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Volumn 15, Issue 10, 2009, Pages 1239-1243

Targeting Treg Cells In Situ: Emerging Expansion Strategies for (CD4+CD25+) Regulatory T Cells

Author keywords

CD4+CD25+; Expansion strategies; Immune regulation; In situ manipulation; Marrow allograft resistance; Treg cells

Indexed keywords

ALLOANTIGEN; CYTOKINE ANTIBODY; HLA ANTIGEN CLASS 2; INTERLEUKIN 2;

EID: 69749097294     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2009.06.009     Document Type: Review
Times cited : (13)

References (46)
  • 1
    • 3142519564 scopus 로고    scopus 로고
    • In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures
    • Godfrey W.R., Ge Y.G., Spoden D.J., et al. In vitro-expanded human CD4(+)CD25(+) T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104 (2004) 453-461
    • (2004) Blood , vol.104 , pp. 453-461
    • Godfrey, W.R.1    Ge, Y.G.2    Spoden, D.J.3
  • 2
    • 0035806323 scopus 로고    scopus 로고
    • Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function
    • Levings M.K., Sangregorio R., and Roncarolo M.G. Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med 193 (2001) 1295-1302
    • (2001) J Exp Med , vol.193 , pp. 1295-1302
    • Levings, M.K.1    Sangregorio, R.2    Roncarolo, M.G.3
  • 3
    • 3242801352 scopus 로고    scopus 로고
    • Large-scale in vitro expansion of polyclonal human CD4 + CD25high regulatory T cells
    • Hoffmann P., Eder R., Kunz-Schughart L.A., et al. Large-scale in vitro expansion of polyclonal human CD4 + CD25high regulatory T cells. Blood 104 (2004) 895-903
    • (2004) Blood , vol.104 , pp. 895-903
    • Hoffmann, P.1    Eder, R.2    Kunz-Schughart, L.A.3
  • 4
    • 0037093217 scopus 로고    scopus 로고
    • The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality
    • Taylor P.A., Lees C.J., and Blazar B.R. The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality. Blood 99 (2002) 3493-3499
    • (2002) Blood , vol.99 , pp. 3493-3499
    • Taylor, P.A.1    Lees, C.J.2    Blazar, B.R.3
  • 5
    • 34249805413 scopus 로고    scopus 로고
    • Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4 + T cells, but enrich for antigen-specific Foxp3 + T regulatory cells and promote organ transplant tolerance
    • Turnquist H.R., Raimondi G., Zahorchak A.F., et al. Rapamycin-conditioned dendritic cells are poor stimulators of allogeneic CD4 + T cells, but enrich for antigen-specific Foxp3 + T regulatory cells and promote organ transplant tolerance. J Immunol 178 (2007) 7018-7031
    • (2007) J Immunol , vol.178 , pp. 7018-7031
    • Turnquist, H.R.1    Raimondi, G.2    Zahorchak, A.F.3
  • 6
    • 62749201002 scopus 로고    scopus 로고
    • Expansion of human regulatory T-cells from patients with type 1 diabetes
    • Putnam A.L., Brusko T.M., Lee M.R., et al. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes 58 (2009) 652-662
    • (2009) Diabetes , vol.58 , pp. 652-662
    • Putnam, A.L.1    Brusko, T.M.2    Lee, M.R.3
  • 7
    • 18144396195 scopus 로고    scopus 로고
    • In vitro expanded human CD4 + CD25+ regulatory T cells suppress effector T cell proliferation
    • Earle K.E., Tang Q., Zhou X., et al. In vitro expanded human CD4 + CD25+ regulatory T cells suppress effector T cell proliferation. Clin Immunol 115 (2005) 3-9
    • (2005) Clin Immunol , vol.115 , pp. 3-9
    • Earle, K.E.1    Tang, Q.2    Zhou, X.3
  • 8
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q., Henriksen K.J., Bi M., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 199 (2004) 1455-1465
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3
  • 9
    • 0037026001 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease
    • Cohen J.L., Trenado A., Vasey D., et al. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease. J Exp Med 196 (2002) 401-406
    • (2002) J Exp Med , vol.196 , pp. 401-406
    • Cohen, J.L.1    Trenado, A.2    Vasey, D.3
  • 10
    • 0042512461 scopus 로고    scopus 로고
    • Direct expansion of functional CD25 + CD4+ regulatory T cells by antigen-processing dendritic cells
    • Yamazaki S., Iyoda T., Tarbell K., et al. Direct expansion of functional CD25 + CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med 198 (2003) 235-247
    • (2003) J Exp Med , vol.198 , pp. 235-247
    • Yamazaki, S.1    Iyoda, T.2    Tarbell, K.3
  • 11
    • 38049020656 scopus 로고    scopus 로고
    • Prevention of acute and chronic allograft rejection with CD4 + CD25 + Foxp3+ regulatory T lymphocytes
    • Joffre O., Santolaria T., Calise D., et al. Prevention of acute and chronic allograft rejection with CD4 + CD25 + Foxp3+ regulatory T lymphocytes. Nat Med 14 (2008) 88-92
    • (2008) Nat Med , vol.14 , pp. 88-92
    • Joffre, O.1    Santolaria, T.2    Calise, D.3
  • 12
    • 40449117736 scopus 로고    scopus 로고
    • In vitro expansion improves in vivo regulation by CD4 + CD25+ regulatory T cells
    • Chai J.G., Coe D., Chen D., et al. In vitro expansion improves in vivo regulation by CD4 + CD25+ regulatory T cells. J Immunol 180 (2008) 858-869
    • (2008) J Immunol , vol.180 , pp. 858-869
    • Chai, J.G.1    Coe, D.2    Chen, D.3
  • 13
    • 69749127286 scopus 로고    scopus 로고
    • Functional comparison of freshly isolated and ex-vivo expanded CD4 + CD25 + Foxp3+ regulatory T cells in suppressing murine acute GvHD
    • Sega E.I., Leveson-Gower D., Nguyen V.H., et al. Functional comparison of freshly isolated and ex-vivo expanded CD4 + CD25 + Foxp3+ regulatory T cells in suppressing murine acute GvHD. ASH Annu Meet Abstrs 112 (2008) 812
    • (2008) ASH Annu Meet Abstrs , vol.112 , pp. 812
    • Sega, E.I.1    Leveson-Gower, D.2    Nguyen, V.H.3
  • 14
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., and Rudensky A.Y. Foxp3 programs the development and function of CD4 + CD25+ regulatory T cells. Nat Immunol 4 (2003) 330-336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 15
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan Y.Y., and Flavell R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 445 (2007) 766-770
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 16
    • 33845491455 scopus 로고    scopus 로고
    • Only the CD45RA+ subpopulation of CD4 + CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion
    • Hoffmann P., Eder R., Boeld T.J., et al. Only the CD45RA+ subpopulation of CD4 + CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108 (2006) 4260-4267
    • (2006) Blood , vol.108 , pp. 4260-4267
    • Hoffmann, P.1    Eder, R.2    Boeld, T.J.3
  • 17
    • 65449141433 scopus 로고    scopus 로고
    • Loss of FOXP3 expression in natural human CD4 + CD25+ regulatory T cells upon repetitive in vitro stimulation
    • Hoffmann P., Boeld T.J., Eder R., et al. Loss of FOXP3 expression in natural human CD4 + CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol 39 (2009) 1088-1097
    • (2009) Eur J Immunol , vol.39 , pp. 1088-1097
    • Hoffmann, P.1    Boeld, T.J.2    Eder, R.3
  • 18
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation
    • Kim H.P., and Leonard W.J. CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation. J Exp Med 204 (2007) 1543-1551
    • (2007) J Exp Med , vol.204 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 19
    • 33645759979 scopus 로고    scopus 로고
    • Suppression of natural killer cell-mediated bone marrow cell rejection by CD4 + CD25+ regulatory T cells
    • Barao I., Hanash A.M., Hallett W., et al. Suppression of natural killer cell-mediated bone marrow cell rejection by CD4 + CD25+ regulatory T cells. Proc Natl Acad Sci USA 103 (2006) 5460-5465
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5460-5465
    • Barao, I.1    Hanash, A.M.2    Hallett, W.3
  • 20
    • 28644447974 scopus 로고    scopus 로고
    • Regulatory T cells in ovarian cancer: biology and therapeutic potential
    • Barnett B., Kryczek I., Cheng P., et al. Regulatory T cells in ovarian cancer: biology and therapeutic potential. Am J Reprod Immunol 54 (2005) 369-377
    • (2005) Am J Reprod Immunol , vol.54 , pp. 369-377
    • Barnett, B.1    Kryczek, I.2    Cheng, P.3
  • 21
    • 30144444279 scopus 로고    scopus 로고
    • Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
    • Dannull J., Su Z., Rizzieri D., et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest 115 (2005) 3623-3633
    • (2005) J Clin Invest , vol.115 , pp. 3623-3633
    • Dannull, J.1    Su, Z.2    Rizzieri, D.3
  • 22
    • 34247504608 scopus 로고    scopus 로고
    • Depletion of CD4 + CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro
    • Mahnke K., Schonfeld K., Fondel S., et al. Depletion of CD4 + CD25+ human regulatory T cells in vivo: kinetics of Treg depletion and alterations in immune functions in vivo and in vitro. Int J Cancer 120 (2007) 2723-2733
    • (2007) Int J Cancer , vol.120 , pp. 2723-2733
    • Mahnke, K.1    Schonfeld, K.2    Fondel, S.3
  • 23
    • 36148939150 scopus 로고    scopus 로고
    • IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
    • Litzinger M.T., Fernando R., Curiel T.J., et al. IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity. Blood 110 (2007) 3192-3201
    • (2007) Blood , vol.110 , pp. 3192-3201
    • Litzinger, M.T.1    Fernando, R.2    Curiel, T.J.3
  • 24
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim J.M., Rasmussen J.P., and Rudensky A.Y. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 8 (2007) 191-197
    • (2007) Nat Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 25
    • 0037352740 scopus 로고    scopus 로고
    • Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist
    • Lin C.H., and Hunig T. Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist. Eur J Immunol 33 (2003) 626-638
    • (2003) Eur J Immunol , vol.33 , pp. 626-638
    • Lin, C.H.1    Hunig, T.2
  • 26
    • 58149165361 scopus 로고    scopus 로고
    • Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody
    • Beyersdorf N., Ding X., Blank G., et al. Protection from graft-versus-host disease with a novel B7 binding site-specific mouse anti-mouse CD28 monoclonal antibody. Blood 112 (2008) 4328-4336
    • (2008) Blood , vol.112 , pp. 4328-4336
    • Beyersdorf, N.1    Ding, X.2    Blank, G.3
  • 27
    • 33750339165 scopus 로고    scopus 로고
    • "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3 + CD4 + T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig
    • Lan Y.Y., Wang Z., Raimondi G., et al. "Alternatively activated" dendritic cells preferentially secrete IL-10, expand Foxp3 + CD4 + T cells, and induce long-term organ allograft survival in combination with CTLA4-Ig. J Immunol 177 (2006) 5868-5877
    • (2006) J Immunol , vol.177 , pp. 5868-5877
    • Lan, Y.Y.1    Wang, Z.2    Raimondi, G.3
  • 28
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4 + CD25 + FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., and Roncarolo M.G. Rapamycin selectively expands CD4 + CD25 + FoxP3+ regulatory T cells. Blood 105 (2005) 4743-4748
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3
  • 29
    • 51349165526 scopus 로고    scopus 로고
    • CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4 + T cells in a dose-dependent fashion
    • Kavanagh B., O'Brien S., Lee D., et al. CTLA4 blockade expands FoxP3+ regulatory and activated effector CD4 + T cells in a dose-dependent fashion. Blood 112 (2008) 1175-1183
    • (2008) Blood , vol.112 , pp. 1175-1183
    • Kavanagh, B.1    O'Brien, S.2    Lee, D.3
  • 30
    • 38349137792 scopus 로고    scopus 로고
    • Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function
    • Kessel A., Ammuri H., Peri R., et al. Intravenous immunoglobulin therapy affects T regulatory cells by increasing their suppressive function. J Immunol 179 (2007) 5571-5575
    • (2007) J Immunol , vol.179 , pp. 5571-5575
    • Kessel, A.1    Ammuri, H.2    Peri, R.3
  • 31
    • 38349191376 scopus 로고    scopus 로고
    • Expansion of CD4 + CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis
    • Ephrem A., Chamat S., Miquel C., et al. Expansion of CD4 + CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis. Blood 111 (2008) 715-722
    • (2008) Blood , vol.111 , pp. 715-722
    • Ephrem, A.1    Chamat, S.2    Miquel, C.3
  • 32
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman O., Kovar M., Rubinstein M.P., et al. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 311 (2006) 1924-1927
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3
  • 33
    • 65549091509 scopus 로고    scopus 로고
    • In vivo expansion of T reg cells with IL-2 -mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression
    • Webster K.E., Walters S., Kohler R.E., et al. In vivo expansion of T reg cells with IL-2 -mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 206 (2009) 751-760
    • (2009) J Exp Med , vol.206 , pp. 751-760
    • Webster, K.E.1    Walters, S.2    Kohler, R.E.3
  • 34
    • 67349115219 scopus 로고    scopus 로고
    • In situ activation and expansion of host Tregs: a new approach to enhance donor chimerism and stable engraftment in MHC-matched allogeneic HCT
    • Shatry A., and Levy R.B. In situ activation and expansion of host Tregs: a new approach to enhance donor chimerism and stable engraftment in MHC-matched allogeneic HCT. Biol Blood Marrow Transplant 15 (2009) 785-794
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 785-794
    • Shatry, A.1    Levy, R.B.2
  • 35
    • 60249100179 scopus 로고    scopus 로고
    • Host CD4 + CD25 + T cells can expand and comprise a major component of the Treg compartment after experimental HCT
    • Bayer A.L., Jones M., Chirinos J., et al. Host CD4 + CD25 + T cells can expand and comprise a major component of the Treg compartment after experimental HCT. Blood 113 (2009) 733-743
    • (2009) Blood , vol.113 , pp. 733-743
    • Bayer, A.L.1    Jones, M.2    Chirinos, J.3
  • 36
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • Taylor P.A., Noelle R.J., and Blazar B.R. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 193 (2001) 1311-1317
    • (2001) J Exp Med , vol.193 , pp. 1311-1317
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 37
    • 49049106182 scopus 로고    scopus 로고
    • Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade
    • Verbinnen B., Billiau A.D., Vermeiren J., et al. Contribution of regulatory T cells and effector T cell deletion in tolerance induction by costimulation blockade. J Immunol 181 (2008) 1034-1042
    • (2008) J Immunol , vol.181 , pp. 1034-1042
    • Verbinnen, B.1    Billiau, A.D.2    Vermeiren, J.3
  • 38
    • 58149191877 scopus 로고    scopus 로고
    • Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells
    • Wilson M.S., Pesce J.T., Ramalingam T.R., et al. Suppression of murine allergic airway disease by IL-2:anti-IL-2 monoclonal antibody-induced regulatory T cells. J Immunol 181 (2008) 6942-6954
    • (2008) J Immunol , vol.181 , pp. 6942-6954
    • Wilson, M.S.1    Pesce, J.T.2    Ramalingam, T.R.3
  • 39
    • 33644784733 scopus 로고    scopus 로고
    • IL-2 administration increases CD4 + CD25(hi) Foxp3+ regulatory T cells in cancer patients
    • Ahmadzadeh M., and Rosenberg S.A. IL-2 administration increases CD4 + CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood 107 (2006) 2409-2414
    • (2006) Blood , vol.107 , pp. 2409-2414
    • Ahmadzadeh, M.1    Rosenberg, S.A.2
  • 40
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4 + CD25+ regulatory T cells
    • Zhang H., Chua K.S., Guimond M., et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4 + CD25+ regulatory T cells. Nat Med 11 (2005) 1238-1243
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 41
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Tang Q., Adams J.Y., Penaranda C., et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity 28 (2008) 687-697
    • (2008) Immunity , vol.28 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 42
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4 + CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • Zorn E., Nelson E.A., Mohseni M., et al. IL-2 regulates FOXP3 expression in human CD4 + CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo. Blood 108 (2006) 1571-1579
    • (2006) Blood , vol.108 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3
  • 43
    • 59349091835 scopus 로고    scopus 로고
    • Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation
    • Zorn E., Mohseni M., Kim H., et al. Combined CD4+ donor lymphocyte infusion and low-dose recombinant IL-2 expand FOXP3+ regulatory T cells following allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 15 (2009) 382-388
    • (2009) Biol Blood Marrow Transplant , vol.15 , pp. 382-388
    • Zorn, E.1    Mohseni, M.2    Kim, H.3
  • 44
    • 38849108168 scopus 로고    scopus 로고
    • Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2 and 4-1BB signaling
    • Elpek K.G., Yolcu E.S., Franke D.D., et al. Ex vivo expansion of CD4 + CD25 + FoxP3 + T regulatory cells based on synergy between IL-2 and 4-1BB signaling. J Immunol 179 (2007) 7295-7304
    • (2007) J Immunol , vol.179 , pp. 7295-7304
    • Elpek, K.G.1    Yolcu, E.S.2    Franke, D.D.3
  • 45
    • 66149101300 scopus 로고    scopus 로고
    • Host natural killer T cells induce an IL-4 dependent expansion of donor CD4 + CD25 + Foxp3 + Tregs that protects against graft-versus-host disease
    • Pillai A.B., George T.I., Dutt S., et al. Host natural killer T cells induce an IL-4 dependent expansion of donor CD4 + CD25 + Foxp3 + Tregs that protects against graft-versus-host disease. Blood 113 (2009) 4458-4467
    • (2009) Blood , vol.113 , pp. 4458-4467
    • Pillai, A.B.1    George, T.I.2    Dutt, S.3
  • 46
    • 65949108012 scopus 로고    scopus 로고
    • Seminal fluid drives expansion of the CD4 + CD25 + T regulatory cell pool and induces tolerance to paternal alloantigens in mice
    • Robertson S.A., Guerin L.R., Bromfield J.J., et al. Seminal fluid drives expansion of the CD4 + CD25 + T regulatory cell pool and induces tolerance to paternal alloantigens in mice. Biol Reprod 80 (2009) 1036-1045
    • (2009) Biol Reprod , vol.80 , pp. 1036-1045
    • Robertson, S.A.1    Guerin, L.R.2    Bromfield, J.J.3


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