메뉴 건너뛰기




Volumn 15, Issue 16, 2009, Pages 5101-5107

Elevated cutaneous smad activation associates with enhanced skin tumor susceptibility in organ transplant recipients

Author keywords

[No Author keywords available]

Indexed keywords

ANTIREJECTION AGENT; BONE MORPHOGENETIC PROTEIN RECEPTOR; IMMUNOSUPPRESSIVE AGENT; SMAD PROTEIN; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; UNCLASSIFIED DRUG;

EID: 69349103707     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-08-3286     Document Type: Article
Times cited : (11)

References (50)
  • 1
    • 27144510955 scopus 로고    scopus 로고
    • Non-melanoma skin cancer: What drives tumor development and progression?
    • Boukamp P. Non-melanoma skin cancer: what drives tumor development and progression? Carcinogenesis 2005;26:1657-1667
    • (2005) Carcinogenesis , vol.26 , pp. 1657-1667
    • Boukamp, P.1
  • 2
    • 34748812496 scopus 로고    scopus 로고
    • Management of solid tumours in organ-transplant recipients
    • DOI 10.1016/S1470-2045(07)70315-7, PII S1470204507703157
    • Ajithkumar TV, Parkinson CA, Butler A, Hatcher HM. Management of solid tumours in organ-transplant recipients. Lancet Oncol 2007;8: 921-932 (Pubitemid 47488067)
    • (2007) Lancet Oncology , vol.8 , Issue.10 , pp. 921-932
    • Ajithkumar, T.V.1    Parkinson, C.A.2    Butler, A.3    Hatcher, H.M.4
  • 4
    • 0028957981 scopus 로고
    • Aggressive squamous cell carcinomas in organ transplant recipients
    • Euvrard S, Kanitakis J, Pouteil-Noble C, et al. Aggressive squamous cell carcinomas in organ transplant recipients. Transplant Proc 1995;27: 1767-1768
    • (1995) Transplant Proc , vol.27 , pp. 1767-1768
    • Euvrard, S.1    Kanitakis, J.2    Pouteil-Noble, C.3
  • 9
    • 33845711356 scopus 로고    scopus 로고
    • Cancer incidence before and after kidney transplantation
    • Vajdic CM, McDonald SP, McCredie MR, et al. Cancer incidence before and after kidney transplantation. JAMA 2006;296:2823-2831
    • (2006) JAMA , vol.296 , pp. 2823-2831
    • Vajdic, C.M.1    McDonald, S.P.2    McCredie, M.R.3
  • 12
    • 0037182139 scopus 로고    scopus 로고
    • Rapamycin blocks tumor progression: Unlinking immunosuppression from antitumor efficacy
    • Luan FL, Hojo M, Maluccio M, Yamaji K, Suthanthiran M. Rapamycin blocks tumor progression: unlinking immunosuppression from antitumor efficacy. Transplantation 2002;73: 1565-1572 (Pubitemid 34568667)
    • (2002) Transplantation , vol.73 , Issue.10 , pp. 1565-1572
    • Luan, F.L.1    Hojo, M.2    Maluccio, M.3    Yamaji, K.4    Suthanthiran, M.5
  • 14
    • 51749107469 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A
    • Wulff BC, Kusewitt DF, VanBuskirk AM, Thomas-Ahner JM, Duncan FJ, Oberyszyn TM. Sirolimus reduces the incidence and progression of UVB-induced skin cancer in SKH mice even with co-administration of cyclosporine A. J Invest Dermatol 2008;128:2467-2473
    • (2008) J Invest Dermatol , vol.128 , pp. 2467-2473
    • Wulff, B.C.1    Kusewitt, D.F.2    VanBuskirk, A.M.3    Thomas-Ahner, J.M.4    Duncan, F.J.5    Oberyszyn, T.M.6
  • 18
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • DOI 10.1038/ng1001-117
    • Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-129 (Pubitemid 32952643)
    • (2001) Nature Genetics , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 19
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • DOI 10.1038/nature02006
    • Derynck R, Zhang YE. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 2003;425:577-584 (Pubitemid 37280136)
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 20
    • 0024593615 scopus 로고
    • Transforming growth factor-β1: Histochemical localization with antibodies to different epitopes
    • Flanders KC, Thompson NL, Cissel DS, et al. Transforming growth factor-β1: histochemical localization with antibodies to different epitopes. J Cell Biol 1989;108:653-660
    • (1989) J Cell Biol , vol.108 , pp. 653-660
    • Flanders, K.C.1    Thompson, N.L.2    Cissel, D.S.3
  • 21
    • 36448936383 scopus 로고    scopus 로고
    • TGFβ-SMAD signal transduction: Molecular specificity and functional flexibility
    • DOI 10.1038/nrm2297, PII NRM2297
    • Schmierer B, Hill CS. TGFβ-SMAD signal transduction: molecular specificity and functional flexibility. Nat Rev Mol Cell Biol 2007;8: 970-982 (Pubitemid 350174642)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.12 , pp. 970-982
    • Schmierer, B.1    Hill, C.S.2
  • 22
    • 0036038264 scopus 로고    scopus 로고
    • Ultraviolet irradiation alters transforming growth factor β/Smad pathway in human skin in vivo
    • DOI 10.1046/j.1523-1747.2002.01834.x
    • Quan T, He T, Kang S, Voorhees JJ, Fisher GJ. Ultraviolet irradiation alters transforming growth factor β/smad pathway in human skin in vivo. J Invest Dermatol 2002;119:499-506. (Pubitemid 35001963)
    • (2002) Journal of Investigative Dermatology , vol.119 , Issue.2 , pp. 499-506
    • Quan, T.1    He, T.2    Kang, S.3    Voorhees, J.J.4    Fisher, G.J.5
  • 23
    • 4344670210 scopus 로고    scopus 로고
    • Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-β type II receptor/Smad signaling
    • Quan T, He T, Kang S, Voorhees JJ, Fisher GJ. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-β type II receptor/Smad signaling. Am J Pathol 2004;165:741-751 (Pubitemid 39129282)
    • (2004) American Journal of Pathology , vol.165 , Issue.3 , pp. 741-751
    • Quan, T.1    He, T.2    Kang, S.3    Voorhees, J.J.4    Fisher, G.J.5
  • 24
    • 16244393433 scopus 로고    scopus 로고
    • Alteration of the TGF-β/SMAD pathway in intrinsically and UV-induced skin aging
    • Han KH, Choi HR, Won CH, et al. Alteration of the TGF-β/SMAD pathway in intrinsically and UV-induced skin aging. Mech Ageing Dev 2005; 126:560-567
    • (2005) Mech Ageing Dev , vol.126 , pp. 560-567
    • Han, K.H.1    Choi, H.R.2    Won, C.H.3
  • 26
    • 0032519407 scopus 로고    scopus 로고
    • In vivo expression of transforming growth factor-β1 in humans: Stimulation by cyclosporine
    • Shin GT, Khanna A, Ding R, et al. In vivo expression of transforming growth factor-β1 in humans: stimulation by cyclosporine. Transplantation 1998;65:313-318
    • (1998) Transplantation , vol.65 , pp. 313-318
    • Shin, G.T.1    Khanna, A.2    Ding, R.3
  • 28
    • 0030598681 scopus 로고    scopus 로고
    • TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • DOI 10.1016/S0092-8674(00)80127-0
    • Cui W, Fowlis DJ, Bryson S, et al. TGFβ1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 1996;86:531-542 (Pubitemid 26299485)
    • (1996) Cell , vol.86 , Issue.4 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3    Duffie, E.4    Ireland, H.5    Balmain, A.6    Akhurst, R.J.7
  • 29
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002;4:487-494 (Pubitemid 34752433)
    • (2002) Nature Cell Biology , vol.4 , Issue.7 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 30
    • 3042778716 scopus 로고    scopus 로고
    • Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation
    • DOI 10.1158/0008-5472.CAN-04-1032
    • Lu SL, Reh D, Li AG, et al. Overexpression of transforming growth factor β1 in head and neck epithelia results in inflammation, angiogenesis, and epithelial hyperproliferation. Cancer Res 2004;64:4405-4410 (Pubitemid 38856909)
    • (2004) Cancer Research , vol.64 , Issue.13 , pp. 4405-4410
    • Lu, S.-L.1    Reh, D.2    Li, A.G.3    Woods, J.4    Corless, C.L.5    Kulesz-Martin, M.6    Wang, X.-J.7
  • 31
    • 33745164647 scopus 로고    scopus 로고
    • In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats
    • Ohsawa I, Murakami T, Uemoto S, Kobayashi E. In vivo luminescent imaging of cyclosporin A-mediated cancer progression in rats. Transplantation 2006;81:1558-1567
    • (2006) Transplantation , vol.81 , pp. 1558-1567
    • Ohsawa, I.1    Murakami, T.2    Uemoto, S.3    Kobayashi, E.4
  • 33
    • 48749122568 scopus 로고    scopus 로고
    • Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression
    • Hoot KE, Lighthall J, Han G, et al. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest 2008;118:2722-2732
    • (2008) J Clin Invest , vol.118 , pp. 2722-2732
    • Hoot, K.E.1    Lighthall, J.2    Han, G.3
  • 34
    • 35148832173 scopus 로고    scopus 로고
    • Loss of TGFβ Signaling Destabilizes Homeostasis and Promotes Squamous Cell Carcinomas in Stratified Epithelia
    • DOI 10.1016/j.ccr.2007.08.020, PII S1535610807002395
    • Guasch G, Schober M, Pasolli HA, Conn EB, Polak L, Fuchs E. Loss of TGFβ signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 2007;12:313-327 (Pubitemid 47539305)
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 313-327
    • Guasch, G.1    Schober, M.2    Pasolli, H.A.3    Conn, E.B.4    Polak, L.5    Fuchs, E.6
  • 35
    • 11144256945 scopus 로고    scopus 로고
    • Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: Potential of therapeutic applications
    • DOI 10.1161/01.CIR.0000150400.15354.7D
    • Khanna AK, Plummer MS, Hilton G, Pieper GM, Ledbetter S. Anti-transforming growth factor antibody at low but not high doses limits cyclosporine-mediated nephrotoxicity without altering rat cardiac allograft survival: potential of therapeutic applications. Circulation 2004; 110:3822-3829 (Pubitemid 40023981)
    • (2004) Circulation , vol.110 , Issue.25 , pp. 3822-3829
    • Khanna, A.K.1    Plummer, M.S.2    Hilton, G.3    Pieper, G.M.4    Ledbetter, S.5
  • 36
    • 0025632985 scopus 로고
    • Recombinant latent transforming growth factor β1 has a longer plasma half-life in rats than active transforming growth factor β1, and a different tissue distribution
    • Wakefield LM, Winokur TS, Hollands RS, Christopherson K, Levinson AD, Sporn MB. Recombinant latent transforming growth factor β1 has a longer plasma half-life in rats than active transforming growth factor β1, and a different tissue distribution. J Clin Invest 1990;86: 1976-1984
    • (1990) J Clin Invest , vol.86 , pp. 1976-1984
    • Wakefield, L.M.1    Winokur, T.S.2    Hollands, R.S.3    Christopherson, K.4    Levinson, A.D.5    Sporn, M.B.6
  • 37
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • DOI 10.1038/ncb975
    • Di Guglielmo GM, Le Roy C, Goodfellow AF, Wrana JL. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat Cell Biol 2003;5:410-421 (Pubitemid 36592263)
    • (2003) Nature Cell Biology , vol.5 , Issue.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 38
    • 33749246730 scopus 로고    scopus 로고
    • Mutations of TGFβ signaling molecules in human disease
    • DOI 10.1080/07853890600919911, PII M90747888816R3R0
    • Harradine KA, Akhurst RJ. Mutations of TGFβ signaling molecules in human disease. Ann Med 2006;38:403-414 (Pubitemid 44484878)
    • (2006) Annals of Medicine , vol.38 , Issue.6 , pp. 403-414
    • Harradine, K.A.1    Akhurst, R.J.2
  • 39
    • 0347991862 scopus 로고    scopus 로고
    • Integration of Smad and MAPK pathways: A link and a linker revisited
    • DOI 10.1101/gad.1167003
    • Massague J. Integration of Smad and MAPK pathways: a link and a linker revisited. Genes Dev 2003;17:2993-2997 (Pubitemid 38040762)
    • (2003) Genes and Development , vol.17 , Issue.24 , pp. 2993-2997
    • Massague, J.1
  • 41
    • 0030903515 scopus 로고    scopus 로고
    • In vivo hyperexpression of transforming growth factor-β1 in mice: Stimulation by cyclosporine
    • Khanna A, Kapur S, Sharma V, Li B, Suthanthiran M. In vivo hyperexpression of transforming growth factor-β1 in mice: stimulation by cyclosporine. Transplantation 1997;63: 1037-1039
    • (1997) Transplantation , vol.63 , pp. 1037-1039
    • Khanna, A.1    Kapur, S.2    Sharma, V.3    Li, B.4    Suthanthiran, M.5
  • 42
    • 69349103868 scopus 로고
    • On the origin of keratoacanthoma: Reflections on an unusual lesion
    • Fisher BK, Elliott GB. On the origin of keratoacanthoma: reflections on an unusual lesion. Can Med Assoc J 1965;93:272-273
    • (1965) Can Med Assoc J , vol.93 , pp. 272-273
    • Fisher, B.K.1    Elliott, G.B.2
  • 43
    • 33846000938 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion
    • DOI 10.1634/stemcells.2005-0544
    • Zhang J, He XC, Tong WG, et al. Bone morphogenetic protein signaling inhibits hair follicle anagen induction by restricting epithelial stem/progenitor cell activation and expansion. Stem Cells 2006;24:2826-2839 (Pubitemid 46053019)
    • (2006) Stem Cells , vol.24 , Issue.12 , pp. 2826-2839
    • Zhang, J.1    He, X.C.2    Tong, W.-G.3    Johnson, T.4    Wiedemann, L.M.5    Mishina, Y.6    Feng, J.Q.7    Li, L.8
  • 44
    • 38649106497 scopus 로고    scopus 로고
    • NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells
    • DOI 10.1016/j.cell.2007.11.047, PII S0092867407016145
    • Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell 2008;132: 299-310. (Pubitemid 351172432)
    • (2008) Cell , vol.132 , Issue.2 , pp. 299-310
    • Horsley, V.1    Aliprantis, A.O.2    Polak, L.3    Glimcher, L.H.4    Fuchs, E.5
  • 45
    • 38349098468 scopus 로고    scopus 로고
    • Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
    • Plikus MV, Mayer JA, de la Cruz D, et al. Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature 2008; 451:340-344
    • (2008) Nature , vol.451 , pp. 340-344
    • Plikus, M.V.1    Mayer, J.A.2    De La Cruz, D.3
  • 46
    • 0242425844 scopus 로고    scopus 로고
    • Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA
    • DOI 10.1083/jcb.200309042
    • Kobielak K, Pasolli HA, Alonso L, Polak L, Fuchs E. Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA. J Cell Biol 2003;163:609-623 (Pubitemid 37429873)
    • (2003) Journal of Cell Biology , vol.163 , Issue.3 , pp. 609-623
    • Kobielak, K.1    Pasolli, H.A.2    Alonso, L.3    Polak, L.4    Fuchs, E.5
  • 49
    • 33645672459 scopus 로고    scopus 로고
    • Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome
    • Habashi JP, Judge DP, Holm TM, et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 2006;312:117-121
    • (2006) Science , vol.312 , pp. 117-121
    • Habashi, J.P.1    Judge, D.P.2    Holm, T.M.3
  • 50
    • 27144458232 scopus 로고    scopus 로고
    • Topical application of a peptide inhibitor of transforming growth factor-β1 ameliorates bleomycin-induced skin fibrosis
    • Santiago B, Gutierrez-Canas I, Dotor J, et al. Topical application of a peptide inhibitor of transforming growth factor-β1 ameliorates bleomycin-induced skin fibrosis. J Invest Dermatol 2005;125:450-455
    • (2005) J Invest Dermatol , vol.125 , pp. 450-455
    • Santiago, B.1    Gutierrez-Canas, I.2    Dotor, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.