Application of vibrational spectroscopy to the structural characterization of monoclonal antibody and its aggregate

Current Pharmaceutical Biotechnology

Volumn 10, Issue 4, 2009, Pages 391-399

  Li, Cynthia H ^a   Li, Tiansheng ^b  

^a AMGEN INC   (United States)

^b HTL Biosolutions Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; TRYPTOPHAN; TYROSINE; MULTIPROTEIN COMPLEX;

ANTIBODY PRODUCTION; DISULFIDE BOND; HEAT STRESS; INFRARED SPECTROSCOPY; INTERMETHOD COMPARISON; OPTICAL ROTATION; PH; PROCESS DEVELOPMENT; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; RAMAN SPECTROMETRY; REVIEW; SENSITIVITY AND SPECIFICITY; SHEAR STRESS; VALIDATION PROCESS; CHEMISTRY; FRACTIONATION; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; PHARMACEUTICS; SPECTROSCOPY; VIBRATION;

ANTIBODIES, MONOCLONAL; BIOPHARMACEUTICS; CHEMICAL FRACTIONATION; HUMANS; MULTIPROTEIN COMPLEXES; SPECTRUM ANALYSIS; TECHNOLOGY, PHARMACEUTICAL; VIBRATION;

EID: 69249209980     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109788488950     Document Type: Review

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