Glucosinolates in crucifers and their potential effects against cancer: Review

Canadian Journal of Plant Science

Volumn 89, Issue 5, 2009, Pages 953-959

  Sarikamiş, Gölge ^a  

^a ANKARA UNIVERSITY   (Turkey)

Author keywords

Brassica; Crucifers; Glucosinolates

Indexed keywords

CANCER; HERB; HORTICULTURE; LEAFY VEGETABLE; ORGANIC COMPOUND;

BRASSICA; BRASSICA OLERACEA VAR. ITALICA;

EID: 69249148730     PISSN: 00084220     EISSN: None     Source Type: Journal    
DOI: 10.4141/CJPS08125     Document Type: Article

References (43)

1. Altundag, K., Gundeslioglu, O. and Altundag, O. 2006. Increased cabbage intake may inhibit metastatic and invasive capacity of breast cancer cells by inhibiting CXCL12 (SDF-1 alpha)/CXCR4. Med. Hypotheses 66: 672.
2. Bernardi, R., Negri, A., Ronchi, S. and Palmieri, S. 2000. Isolation of the epithiospecifier protein from oil-rape (Brassica napus spp. oleifera) seed and its characterisation. FEBS Lett. 467: 296-298.
3. Burow, M., Zang, Z-Y., Ober, J. A., Lambrix, V. M., Wittstock, U., Gershenzon, J. and Kliebenstein D. J. 2008. ESP and ESM1 mediate indol-3-acetonitrile production from indol-3-ylmethyl glucosinolate in Arabidopsis. Phytochemistry 69: 663-671.
4. Cartea, M. E., Velasco, P., Obregon, S., Padilla, G. and De Haro, A. 2008. Seasonal variation in glucosinolate content in Brassica oleracea crops grown in northwestern Spain. Phytochemistry 69: 403-410.
5. Chen, X., Zhu, Z., Ni, X. and Qian, Q. 2006. Effect of nitrogen and sulphur supply on glucosinolates in Brassica campestris ssp. chinensis. Agric. Sci. China. 5: 603-608.
6. Conaway, C. C, Getahun, S. M., Liebes, L. L., Pusateri, D. J., Topham, D. K., Botero-Omary, M. and Chung, F. L. 2000. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr. Cancer 38: 168-178.
7. Dinkova-Kostova, A. T., Holtzclaw, W. D., Cole, R. N., Itoh, K., Wakabayashi, N., Katoh, Y., Yamamoto, M. and Talalay, P. 2002. Direct evidence that sulfhydryl groups of keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. 99: 11908-11913.
8. Fahey, J. W., Zhang, Y. and Talalay, P. 1997. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proc. Nat. Acad. Sci. 94: 10367-10372.
9. Fowke, J. H., Chung, F. L., Jin, F., Qi, D., Cai, Q., Conaway, C, Cheng, J. R., Shu, X-O., Gao, Y-T. and Zheng, W. 2003. Urinary isothiocyanate levels, Brassica, and human breast cancer. Cancer Res. 63: 3980-3986.
10. Gills, J. J., Jeffery, E. H., Matusheski, N. V., Moon, R. C, Lantvit, D. D. and Pezzuto, J. M. 2006. Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett. 236: 72-79.
11. Hara, M., Hanaoka, T., Kobayashi, M., Otani, T., Adachi, H. Y., Montani, A., Natsukawa, S., Shaura, K., Koizumi, Y., Kasuga, Y., Matsuzawa, T., Ikekawa, T., Sasaki, S. and Tsugane, S. 2003. Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan. Nutr. Cancer 46: 138-147.
12. Hu, R., Khor, T. O., Shen, G., Jeong, W. S., Hebbar, V., Chen, C, Xu, C, Reddy, B., Chada, K. and Kong, A. N. 2006. Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable. Carcinogenesis 27: 2038-2046.
13. Joseph, M. A., Moysich, K. B., Freudenheim, J. L., Shields, P. G., Bowman, E. D., Zhang, Y., Marshall, J. R. and Ambrosone, C. B. 2004. Cruciferous vegetables, genetic polymorphisms in glutathione S-transferases M1 and T1, and prostate cancer risk. Nutr. Cancer 50: 206-213.
14. Juge, N., Mithen, R. F. and Traka, M. 2007. Molecular basis for chemoprevention by sulforaphane: a comprehensive review. Cell. Mol. Life Sci. 64: 1105-1127.
15. Lambrix, V., Reichelt, M., Mitchell-Olds, T., Kliebenstein, D. J. and Gershenzon, J. 2001. The Arabidopsis epithiospecifier protein promotes the hydrolysis of glucosinolates to nitriles and influences Trichoplusia ni herbivory. Plant Cell 13: 2793-2807.
16. Li, S., Schonhof, I., Krumbein, A., Li, L., Stutzel, H. and Schreiner, M. 2007. Glucosinolate concentration in Turnip (Brassica rapa ssp. rapifera L.) roots as affected by nitrogen and sulfur supply. J. Agric. Food Chem. 55: 8452-8457.
17. Lopez-Berenguer, C, Carvajal, M., Moreno, D. A. and Viguera, A. C. G. 2007. Effects of microwave cooking conditions on bioactive compounds present in Broccoli inflorescences. J. Agric. Food Chem. 55: 10001-10007.
18. Matusheski, N. V., Swarup, R., Juvik, J. A., Mithen, R., Bennett, M. and Jeffery, E. H. 2006. Epithiospecifier protein from broccoli (Brassica oleracea L. ssp. italica) inhibits formation of the anticancer agent sulforaphane J. Agric. Food Chem. 54: 2069-2076.
19. Matusheski, N. V., Juvik, J. A. and Jeffrey, E. H. 2004. Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli. Phytochemistry 265: 1273-1281.
20. Meyer, D. J., Crease, D. J. and Ketterer, B. 1995. Forward and reverse catalysis and product sequestration by human glutathione S-transferases in the reaction of GSH with dietary aralkyl isothiocyanates Biochem. J. 306: 565-569.
21. Mithen, R., Faulkner, K., Magrath, R., Rose, P., Williamson, G. and Marquez, J. 2003. Development of isothiocyanateenriched broccoli, and its enhanced ability to induce phase 2 detoxification enzymes in mammalian cells. Theor. Appl. Genet. 106: 727-734.
22. Moore, L. E., Brennan, P., Karami, S., Hung, R. J., Hsu, C., Boffetta, P., Toro, J., Zaridze, D., Janout, V., Bencko, V., Navratilova, M., Szeszenia-Dabrowska, N., Mates, D., Mukeria Holcatova, I., Welch, R., Chanock, S., Rothman, N. and Chow, W. H. 2007. Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study. Carcinogenesis 28: 1960-1964.
23. Munday, R., Mhawech-Fauceglia, P., Munday, C. M., Paonessa, J. D., Tang, L., Munday, J. S., Lister, C., Wilson, P., Fahey, J. W., Davis, W. and Zhang, Y. 2008. Inhibition of urinary bladder carcinogenesis by broccoli sprouts. Cancer Res. 68: 1593-1600.
24. Nachshon-Kedmi, M., Fares, F. A. and Yannai, S. 2004. Induction of apoptosis in human prostate cancer cell line, PC3, by 3′3′- diindolylmethane through the mitochondrial pathway. Prostate 61: 153-160.
25. Pereira, F. M., Rosa, E., Fahey, J. W., Stephenson, K. K., Carvalho, R. and Aires, A. 2002. Influence of temperature and ontogeny on the levels of glucosinolates in broccoli (Brassica oleracea var. italica) sprouts and their effect on the induction of mammalian phase 2 enzymes. J. Agric. Food Chem. 50: 6239-6244.
26. Robbins, R. J., Keck, A. S., Banuelos, G. and Finley, J. W. 2005. Cultivation conditions and selenium fertilization alter the phenolic profile, glucosinolate, and sulforaphane content of broccoli. J. Med. Food 8: 204-214.
27. Rose, P., Huang, O., Ong, C. N. and Whiteman, M. 2005. Broccoli and watercress suppress matrix metalloproteinase-9 activity and invasiveness of human MDA-MB-231 breast cancer cells. Toxicol. Appl. Pharmacol. 209: 10-113.
28. Rosen, C. J., Fritz, V. A., Gardner, G. M., Hecht, S. S., Carmella, S. G. and Kenney, P. M. 2005. Cabbage yield and glucosinolate concentrations as affected by nitrogen and sulphur fertility. Hort Science 40: 1493-1498.
29. Rungapamestry, V., Duncan, A. J. Fuller, Z. and Ratcliffe, B. 2006. Changes in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea var. capitata) cooked for different durations. J. Agric. Food Chem. 54: 7628-7634.
30. Sarikamiş, G., Marquez, J., Maccormack, A., Bennett, R., Roberts, J. and Mithen, R. 2006. High glucosinolate broccoli- A delivery system for sulforaphane. Mol. Breed. 18: 219-228.
31. Seow, A., Yuan, J. M., Sun, C. L., Van Den Berg, D., Lee, H. P. and Yu, M. C. 2002. Dietary isothiocyanates, glutathione Stransferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23: 2055-2061.
32. Shan, Y., Sun, C., Zhao, X., Wu, K., Cassidy, A. and Bao, Y. 2006. Effect of sulforaphane on cell growth, G0/G1 phase cell progression and apoptosis in human bladder cancer T24 cells. Int. J. Oncol. 29: 883-888.
33. Shonhof, I., Kläring, H. F., Krumbein, A., Clausen, W. and Schreiner, M. 2006. Effect of temperature increase under low radiation conditions on phytochemicals and ascorbic acid in greenhouse grown broccoli. Agric. Ecosyst. Environ. 119: 103-111.
34. Song, L. and Thornalley, P. J. 2007. Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables. Food Chem. Toxicol. 45: 216-224.
35. Toruner, G. A., Akyerli, C, Ucar, A., AkI, T., Atsu, N., Ozen, H., Tez, M., Cetinkaya M. and Ozcelik, T. 2001. Polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and bladder cancer susceptibility in the Turkish population. Arch. Toxicol. 75: 459-464.
36. Traka, M., Gasper, A. V., Melchini A., Bacon, J. R., Needs, P. W., Frost, V., Chantry, A., Jones, A. M. E, Ortori, C. A., Barrett, D. A., Ball, R. Y., Mills, R. D. and Mithen, R. F. 2008. Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS ONE 3: e2568
37. Velasco, P., Cartea, M. E., Gonzalez, C, Vilar, M. and Ordas, A. 2007. Factors affecting the glucosinolate content of kale (Brassica oleracea acephala Group). J. Agric. Food Chem. 55: 955-962.
38. Volden, J., Borge, G. I. A., Hansen, M., Wicklund, T. and Bengtsson, G. B. 2009. Processing (blanching, boiling, steaming) effects on the content of glucosinolates andantioxidant-related parameters in cauliflower (Brassica oleracea L. ssp. botrytis). Food Sci. Technol. 42: 63-73.
39. Wang, L. I., Giovannucci, E. L., Hunter, D., Neuberg, D., Su, L. and Christiani, D. C. 2004. Dietary intake of Cruciferous vegetables, Glutathione S-transferase (GST) polymorphisms and lung cancer risk in a Caucasian population. Cancer Causes Control 10: 977-985.
40. Zabala, M. D. T., Grant, M., Bones, A. M., Bennett, R., Yin, S. L., Kissen, R. and Rossiter, J. T. 2005. Characterisation of recombinant epithiospecifier protein and its over-expression in Arabidopsis thaliana. Phytochemistry 66: 859-867.
41. Zhao, B., Seow, A., Lee, A. J., Poh, W. T., The, M., Eng, P., Wang, Y. T., Tan, W. C, Yu, M. C. and Lee, H. P. 2001. Dietary isothiocyanates, glutathione S-transferase-M1, -T1 polymorphisms and lung cancer risk among Chinese woman in Singapore. Cancer Epidem. Biomarkers Prevent. 10: 1063-1067.
42. Zhao, F. J., Evans, E. J., Bilsborrow, P. E. and Syers, J. K. 1994. Influence of nitrogen and sulfur on the glucosinolate profile of rape-seed (Brassica napus L.). J. Sci. Food Agric. 64: 295-304.
43. Zickute, J., Strumylaite, L., Dregyal, L., Petrauskiene, J., Dudzevicius, J. and Strartilovas, E. 2005. Vegetables and fruits and risk of stomach cancer. Medicina (Kaunas, Lithiuania) 41: 733-740.