhu DK, Boerwinkle E: Assessing genetic linkage and association with robust components of variance approaches. Ann Hum Genet 1996; 60 (Part 2): 143-160.
45. Marcovina SM, Kennedy H, Bittolo BG et al: Fish intake, independent of apo(a) size, accounts for lower plasma lipoprotein(a) levels in Bantu fishermen of Tanzania: The Lugalawa Study. Arterioscler Thromb Vasc Biol 1999; 19: 1250-1256.
46. Ober C, Abney M, McPeek MS: The genetic dissection of complex traits in a founder population. Am J Hum Genet 2001; 69: 1068-1079.
47. Broeckel U, Hengstenberg C, Mayer B et al: A comprehensive linkage analysis for myocardial infarction and its related risk factors. Nat Genet 2002; 30: 210-214.
48. Wildling E, Winkler S, Kremsner PG, Brandts C, Jenne L, Wernsdorfer WH: Malaria epidemiology in the province of Moyen Ogoov, Gabon. Trop Med Parasitol 1995; 46: 77-82.
49. Toure FS, Egwang TG, Millet P, Bain O, Georges AJ, Wahl G: IgG4 serology of loiasis in three villages in an endemic area of south-eastern Gabon. Trop Med Int Health 1998; 3: 313-317.
50. Richard-Lenoble D, Kombila M, Carme B, Gilles JC, Delattre PY: Prevalence of human filariasis with microfilaremia in Gabon. Bull Soc Pathol Exot Filiales 1980; 73: 192-199.