Local cholinergic suppression of pacemaker activity in the rabbit sinoatrial node

Journal of Cardiovascular Pharmacology

Volumn 32, Issue 3, 1998, Pages 413-424

  Vinogradova, Tatiana M ^a   Fedorov, Vadim V ^a   Yuzyuk, Tatyana N ^a   Zaitsev, Alexey V ^a   Rosenshtraukh, Leonid V ^a  

^a INSTITUTE OF EXPERIMENTAL CARDIOLOGY   (Russian Federation)

Author keywords

Acetylcholine; Primary and subsidiary pacemaker cells; Sinoatrial node; Suppression of AP amplitude; Vagal stimulation

Indexed keywords

ACETYLCHOLINE; ATROPINE;

ACTION POTENTIAL; AMPLITUDE MODULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; MALE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SINUS NODE; TACHYCARDIA; VAGUS NERVE STIMULATION;

ACETYLCHOLINE; ACTION POTENTIALS; ANIMALS; MALE; RABBITS; SINOATRIAL NODE; VAGUS NERVE;

EID: 0031661768     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199809000-00012     Document Type: Article

References (44)

1. Masson-Pevet M, Bleeker WK, Besselsen E, Treytel BW, Jongsma HJ, Bouman LN. Pacemaker cell types in the rabbit sinus node: a correlative and electrophysiological study. J Mol Cell Cardiol 1984;16:53-63.
2. Bleeker WK, Mackaay AJ, Masson-Pevet M, Bouman LN, Becker A. Functional and morphological organization of the rabbit sinus node. Circ Res 1980;46:11-22.
3. Opthof T, Jonge B, Mackaay AJ, et al. Functional and morphological organization of guinea-pig sinoatrial node compared with rabbit sinoatrial node. J Mol Cell Cardiol 1985;17:549-64.
4. Kreitner D. Electrophysiological study of the two main pacemaker mechanisms in the rabbit sinus node. Cardiovasc Res 1985;19: 304-18.
5. Mackaay AJ, Op't Hof T, Bleeker WK, Jongsma HJ, Bouman LN. Interaction of adrenaline and acetylcholine on cardiac pacemaker function. J Pharmacol Exp Ther 1980;214:417-22.
6. Bouman LN, Gerlings ED, Biersteker PA, Bonke FIM. Pacemaker shift in the sino-atrial node during vagal stimulation. Pflugers Arch 1968;302:255-67.
7. Kodama I, Boyett MR, Suzuki R, Honjo H, Toyama J. Regional differences in the response of the isolated sino-atrial node of the rabbit to vagal stimulation. J Physiol 1996;495:785-801.
8. Honjo H, Boyett MR, Kodama I, Toyama J. Correlation between electrical activity and the size of rabbit sino-atrial node cells. J Physiol (Lond) 1996;496:795-808.
9. Nathan R. Two electrophysiologically distinct types of cultured pacemaker cells from the rabbit sinus node. Am J Physiol 1986; 250:H325-9.
10. Masson-Pevet M, Bleeker WK, Gros D. The plasma membrane of leading pacemaker cells in the rabbit sinus node. Circ Res 1979;45:621-9.
11. Anumonwo JMB, Wang E, Trabka-Janik E, et al. Gap junctional channels in adult mammalian sinus nodal cells: immunolocalization and electrophysiology. Circ Res 1992;71:229-39.
12. Duivenvoorden JJ, Bouman LN, Opthof T, Bukauskas FF, Jongsma HJ. Effect of transmural vagal stimulation on electrotonic current spread in the rabbit sinoatrial node. Cardiovasc Res 1992;26: 678-86.
13. Vinogradova TM, Yuzyuk TN, Zaitsev AV, Rosenshtraukh LV. Acetylcholine induces local inexcitability in the rabbit sinus node. J Mol Cell Cardiol 1996;28:A60.
14. Sano T, Yamagishi S. Spread of excitation from the sinus node. Circ Res 1965;16:423-30.
15. Vincenzi FF, West TC. Release of autonomie mediators in cardiac tissue by direct subthreshold electrical stimulation. J Pharmacol Exp Ther 1963;141:185-94.
16. Mazgalev T, Dreifus LS, Michelson EL, Pelleg AP. Effect of post-ganglionic vagal stimulation on the organization of atrioventricular nodal conduction in isolated rabbit heart tissue. Circulation 1986;74:869-80.
17. Hutter OF, Trautwein W. Vagal and sympathetic effects on the pacemaker fibers in the sinus venosus of the heart. J Gen Physiol 1956;39:715-33.
18. Loffelholz K, Pappano AJ. The parasympathetic neuroeffector junction of the heart. Pharmacol Rev 1985;37:1-24.
19. Paes de Carvalho A, Hoffman BF, Carvalho MP. Two components of the cardiac action potential. I. Voltage-time course and the effect of acetylcholine on atrial and nodal cells of the rabbit heart. J Gen Physiol 1969;54:607-35.
20. Shibata EF, Giles W, Pollack GH. Threshold effects of acetylcholine on primary pacemaker cells of the rabbit sino-atrial node. Proc R Soc Lond (Biol) 1985;223:355-78.
21. Campbell GD, Edwards FR, Hirst GDS, O'Shea E. Effects of vagal stimulation and applied acetylcholine on pacemaker potentials in the guinea-pig heart. J Physiol 1989;415:57-68.
22. Hirst GDS, Bramich NJ, Edwards FR, Klemm M. Transmission at autonomie neuroeffector junctions. TINS 1992;15:40-6.
23. Bramich NJ, Edwards FR, Hirst GDS. Ionophoretically applied acetylcholine and vagal stimulation in the arrested sinus venosus of the toad, Bufo marinus. J Physiol 1994;478:289-300.
24. Oosthoek PW, Viragh S, Mayen AEM, van Kempen MJA, Lamers WH, Moorman AFM. Immuno-histochemical delineation of the conduction system I: the sinoatrial node. Circ Res 1993;73:473-81.
25. Opthof T, de Jonge B, Jongsma HJ, Bouman LN. Functional morphology of the pig sinoatrial node. J Mol Cell Cardiol 1987;19: 1221-36.
26. Bouman LN, Jongsma HJ. Structure and function of the sino-atrial node: a review. Eur Heart J 1986;7:94-104.
27. Oei HI, Van Ginneken ACG, Jongsma HJ, Bouman LN. Mechanisms of impulse generation in isolated cells from the rabbit sinoatrial node. J Mol Cell Cardiol 1989;21:1137-49.
28. Doerr T, Denger R, Trautwein W. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflugers Arch 1989;413:599-603.
29. Irisawa H, Brown HF, Giles W. Cardiac pacemaking in the sinoatrial node. Physiol Rev 1993;73:197-227.
30. + current plays an important role in pacemaker activity in the periphery, but not the centre, of the rabbit sinoatrial node. J Physiol 1996;491:154P.
31. + currents in pacemaker activity in the sinoatrial node. Am J Physiol 1997;272:H2793-806.
32. + channels in isolated pacemaker cells of the mammalian heart. Nature 1983;303:250-3.
33. Petit-Jacques, Bois P, Bescond J, Lenfant J. Mechanism of muscarinic control of the high-threshold calcium current in rabbit sinoatrial node myocytes. Pflugers Arch 1993;423:21-7.
34. f) induced by acetylcholine in rabbit sino-atrial node myocytes. J Physiol (Lond) 1988;405:477-91.
35. Egan TM, Noble SJ. acetylcholine and the mammalian "slow inward" current: a computer investigation. Proc R Soc Lond (Biol) 1987;230:315-37.
36. DiFrancesco D, Ducouret P, Robinson RB. Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science 1989; 243:669-71.
37. Opthof T. The mammalian sino-atrial node. Cardiovasc Drug Ther 1988;1:573-97.
38. Vinogradova TM, Zaitsev AV, Kalyadin AYu, Sharifof OF, Rosenshtraukh LV. Acetylcholine provokes ectopic activity and reentry in isolated rabbit right atrium. Kardiologia (Russ) 1994;34:56-61.
39. Allessie MA, Lammers WJEP, Bonke IM, Hollen J. Inter-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog. Circulation 1984;70:123-35.
40. Hoffman BF, Cranefield PF. The physiological basis of cardiac arrhythmias. Am J Med 1964;37:670-84.
41. Rosen MR. Mechanisms for arrhythmias. Am J Physiol 1988; 61:2-8A.
42. Rosenshtraukh LV, Zaitsev AV, Fast VG, Pertsov AM, Krinsky VI. Vagally induced block and delayed conduction as a mechanism for circus movement tachycardia in frog atria. Circ Res 1989;64: 213-26.
43. Allessie MA, Bonke FIM. Direct demonstration of sinus node reentry in the rabbit heart. Circ Res 1979;44:557-68.
44. Alings AM, Bouman LN. Electrophysiology of the aging rabbit and cat sinoatrial node - a comparative study. Eur Heart J 1993;14: 1278-88.