Chitotriosidase levels in healthy elderly subjects

Annals of the New York Academy of Sciences

Volumn 1100, Issue , 2007, Pages 185-188

  Kurt, Ismail ^a   Abasli, Dilek ^a   Cihan, Murat ^a   Serdar, Muhittin A ^a   Olgun, Abdullah ^a   Saruhan, Ercan ^a   Erbil, M Kemal ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Activated tissue macrophages; CHIT; Chitinases; Chitotriosidase

Indexed keywords

BIOLOGICAL MARKER; CHITOTRIOSIDASE; BETA N ACETYLHEXOSAMINIDASE; LIPID;

ADULT; AGED; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME CHEMISTRY; ENZYME SUBSTRATE; FEMALE; FLUOROMETRY; GERIATRIC ASSESSMENT; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; AGE; AGING; ARTICLE; ATHEROSCLEROSIS; BLOOD; CHEMISTRY; GAUCHER DISEASE; GENETICS; HOMOZYGOTE; LYSOSOME; MACROPHAGE; METABOLISM;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; ATHEROSCLEROSIS; GAUCHER DISEASE; HEXOSAMINIDASES; HOMOZYGOTE; HUMANS; LIPIDS; LYSOSOMES; MACROPHAGES;

EID: 34249668229     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1395.017     Document Type: Conference Paper

References (15)

1. BOOT, R.G., H. RENKEMA, A. STRIJLAND, et al. 1995. Cloning of a cDNA encoding chitotriosidase, a human chitinase produced by macrophages. J. Biol. Chem. 270: 26252-26256.
2. BOOT, R.G., T.A. VAN ACHTERBERG, B.E. VAN AKEN, et al. 1999. Strong induction of members of the chitinase family of proteins in atherosclerosis: chitotriosidase and human cartilage gp-39 expressed in lesion macrophages. Arterioscler. Thromb. Vasc. Biol. 19: 687-694.
3. VAN EIJK, M., C.P. VAN ROOMEN, G.H. RENKEMA, et al. 2005. Characterization of human phagocyte-derived chitotriosidase, a component of innate immunity. Int. Immunol. 17: 1505-1512.
4. AERTS, J.M., C. HOLLAK, R. BOOT & A. GROENER. 2003. Biochemistry of glycosphingolipid storage disorders: implications for therapeutic intervention. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 385: 905.
5. BARONE, R., F. Dİ GREORİO, M.A. ROMEO, et al. 1999. Plasma chitotriosidase activity in patients with beta-thalassemia. Blood Cell Mol. Dis. 25: 1-8.
6. BOOT, R.G., G.H. RENKEMA, M. VERHOEK, et al. 1998. The human chitotriosidase gene: nature of inherited enzyme deficiency. J. Biol. Chem. 273: 25680-25685.
7. HOLLAK, C.E., S. VANWEELY, M.H.J. VAN OERS & J.M.F.G. AERTS. 1994. Marked elevation of plasma chitotriosidase activity. A novel hallmark of Gaucher disease. J. Clin. Invest. 93: 1288-1292.
8. HOLLAK, C.E.M., M. MAAS & J.M. AERTS. 2001. Clinically relevant therapeutic endpoints in type I Gaucher disease. J. Inherit. Metab. Dis. 24: 97-105.
9. BRİNKMAN, J., F.A. WİJBURG, C.E. HOLLAK, et al. 2005. Plasma chitotriosidase and CCL18: early biochemical surrogate markers in type B Niemann-Pick disease. J. Inherit. Metab. Dis. 28: 13-20.
10. VEDDER, A.C., J. COX-BRİNKMAN, C.E.M. HOLLAK, et al. 2006. Plasma chitotriosidase in male Fabry patients: a marker for monitoring lipid-laden macrophages and their correction by enzyme replacement therapy. Mol. Genet. Metab. 89: 239-244.
11. GUO, Y., W. HE, A.M. BOER, et al. 1995. Elevated plasma chitotriosidase activity in various lysosomal storage disorders. J. Inheru. Metab. Dis. 18: 717-722.
12. MICHELAKAKIS, H., E. DIMITRIOU & I. LABADARIDIS. 2004. The expanding spectrum of disorders with elevated plasma chitotriosidase activity: an update. J. Inherit. Metab. Dis. 27: 705-706.
13. MICHELIN, K., A. WAJNER, F. DE SOUZA, et al. 2005. Application of a comprehensive protocol for the identification of Gaucher disease in Brazil. Am. J. Med. Genet. 136A: 58-62.
14. GIRALDO, P., A. CENARRO, P. ALFONSO, et al. 2001. Chitotriosidase genotype and plasma activity in patients with type I Gaucher's disease and their relatives (carriers and noncarriers). Haematologica 86: 977-984.
15. ARTIEDA, M., A. CENARRO, A. GAGAN, et al. 2003. Serum chitotriosidase activity is increased in subjects with atherosclerosis disease. Arterioscler. Thromb. Vasc. Biol. 23: 1645.