Chitin checking - Novel insights into asthma

New England Journal of Medicine

Volumn 351, Issue 14, 2004, Pages 1455-1457

  Wills Karp, Marsha ^a   Karp, Christopher L ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; CHITIN; CHITINASE; CYTOKINE; IMMUNOGLOBULIN E; CHIA PROTEIN, HUMAN; INTERLEUKIN 13;

ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL POLARITY; CYTOKINE PRODUCTION; DRUG TARGETING; ENZYME ACTIVITY; IMMUNE RESPONSE; IMMUNOGLOBULIN PRODUCTION; INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL; ANIMAL; ENZYMOLOGY; HUMAN; IMMUNOLOGY; METABOLISM; PATHOPHYSIOLOGY;

ANIMALS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CHITIN; CHITINASE; HUMANS; INTERLEUKIN-13; TH2 CELLS;

EID: 4644286533     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMcibr041294     Document Type: Article

References (5)

1. Zhu Z, Zheng T, Homer RJ, et al. Acidic mammalian chitinase in asthmatic Th2 inflammation and IL-13 pathway activation. Science 2004;304:1678-82.
2. Wills-Karp M, Luyimbazi J, Xu X, et al. Interleukin-13: central mediator of allergic asthma. Science 1998;282:2258-61.
3. Herrera-Estrella A, Chet I. Chitinases in biological control. EXS 1999;87:171-84.
4. Boot RG, Blommaart EF, Swart E, et al. Identification of a novel acidic mammalian chitinase distinct from chitotriosidase. J Biol Chem 2001;276:6770-8.
5. Shibata Y, Foster LA, Bradfield JF, Myrvik QN. Oral administration of chitin down-regulates serum IgE levels and lung eosinophilia in the allergic mouse. J Immunol 2000;164:1314-21.