Latent effects of fibronectin, α5β1 integrin, αVβ5 integrin and the cytoskeleton regulate pancreatic carcinoma cell IL-8 secretion

British Journal of Cancer

Volumn 91, Issue 7, 2004, Pages 1327-1334

  Lowrie, A G ^a   Salter, D M ^b   Ross, J A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cytoskeleton; Extracellular matrix; Integrins; Interleukin 8; Pancreatic cancer

Indexed keywords

ALPHAVBETA5 INTEGRIN; BETA5 INTEGRIN; CD51 ANTIGEN; CYTOCHALASIN D; FIBRONECTIN; INTERLEUKIN 8; SCLEROPROTEIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; INTEGRIN; VITRONECTIN RECEPTOR;

ARTICLE; CANCER CELL; CANCER GROWTH; CELL PROLIFERATION; CELL SPREADING; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSKELETON; DOSE RESPONSE; HUMAN; HUMAN CELL; PANCREAS CARCINOMA; PRIORITY JOURNAL; CARCINOMA; CELL COMMUNICATION; CELL CULTURE; DISEASE COURSE; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; SECRETION; SIGNAL TRANSDUCTION;

CARCINOMA; CELL COMMUNICATION; CYTOSKELETON; DISEASE PROGRESSION; FIBRONECTINS; HUMANS; INTEGRIN ALPHA5BETA1; INTEGRINS; INTERLEUKIN-8; PANCREATIC NEOPLASMS; RECEPTORS, VITRONECTIN; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 6944244109     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602132     Document Type: Article

References (57)

1. Anaya-Prado R, Toledo-Pereyra LH, Collins JT, Smejkal R, McClaren J, Crouch LD, Ward PA (1998) Dual blockade of P-selectin and beta2-integrin in the liver inflammatory response after uncontrolled hemorrhagic shock. J Am Coll Surg 187: 22-31
2. Armstrong PB, Armstrong MT (2000) Intercellular invasion and the organizational stability of tissues: a role for fibronectin. Biochim Biophys Acta 1470: O9-20
3. Arroyo AG, Sanchez-Mateos P, Campanero MR, Martin-Padura I, Dejana E, Sanchez-Madrid F (1992) Regulation of the VLA integrin-ligand interactions through the beta 1 subunit. J Cell Biol 117: 659-670
4. Bax DV, Bernard SE, Lomas A, Morgan A, Humphries J, Shuttleworth CA, Humphries MJ, Kielty CM (2003) Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. J Biol Chem 278: 34605-34616
5. Bellone G, Turletti A, Artusio E, Mareschi K, Carbone A, Tibaudi D, Robecchi A, Emanuelli G, Rodeck U (1999) Tumor-associated transforming growth factor-beta and interleukin-10 contribute to a systemic Th2 immune phenotype in pancreatic carcinoma patients. Am J Pathol 155: 537-547
6. Boudreau NJ, Jones PL (1999) Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 339(Part 3): 481-488
7. Brakebusch C, Bouvard D, Stanchi F, Sakai T, Fassler R (2002) Integrins in invasive growth. J Clin Invest 109: 999-1006
8. Bruns CJ, Harbison MT, Kuniyasu H, Eue I, Fidler IJ (1999) In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia 1: 50-62
9. Crawford HC, Matrisian LM (1996) Mechanisms controlling the transcription of matrix metalloproteinase genes in normal and neoplastic cells. Enzyme Protein 49: 20-37
10. Cui X, Lee AV (2004) Regulatory nodes that integrate and coordinate signaling as potential targets for breast cancer therapy. Clin Cancer Res 10: 396S-401S
11. Danen EH, Sonneveld P, Brakebusch C, Fassler R, Sonnenberg A (2002) The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis. J Cell Biol 159: 1071-1086
12. Danen EH, Ten Berge PJ, Van Muijen GN, Van't Hof-Grootenboer AE, Brocker EB, Ruiter DJ (1994) Emergence of alpha 5 beta 1 fibronectin- and alpha v beta 3 vitronectin-receptor expression in melanocytic tumour progression. Histopathology 24: 249-256
13. Danen EH, Yamada KM (2001) Fibronectin, integrins, and growth control. J Cell Physiol 189: 1-13
14. de Waal Malefyt R, Abrams J, Bennett B, Figdor CG, de Vries JE (1991) Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 174: 1209-1220
15. Di Sebastiano P, di Mola FF, Di Febbo C, Baccante G, Porreca E, Innocenti P, Friess H, Buchler MW (2000) Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis. Gut 47: 423-428
16. Eierman DF, Johnson CE, Haskill JS (1989) Human monocyte inflammatory mediator gene expression is selectively regulated by adherence substrates. J Immunol 142: 1970-1976
17. Geppert TD, Lipsky PE (1990) Regulatory role of microfilaments in the induction of T4 cell proliferation and interleukin 2 production. Cell Immunol 131: 205-218
18. Gress TM, Muller-Pillasch F, Lerch MM, Friess H, Buchler M, Adler G (1995) Expression and in situ localization of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in pancreatic cancer. Int J Cancer 62: 407-413
19. Hattar K, Fink L, Fietzner K, Himmel B, Grimminger F, Seeger W, Sibelius U (2001) Cell density regulates neutrophil IL-8 synthesis: role of IL-1 receptor antagonist and soluble TNF receptors. J Immunol 166: 6287-6293
20. Horton MA, Lewis D, McNulty K, Pringle JA, Chambers TJ (1985) Monoclonal antibodies to osteoclastomas (giant cell bone tumors): definition of osteoclast-specific cellular antigens. Cancer Res 45: 5663-5669
21. Horwitz A, Duggan K, Buck C, Beckerle MC, Burridge K (1986) Interaction of plasma membrane fibronectin receptor with talin - a transmembrane linkage. Nature 320: 531-533
22. Hynes RO (2002) Integrins: bidirectional, allosteric signaling machines. Cell 110: 673-687
23. Juliano RL, Varner JA (1993) Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol 5: 812-818
24. Le X, Shi Q, Wang B, Xiong Q, Qian C, Peng Z, Li XC, Tang H, Abbruzzese JL, Xie K (2000) Molecular regulation of constitutive expression of interleukin-8 in human pancreatic adenocarcinoma. J Interferon Cytokine Res 20: 935-946
25. Liotta LA, Kohn EC (2001) The microenvironment of the tumour-host interface. Nature 411: 375-379
26. Lubin FD, Segal M, McGee DW (2003) Regulation of epithelial cell cytokine responses by the alpha3beta1 integrin. Immunology 108: 204-210
27. Lupetti R, Mortarini R, Panceri P, Sensi M, Anichini A (1996) Interaction with fibronectin regulates cytokine gene expression in human melanoma cells. Int J Cancer 66: 110-116
28. Maheshwari G, Wells A, Griffith LG, Lauffenburger DA (1999) Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration. Biophys J 76: 2814-2823
29. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Vande Woude GF, Ahn NG (1994) Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265: 966-970
30. Marshall JF, Rutherford DC, McCartney AC, Mitjans F, Goodman SL, Hart IR (1995) Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin. J Cell Sci 108(Part 3): 1227-1238
31. Mendez-Samperio P, Garcia E, Vazquez A, Palma J (2002) Regulation of interleukin-8 by interleukin-10 and transforming growth factor beta in human monocytes infected with Mycobacterium bovis. Clin Diagn Lab Immunol 9: 802-807
32. Miyamoto S, Akiyama SK, Yamada KM (1995) Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function. Science 267: 883-885
33. Miyamoto S, Teramoto H, Gutkind JS, Yamada KM (1996) Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol 135: 1633-1642
34. Mizejewski GJ (1999) Role of integrins in cancer: survey of expression patterns. Proc Soc Exp Biol Med 222: 124-138
35. Nicolas FJ, Hill CS (2003) Attenuation of the TGF-beta-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-beta-induced growth arrest. Oncogene 22: 3698-3711
36. Otey CA, Pavalko FM, Burridge K (1990) An interaction between alpha-actinin and the beta 1 integrin subunit in vitro. J Cell Biol 111: 721-729
37. Perruzzi CA, de Fougerolles AR, Koteliansky VE, Whelan MC, Westlin WF, Senger DR (2003) Functional overlap and cooperativity among alphav and beta1 integrin subfamilies during skin angiogenesis. J Invest Dermatol 120: 1100-1109
38. Pupa SM, Menard S, Forti S, Tagliabue E (2002) New insights into the role of extracellular matrix during tumor onset and progression. J Cell Physiol 192: 259-267
39. Pytela R, Pierschbacher MD, Ruoslahti E (1985) A 125/115-kDa cell surface receptor specific for vitronectin interacts with the arginine-glycine-aspartic acid adhesion sequence derived from fibronectin. Proc Natl Acad Sci USA 82: 5766-5770
40. Radisky D, Hagios C, Bissell MJ (2001) Tumors are unique organs defined by abnormal signaling and context. Semin Cancer Biol 11: 87-95
41. Rettig WJ, Erickson HP, Albino AP, Garin-Chesa P (1994) Induction of human tenascin (neuronectin) by growth factors and cytokines: cell type-specific signals and signalling pathways. J Cell Sci 107(Part 2): 487-497
42. Riedl SE, Faissner A, Schlag P, Von Herbay A, Koretz K, Moller P (1992) Altered content and distribution of tenascin in colitis, colon adenoma, and colorectal carcinoma. Gastroenterology 103: 400-406
43. Saren P, Welgus HG, Kovanen PT (1996) TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages. J Immunol 157: 4159-4165
44. Schlaepfer DD, Hanks SK, Hunter T, van der Geer P (1994) Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786-791
45. Shi Q, Abbruzzese JL, Huang S, Fidler IJ, Xiong Q, Xie K (1999) Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res 5: 3711-3721
46. Shi Q, Xiong Q, Le X, Xie K (2001) Regulation of interleukin-8 expression by tumor-associated stress factors. J Interferon Cytokine Res 21: 553-566
47. Streuli C (1999) Extracellular matrix remodelling and cellular differentiation. Curr Opin Cell Biol 11: 634-640
48. Stupack DG, Cheresh DA (2002) Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115: 3729-3738
49. Takizawa T, Nishinarita S, Kitamura N, Hayakawa J, Kang H, Tomita Y, Mitamura K, Yamagami K, Horie T (1995) Interaction of the cell-binding domain of fibronectin with VLA-5 integrin induces monokine production in cultured human monocytes. Clin Exp Immunol 101: 376-382
50. Taverna D, Ullman-Cullere M, Rayburn H, Bronson RT, Hynes RO (1998) A test of the role of alpha5 integrin/fibronectin interactions in tumorigenesis. Cancer Res 58: 848-853
51. Tomatis D, Echtermayer F, Schober S, Balzac F, Retta SF, Silengo L, Tarone G (1999) The muscle-specific laminin receptor alpha7 beta1 integrin negatively regulates alpha5 beta1 fibronectin receptor function. Exp Cell Res 246: 421-432
52. Wigmore SJ, Fearon KC, Maingay JP, Lai PB, Ross JA (1997) Interleukin-8 can mediate acute-phase protein production by isolated human hepatocytes. Am J Physiol 273: E720-6
53. Wigmore SJ, Fearon KC, Sangster K, Maingay JP, Garden OJ, Ross JA (2002) Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. Int J Oncol 21: 881-886
54. Wilmer JL, Luster MI (1995) Chemical induction of interleukin-8, a proinflammatory chemokine, in human epidermal keratinocyte cultures and its relation to cytogenetic toxicity. Cell Biol Toxicol 11: 37-50
55. Xie K (2001) Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 12: 375-391
56. Yamada KM, Miyamoto S (1995) Integrin transmembrane signaling and cytoskeletal control. Curr Opin Cell Biol 7: 681-689
57. Zachary I, Rozengurt E (1992) Focal adhesion kinase (p125FAK): a point of convergence in the action of neuropeptides, integrins, and oncogenes. Cell 71: 891-894