Cleavage of group 1 coronavirus spike proteins: How furin cleavage is traded off against heparan sulfate binding upon cell culture adaptation

Journal of Virology

Volumn 82, Issue 12, 2008, Pages 6078-6083

  De Haan, C A M ^a   Haijema, B J ^a,b   Schellen, P ^a   Wichgers Schreur, P ^a   Te Lintelo, E ^a   Vennema, H ^a,c   Rottier, P J M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b INTERVET INTERNATIONAL BV   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; FURIN; HEPARAN SULFATE; SPIKE PROTEIN; VIRUS PROTEIN;

ADAPTATION; ANIMAL CELL; ARTICLE; BINDING SITE; CELL CULTURE; CONTROLLED STUDY; CORONAVIRUS; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MOTIF; VIRUS INFECTION; VIRUS MUTATION;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SEQUENCE; ANIMALS; CATS; CELL LINE; FURIN; HEPARITIN SULFATE; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA; VIRAL ENVELOPE PROTEINS;

CORONAVIRUS; FELINE CORONAVIRUS;

EID: 44949129907     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00074-08     Document Type: Article

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