-
2
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
3
-
-
0035872199
-
Akt/pbotein kinace B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
Brognard J, Clark AS, Ni Y and Dennis PA: Akt/protein B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61: 3986-3997, 2001. (Pubitemid 32720961)
-
(2001)
Cancer Research
, vol.61
, Issue.10
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
4
-
-
6044230919
-
Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
-
DOI 10.1158/1078-0432.CCR-04-0174
-
David O, Jett J, LeBean H, Dy G, Hughes J, Friedman M and Brody AR: Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 10: 6865-6871, 2004. (Pubitemid 39383035)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.20
, pp. 6865-6871
-
-
David, O.1
Jett, J.2
Lebeau, H.3
Dy, G.4
Hughes, J.5
Friedman, M.6
Brody, A.R.7
-
5
-
-
33750571668
-
Mutational analysis of AKT1, AKT2, and AKT3 genes in common human carcinomas
-
Soung YH, Lee JW, Nam SW, Lee JY, Yoo NJ and Lee SH: Mutational analysis of AKT1, AKT2, and AKT3 genes in common human carcinomas. Oncology 70: 285-289, 2006.
-
(2006)
Oncology
, vol.70
, pp. 285-289
-
-
Soung, Y.H.1
Lee, J.W.2
Nam, S.W.3
Lee, J.Y.4
Yoo, N.J.5
Lee, S.H.6
-
6
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
DOI 10.1038/nature05933, PII NATURE05933
-
Carpten JD, Faber AL, Horn C, et al: A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444, 2007. (Pubitemid 47123510)
-
(2007)
Nature
, vol.448
, Issue.7152
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
Uhlik, M.11
Lin, A.12
Du, J.13
Qian, Y.-W.14
Zeckner, D.J.15
Tucker-Kellogg, G.16
Touchman, J.17
Patel, K.18
Mousses, S.19
Bittner, M.20
Schevitz, R.21
Lai, M.-H.T.22
Blanchard, K.L.23
Thomas, J.E.24
more..
-
7
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, et al: Activating E17K mutation in the gene encoding the protein kinase AKT in a subset of squamous cell carcinoma of the lung. Cell Cycle 7: 665-669, 2008.
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
-
8
-
-
2342624080
-
EGFR mutations in lung, cancer: Correlation with clinical response to gefitinib therapy
-
DOI 10.1126/science.1099314
-
Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304: 1497-1500, 2004. (Pubitemid 38720929)
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
9
-
-
33644539850
-
Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay
-
DOI 10.1016/j.lungcan.2005.08.009, PII S0169500205004083
-
Endo K, Konishi A, Sasaki H, et al: Epidermal growth factor receptor gene mutation in non-small cell lung cancer using highly sensitive and fast TaqMan PCR assay. Lung Cancer 50: 375-384, 2005. (Pubitemid 43300637)
-
(2005)
Lung Cancer
, vol.50
, Issue.3
, pp. 375-384
-
-
Endo, K.1
Konishi, A.2
Sasaki, H.3
Takada, M.4
Tanaka, H.5
Okumura, M.6
Kawahara, M.7
Sugiura, H.8
Kuwabara, Y.9
Fukai, I.10
Matsumura, A.11
Yano, M.12
Kobayashi, Y.13
Mizuno, K.14
Haneda, H.15
Suzuki, E.16
Iuchi, K.17
Fujii, Y.18
-
10
-
-
27944499351
-
EGFR and ErbB2 mutation status in Japanese lung cancer patients
-
DOI 10.1002/ijc.21301
-
Sasaki H, Shimizu S, Endo K, et al: EGFR and erbB2 mutation status in Japanese lung cancer patients. Int J Cancer 118: 180-184, 2006. (Pubitemid 41681596)
-
(2006)
International Journal of Cancer
, vol.118
, Issue.1
, pp. 180-184
-
-
Sasaki, H.1
Shimizu, S.2
Endo, K.3
Takada, M.4
Kawahara, M.5
Tanaka, H.6
Matsumura, A.7
Iuchi, K.8
Haneda, H.9
Suzuki, E.10
Kobayashi, Y.11
Yano, M.12
Fujii, Y.13
-
11
-
-
20244371965
-
EGFR mutation status in Japanese lung cancer patients: Genotyping analysis using lightcycler
-
DOI 10.1158/1078-0432.CCR-04-1904
-
Sasaki H, Endo K, Konishi A, et al: EGFR mutation status in Japanese lung cancer patients: genotyping analysis using LightCycler. Clin Cancer Res 11: 2924-2929, 2005. (Pubitemid 40525194)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.8
, pp. 2924-2929
-
-
Sasaki, H.1
Endo, K.2
Konishi, A.3
Takada, M.4
Kawahara, M.5
Iuchi, K.6
Matsumura, A.7
Okumura, M.8
Tanaka, H.9
Kawaguchi, T.10
Shimizu, T.11
Takeuchi, H.12
Yano, M.13
Fukai, I.14
Fujii, Y.15
-
13
-
-
0033152165
-
Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN
-
Davies MA, Koul D, Dhesi H, et al: Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res 59: 2551-2556, 1999. (Pubitemid 29269096)
-
(1999)
Cancer Research
, vol.59
, Issue.11
, pp. 2551-2556
-
-
Davies, M.A.1
Koul, D.2
Dhesi, H.3
Berman, R.4
McDonnell, T.J.5
McConkey, D.6
Yung, W.K.A.7
Steck, P.A.8
-
14
-
-
0035008874
-
Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression
-
DOI 10.1128/MCB.21.6.2203-2212.2001
-
Hutchinson J, Jin J, Cardiff RD, Woodgett JR and Muller WJ: Activation of Akt (protein B) in mammary epithelium provides a critical cell survival signal required for tumor progression. Mol Cell Biol 21: 2203-2212, 2001. (Pubitemid 32479640)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.6
, pp. 2203-2212
-
-
Hutchinson, J.1
Jin, J.2
Cardiff, R.D.3
Woodgett, J.R.4
Muller, W.J.5
-
15
-
-
0035971181
-
Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
-
DOI 10.1074/jbc.M010840200
-
Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S and Nakshatri H: Phosphatidylinositol 3-kinase/Aktmediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance. J Biol Chem 276: 9817-9824, 2001. (Pubitemid 37391881)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.13
, pp. 9817-9824
-
-
Campbell, R.A.1
Bhat-Nakshatri, P.2
Patel, N.M.3
Constantinidou, D.4
Ali, S.5
Nakshatri, H.6
-
16
-
-
0032534025
-
The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70(s6k)-dependent pathway
-
Moore SM, Rintoul RC, Walker TR, Chilvers ER, Haslett C and Sethi T: The presence of a constitutively active phosphoinositide 3-kinase in small cell lung cancer cells mediates anchorage-independent proliferation via a protein kinase B and p70s6k-dependent pathway. Cancer Res 58: 5239-5247, 1998. (Pubitemid 28521188)
-
(1998)
Cancer Research
, vol.58
, Issue.22
, pp. 5239-5247
-
-
Moore, S.M.1
Rintoul, R.C.2
Walker, T.R.3
Chilvers, E.R.4
Haslett, C.5
Sethi, T.6
-
17
-
-
0034665134
-
Prevention of phosphatidylinositol 3'-kinase-Akt survival signaling pathway during topotecan-induced apoptosis
-
Nakashio A, Fujita N, Rokudai S, Sato S and Tsuruo T: Prevention of phosphatidylinositol 3′-kinase-Akt survival signaling pathway during topotecan-induced apoptosis. Cancer Res 60: 5303-5309, 2000. (Pubitemid 30739793)
-
(2000)
Cancer Research
, vol.60
, Issue.18
, pp. 5303-5309
-
-
Nakashio, A.1
Fujita, N.2
Rokudai, S.3
Sato, S.4
Tsuruo, T.5
-
18
-
-
11144358645
-
High Frequency of Mutations of the PIK3CA Gene in Human Cancers
-
DOI 10.1126/science.1096502
-
Samuels Y, Wang Z, Bardelli A, et al: High frequency of mutations of the PIK3CA gene in human cancers. Science 304: 554, 2004. (Pubitemid 38541907)
-
(2004)
Science
, vol.304
, Issue.5670
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Yan, H.7
Gazdar, A.8
Powell, S.M.9
Riggins, G.J.10
Willson, J.K.V.11
Markowitz, S.12
Kinzler, K.W.13
Vogelstein, B.14
Velculescu, V.E.15
-
19
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
DOI 10.1016/j.lungcan.2006.07.006, PII S0169500206003576
-
Kawano O, Sasaki H, Endo K, et al: PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 54: 209-215, 2006. (Pubitemid 44764916)
-
(2006)
Lung Cancer
, vol.54
, Issue.2
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
Suzuki, E.4
Haneda, H.5
Yukiue, H.6
Kobayashi, Y.7
Yano, M.8
Fujii, Y.9
-
20
-
-
34548446446
-
PIK3CA mutation and amplification in human lung cancer
-
DOI 10.1111/j.1440-1827.2007.02155.x
-
Okudera K, Suzuki M, Kageyama S, et al: PIK3CA mutation and amplification in human lung cancer. Pathol Int 57: 664-671, 2007. (Pubitemid 47353042)
-
(2007)
Pathology International
, vol.57
, Issue.10
, pp. 664-671
-
-
Okudela, K.1
Suzuki, M.2
Kageyama, S.3
Bunai, T.4
Nagura, K.5
Igarashi, H.6
Takamochi, K.7
Suzuki, K.8
Yamada, T.9
Niwa, H.10
Ohashi, R.11
Ogawa, H.12
Mori, H.13
Kitamura, H.14
Kaneko, T.15
Tsuneyoshi, T.16
Sugimura, H.17
-
21
-
-
0037086001
-
Living with lethal PIP3 levels: Viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB
-
DOI 10.1126/science. 1068094
-
Stocker H, Andjelkovic M, Oldham S, et al: Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB. Science 295: 2088-2091, 2002. (Pubitemid 34229473)
-
(2002)
Science
, vol.295
, Issue.5562
, pp. 2088-2091
-
-
Stocker, H.1
Andjelkovic, M.2
Oldham, S.3
Laffargue, M.4
Wymann, M.P.5
Hemmings, B.A.6
Hafen, E.7
-
22
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
Franke TF, Yang SI, Chan TO, et al: The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736, 1995.
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
-
23
-
-
0034604067
-
Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer
-
Yuan ZQ, Sun M, Feldman RI, et al: Frequent activation of Akt2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene 19: 2324-2330, 2000. (Pubitemid 30307208)
-
(2000)
Oncogene
, vol.19
, Issue.19
, pp. 2324-2330
-
-
Zeng, Q.Y.1
Sun, M.2
Feldman, R.I.3
Wang, G.4
Ma, X.-L.5
Jiang, C.6
Coppola, D.7
Nicosia, S.V.8
Cheng, J.Q.9
-
24
-
-
0001457668
-
Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
-
DOI 10.1073/pnas.93.8.3636
-
Cheng JQ, Ruggeri B, Klein WM, Sonoda G, Altomare DA, Watson DK and Testa JR: Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenecity by antisense RNA. Proc Natl Acad Sci USA 93: 3636-3641, 1996. (Pubitemid 26127592)
-
(1996)
Proceedings of the National Academy of Sciences of the United States of America
, vol.93
, Issue.8
, pp. 3636-3641
-
-
Cheng, J.Q.1
Ruggeri, B.2
Klein, W.M.3
Sonoda, G.4
Altomare, D.A.5
Watson, D.K.6
Testa, J.R.7
-
25
-
-
1142277821
-
Akt2 expression correlates with prognosis of human hepatocellular carcinoma
-
Xu X, Sakon M, Nagano H, et al: Akt2 expression correlates with prognosis of human hepatocellular carcinoma. Oncol Rep 11: 25-32, 2004.
-
(2004)
Oncol Rep
, vol.11
, pp. 25-32
-
-
Xu, X.1
Sakon, M.2
Nagano, H.3
-
26
-
-
33646791858
-
Uncommon V599E mutations in Japanese patients with lung cancer
-
Sasaki H, Kawano O, Endo K, et al: Uncommon V599E mutations in Japanese patients with lung cancer. J Surg Res 133: 203-206, 2006.
-
(2006)
J Surg Res
, vol.133
, pp. 203-206
-
-
Sasaki, H.1
Kawano, O.2
Endo, K.3
-
27
-
-
38449107131
-
Nras and Kras mutation in Japanese lung cancer patients: Genotyping analysis using LightCycler
-
Sasaki H, Okuda K, Kawano O, et al: Nras and Kras mutation in Japanese lung cancer patients: genotyping analysis using LightCycler. Oncol Rep 18: 623-628, 2007.
-
(2007)
Oncol Rep
, vol.18
, pp. 623-628
-
-
Sasaki, H.1
Okuda, K.2
Kawano, O.3
|