Ductal lesions in patients with chronic pancreatitis show K-ras mutations in a frequency similar to that in the normal pancreas and lack nuclear immunoreactivity for p53

Cancer

Volumn 88, Issue 11, 2000, Pages 2495-2504

  Lüttges, Jutta ^a   Diederichs, Anke ^a   Menke, Martin A O H ^a   Vogel, Ilka ^a   Kremer, Bernd ^a   Klöppel, Günter ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

Chronic pancreatitis; Ductal lesions; K ras mutation; P53 immunoreactivity

Indexed keywords

PROTEIN P53;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CHRONIC PANCREATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE MUTATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ONCOGENE K RAS; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; GENES, RAS; HUMANS; HYPERPLASIA; MALE; MIDDLE AGED; MUTATION; PANCREAS; PANCREATIC DUCTS; PANCREATITIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0343294326     PISSN: 0008543X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0142(20000601)88:11<2495::AID-CNCR10>3.0.CO;2-B     Document Type: Article

References (45)

1. Comfort MW, Steinberg AG. Pedigree of a family with hereditary chronic relapsing pancreatitis. Gastroenterology 1952;21:54-63.
2. DiMagno EP. Early diagnosis of chronic pancreatitis and pancreatic cancer. Med Clin North Am 1988;72:979-92.
3. Klöppel G, Bommer G, Rückert K, Seifert G. Intraductal proliferation in the pancreas and its relationship to human and experimental carcinogenesis. Virchows Arch A Pathol Anat 1980;387:221-33.
4. Volkholz H, Stolte M, Becker V. Epithelial dysplasias in chronic pancreatitis. Virchows Arch A Pathol Anat 1982;396: 331-49.
5. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, et al. Pancreatitis and the risk of pancreatic cancer. N Engl J Med 1993;328:1433-7.
6. Lowenfels AB, Maisonneuve P, DiMagno EP, Elitsur Y, Gates LK Jr., Perrault J, et al. Hereditary pancreatitis and the risk of pancreatic cancer. J Natl Cancer Inst 1997;89:442-6.
7. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988;53:549-54.
8. Hruban RH, van Mansfeld ADM, Offerhaus GJA, van Weering DHJ, Allison DC, Goodman SN, et al. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 1993;143: 545-54.
9. Redston MS, Caldas C, Seymour AB, Hruban RH, da Costa L, Yeo CJ, et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 1994;54:3025-33.
10. Ruggeri BA, Huang L, Berger D, Chang H, Klein-Szanto AJP, Goodrow T, et al. Molecular pathology of primary and metastatic ductal pancreatic lesions. Analyses of mutations and expression of the p53, mdm-2, and p21/waf-1 genes in sporadic and familial lesions. Cancer 1997;79:700-16.
11. Tada M, Omata M, Kawai S, Saisho H, Ohto M, Saiki RK, et al. Detection of ras gene mutations in pancreatic juice and peripheral blood of patients with pancreatic adenocarcinoma. Cancer Res 1993;53:2472-4.
12. Moskaluk CA, Hruban RH, Kern SE. p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 1997;57:2140-3.
13. Terhune PG, Phifer DM, Tosteson TD, Longnecker DS. K-ras mutation in focal proliferative lesions of human pancreas. Cancer Epidemiol Biomarkers Prev 1998;7:515-21.
14. van Laethem JL, Vertongen P, Devière J, Van Rampelbergh J, Rickaert F, Cremer M, et al. ERCP meets C-K-ras: towards an improved diagnosis of pancreatic cancer. Gastroenterology 1996;110:311-3.
15. Iguchi H, Sugano K, Fukayama N, Ohkura H, Sadamoto K, Ohkoshi K, et al. Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer. Gastroenterology 1996;110:221-6.
16. Furuya N, Kawa S, Akamatsu T, Furihata K. Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice. Gastroenterology 1997;113:593-8.
17. Tabata T, Fujimoro T, Maeda S, Yamamoto M, Saitoh Y. The role of ras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis. Int J Pancreatol 1993;14: 237-44.
18. Tada M, Ohashi M, Shiratori Y, Okudaira T, Komatsu Y, Kawabe T, et al. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease. Gastroenterology 1996;110:227-31.
19. Lüttges J, Schlehe B, Menke MAOH, Vogel I, Henne-Bruns D, Klöppel G. The K-ras mutation pattern in pancreatic ductal adenocarcinoma is usually identical to that in associated normal, hyperplastic and metaplastic duct epithelium. Cancer 1999;85:1703-10.
20. Rivera JA, Rall CJN, Graeme-Cook F, Fernández-del Castillo C, Shu P, Lakey N, et al. Analysis of K-ras oncogene mutations in chronic pancreatitis with ductal hyperplasia. Surgery 1997;121:42-9.
21. Iwao T, Hanada K, Tsuchida A, Hirata M, Eguchi N, Kajiyama G. The establishment of a preoperative diagnosis of pancreatic carcinoma using cell specimens from pancreatic duct brushing with special attention to p53 mutations. Cancer 1998;82:1487-94.
22. Klöppel G, Solcia E, Longnecker DS, Capella C, Sobin LH. Histological typing of tumours of the exocrine pancreas. 2nd ed. WHO International histological classification of tumours. Berlin: Springer, 1996:
23. Klöppel G, Maillet B. Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata. Pancreas 1991;6:266-74.
24. Kreipe H, Wacker HH, Heidebrecht HJ, Haas K, Hauberg M, Tiemann M, et al. Determination of the growth fraction in non-Hodgkin's lymphoma by monoclonal antibody Ki-S5 directed against a formalin-resistant epitope of the Ki-67 antigen. Am J Pathol 1993;142:1689-94.
25. Menke MAOH, Reinecke-Lüthge A, Möllmann B, Kellner A, Lüttges J, Klöppel G, Detection of K-ras point mutations in the pancreas by constant denaturing gel electrophoresis using the DCode system. BioRadiations 1998;102:30-1.
26. Becker V. Carcinoma of the pancreas and chronic pancreatitis - a possible relationship. Acta Hepatogastroenterol 1978;25:257-9.
27. Müller J, Gansauge S, Schmid R, Gansauge F, Adler G, Beger HG. p53 aber nicht K-ras Mutationen können in der chronischen Pankreatitis gefunden werden (p53 but not K-ras mutations are found in chronic pancreatitis). Langenbecks Arch Chir 1997;I(Forumband 1997):715-8.
28. Cylwik B, Nowak HF, Puchalski Z, Barczyk J. Epithelial anomalies in chronic pancreatitis as a risk factor of pancreatic cancer. Hepatogastroenterology 1998;45:528-32.
29. Balagué C, Audié JP, Porchet N, Real FX. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues. Gastroenterology 1995;109:953-64.
30. Terada T, Ohta T, Kitamura Y, Ashida K, Matsunaga Y, Kato M. Endocrine cells in intraductal papillary-mucinous neoplasms of the pancreas. A histochemical and immunohistochemical study. Virchows Arch 1997;431:31-6.
31. Yonezawa S, Sueyoshi K, Nomoto M, Kitamura H, Nagata K, Arimura Y, et al. MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: its close relationship with prognosis of the patients. Hum Pathol 1997;28:344-52.
32. Bätge B, Bosslet K, Sedlacek HH, Kern HF, Klöppel G. Monoclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and nonneoplastic duct lesions as well as nonduct type neoplasias. Virchows Arch A Pathol Anat 1986;408:361-74.
33. Klöppel G, Lohse T, Bosslet K, Rückert K. Ductal adenocarcinoma of the head of the pancreas: incidence of tumor involvement beyond the Whipple resection line. Histological and immunocytochemical analysis of 37 total pancreatectomy specimens. Pancreas 1987;2:170-5.
34. Ishimaru S, Itoh M, Hanada K, Tsuchida A, Iwao T, Kajiyama G. Immunocytochemical detection of p53 protein from pancreatic duct brushings in patients with pancreatic carcinoma. Cancer 1996;77:2233-9.
35. van Es JM, Polak MM, van den Berg FM, Ramsoekh TB, Craanen ME, Hruban RH, et al. Molecular markers for diagnostic cytology of neoplasms in the head of the pancreas: mutation of K-ras and overexpression of the p53 protein product. J Clin Pathol 1995;48:218-22.
36. Sturm PD, Hruban RH, Ramsoekh TB, Norduyn LA, Tytgat GN, Gouma DJ, et al. The potential diagnostic use of K-ras codon 12 and p53 alterations in brush cytology from the pancreatic head region. J Pathol 1998;186:247-53.
37. Maacke H, Kessler A, Schmiegel W, Roeder C, Vogel I, Deppert W, et al. Overexpression of p53 protein during pancreatitis. Br J Cancer 1997;75:1501-4.
38. Shaw PH. The role of p53 in cell cycle regulation. Pathol Res Pract 1996;192:669-75.
39. Yanagisawa A, Ohtake K, Ohashi K, Hori M, Kitagawa T, Sugano H, et al. Frequent c-Ki-ros oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res 1993;53:953-6.
40. Hsiang D, Friess H, Büchler MW, Ebert M, Butler J, Korc M. Absence of K-ras mutations in the pancreatic parenchyma of patients with chronic pancreatitis. Am J Surg 1997;174: 242-6.
41. Orth M, Gansauge F, Gansauge S, Beger HG, Adler G, Schmid RM. K-ras mutations at codon 12 are rare events in chronic pancreatitis. Digestion 1998;59:120-4.
42. Lüttges J, Reinecke-Lüthge A, Möllmann B, Menke MAOH, Clemens A, Klimpfinger M, et al. Duct changes and K-ras mutations in the disease-free pancreas: analysis of type, age relation and spatial distribution. Virchows Arch 1999;435:461-8.
43. Berger DH, Chang H, Wood M, Huang L, Heath CW, Lehman T, et al. Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status. Cancer 1999;85:326-32.
44. Berthélemy P, Bouisson M, Escourrou J, Vaysse N, Rumeau JL, Pradayrol L. Identification of K-ras mutations in pancreatic juice in the early diagnosis of pancreatic cancer. Ann Intern Med 1995;123:188-91.
45. Wilentz RE, Geradts J, Maynard R, Offerhaus GJ, Kang M, Goggins M, et al. Inactivation of the p16 (INK4A) tumor-suppressor gene in pancreatic duct lesions: loss of intranuclear expression. Cancer Res 1998;58:4740-4.