Pertussis toxin-sensitive G protein but not NO/cGMP pathway mediates the negative inotropic effect of carbachol in adult rat cardiomyocytes

Pharmacology

Volumn 70, Issue 1, 2004, Pages 46-56

  Sandirasegarane, Lakshman ^a,b   Diamond, Jack ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Adult rats; cAMP dependent protein kinase; Carbachol; cGMP; Isoproterenol; L NMMA; Negative inotropic effect; ODQ; Pertussis toxin sensitive G protein; Single ventricular myocyte contractility

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; BETA ADRENERGIC RECEPTOR; CARBACHOL; CYCLIC GMP; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANYLATE CYCLASE INHIBITOR; ISOPRENALINE; MUSCARINIC RECEPTOR BLOCKING AGENT; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PERTUSSIS TOXIN;

ADRENERGIC SYSTEM; ANIMAL CELL; ARTICLE; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; HEART MUSCLE CELL; HEART VENTRICLE WALL; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTILITY;

ADENYLATE CYCLASE; ANIMALS; CARBACHOL; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; ELECTRIC STIMULATION; FORSKOLIN; GTP-BINDING PROTEINS; INJECTIONS, INTRAPERITONEAL; ISOPROTERENOL; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; OXADIAZOLES; PERTUSSIS TOXIN; QUINOXALINES; RATS; TIME FACTORS;

EID: 0345491505     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000074242     Document Type: Article

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