The nuclear appearance of ERK1/2 and p38 determines the sequential induction of ATF2-Thr71 and ATF2-Thr69 phosphorylation by serum in JNK-deficient cells

Molecular and Cellular Endocrinology

Volumn 311, Issue 1-2, 2009, Pages 94-100

  Baan, Bart ^a   van der Zon, Gerard C M ^a   Maassen, J Antonie ^a,b   Ouwens, D Margriet ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

ATF2; ERK1 2; Fibroblasts; p38; Serum

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; STRESS ACTIVATED PROTEIN KINASE; THREONINE;

ANIMAL CELL; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; EMBRYO; ENZYME ANALYSIS; ENZYME DEFICIENCY; FIBROBLAST; GENE ACTIVATION; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ACTIVATING TRANSCRIPTION FACTOR 2; ANIMALS; CELL NUCLEUS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PHOSPHOTHREONINE; PROTEIN TRANSPORT; PYRIDINES; SERUM; SIGNAL TRANSDUCTION;

EID: 69249232043     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.07.023     Document Type: Article

References (25)

1. Baan B., van Dam H., Van Der Zon G.C., Maassen J.A., and Ouwens D.M. The role of c-Jun N-terminal kinase, p38, and extracellular signal-regulated kinase in insulin-induced Thr69 and Thr71 phosphorylation of activating transcription factor 2. Mol. Endocrinol. 20 8 (2006) 1786-1795
2. Ban N., Yamada Y., Someya Y., Ihara Y., Adachi T., Kubota A., Watanabe R., Kuroe A., Inada A., Miyawaki K., Sunaga Y., Shen Z.P., Iwakura T., Tsukiyama K., Toyokuni S., Tsuda K., and Seino Y. Activating transcription factor-2 is a positive regulator in CaM kinase IV-induced human insulin gene expression. Diabetes 49 (2000) 1142-1148
3. Bhoumik A., Lopez-Bergami P., and Ronai Z. ATF2 on the double - activating transcription factor and DNA damage response protein. Pigment Cell Res. 20 (2007) 498-506
4. Cuenda A., Rouse J., Doza Y.N., Meier R., Cohen P., Gallagher T.F., Young P.R., and Lee J.C. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364 (1995) 229-233
5. De Ruiter N.D., Wolthuis R.M., van Dam H., Burgering B.M., and Bos J.L. Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway. Mol. Cell Biol. 20 (2000) 8480-8488
6. Favata M.F., Horiuchi K.Y., Manos E.J., Daulerio A.J., Stradley D.A., Feeser W.S., Van Dyk D.E., Pitts W.J., Earl R.A., Hobbs F., Copeland R.A., Magolda R.L., Scherle P.A., and Trzaskos J.M. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem. 273 (1998) 18623-18632
7. Hai T., and Curran T. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 3720-3724
8. Hai T., and Hartman M.G. The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273 (2001) 1-11
9. Hai T.W., Liu F., Coukos W.J., and Green M.R. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev. 3 (1989) 2083-2090
10. Kyriakis J.M., and Avruch J. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiol. Rev. 81 (2001) 807-869
11. Li X.Y., and Green M.R. Intramolecular inhibition of activating transcription factor-2 function by its DNA-binding domain. Genes Dev. 10 (1996) 517-527
12. Livingstone C., Patel G., and Jones N. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14 (1995) 1785-1797
13. Mayr B., and Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2 (2001) 599-609
14. Morton S., Davis R.J., and Cohen P. Signalling pathways involved in multisite phosphorylation of the transcription factor ATF-2. FEBS Lett. 572 (2004) 177-183
15. Ouwens D.M., De Ruiter N.D., Van Der Zon G.C., Carter A.P., Schouten J., Van Der Burgt C., Kooistra K., Bos J.L., Maassen J.A., and van Dam H. Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. EMBO J. 21 (2002) 3782-3793
16. Raingeaud J., Gupta S., Rogers J.S., Dickens M., Han J., Ulevitch R.J., and Davis R.J. Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270 (1995) 7420-7426
17. Rouse J., Cohen P., Trigon S., Morange M., Alonso-Llamazares A., Zamanillo D., Hunt T., and Nebreda A.R. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78 (1994) 1027-1037
18. Sabapathy K., Hochedlinger K., Nam S.Y., Bauer A., Karin M., and Wagner E.F. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 15 (2004) 713-725
19. Sakurai A., Maekawa T., Sudo T., Ishii S., and Kishimoto A. Phosphorylation of cAMP response element-binding protein, CRE-BP1, by cAMP-dependent protein kinase and protein kinase C. Biochem. Biophys. Res. Commun. 181 (1991) 629-635
20. Sanders J., Brandsma M., Janssen G.M., Dijk J., and Moller W. Immunofluorescence studies of human fibroblasts demonstrate the presence of the complex of elongation factor-1 beta gamma delta in the endoplasmic reticulum. J. Cell Sci. 109 (1996) 1113-1117
21. Sevilla A., Santos C.R., Vega F.M., and Lazo P.A. Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. J. Biol. Chem. 279 (2004) 27458-27465
22. van Dam H., and Castellazzi M. Distinct roles of Jun: Fos and Jun: ATF dimers in oncogenesis. Oncogene 20 (2001) 2453-2464
23. van Dam H., Wilhelm D., Herr I., Steffen A., Herrlich P., and Angel P. ATF-2 is preferentially activated by stress-activated protein kinases to mediate c-jun induction in response to genotoxic agents. EMBO J. 14 (1995) 1798-1811
24. Vlahopoulos S.A., Logotheti S., Mikas D., Giarika A., Gorgoulis V., and Zoumpourlis V. The role of ATF-2 in oncogenesis. Bioessays 30 (2008) 314-327
25. Waas W.F., Lo H.H., and Dalby K.N. The kinetic mechanism of the dual phosphorylation of the ATF2 transcription factor by p38 mitogen-activated protein (MAP) kinase alpha. Implications for signal/response profiles of MAP kinase pathways. J. Biol. Chem. 276 (2001) 5676-5684