Phosphorylation-dependent autoinhibition of myosin light chain phosphatase accounts for Ca2+ sensitization force of smooth muscle contraction

Journal of Biological Chemistry

Volumn 284, Issue 32, 2009, Pages 21569-21579

  Khromov, Alexander ^a   Choudhury, Nandini ^a   Stevenson, Andra S ^a   Somiyo, Avril V ^a   Eto, Masumi ^b,c,d  

^a UNIVERSITY OF VIRGINIA   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; AUTOINHIBITION; CATALYTIC SUBUNITS; GLUTATHIONE-S-TRANSFERASE; MICROCYSTINS; MYOSIN LIGHT CHAIN PHOSPHATASE; MYOSIN LIGHT CHAIN PHOSPHATASE ( MLCP); MYOSIN PHOSPHATASE; PHOSPHORYLATION SITES; PROTEIN KINASE; REGULATORY SUBUNITS; SMOOTH MUSCLES;

CALCIUM; LAWS AND LEGISLATION; LIGHT TRANSMISSION; MUSCLE; SHRINKAGE; SYSTEM THEORY;

PHOSPHORYLATION;

ALANINE; BETA ESCIN; CALCIUM ION; ESCIN; GLUTATHIONE TRANSFERASE; MYOSIN LIGHT CHAIN PHOSPHATASE; MYOSIN LIGHT CHAIN PHOSPHATASE TARGETING SUBUNIT 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DEPHOSPHORYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; IC 50; ILEUM; MUSCLE FORCE; MUSCLE RELAXATION; MUTATION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SMOOTH MUSCLE CONTRACTION;

ALANINE; CALCIUM; CALCIUM SIGNALING; CATALYTIC DOMAIN; ESCIN; GLUTATHIONE TRANSFERASE; HUMANS; INHIBITORY CONCENTRATION 50; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUTATION; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; THREONINE;

EID: 69249105976     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.019729     Document Type: Article

References (69)

1. Somlyo, A. P., and Somlyo, A. V. (2003) Physiol. Rev. 83, 1325-1358
2. Rembold, C. M. (1992) Hypertension 20, 129-137
3. Bradley, A. B., and Morgan, K. G. (1987) J. Physiol. 385, 437-448
4. Himpens, B., and Casteels, R. (1990) Pflugers Arch. 416, 28-35
5. Himpens, B., Kitazawa, T., and Somlyo, A. P. (1990) Pflugers Arch. 417, 21-28
6. Guo, Z., Su, W., Ma, Z., Smith, G. M., and Gong, M. C. (2003) J. Biol. Chem. 278, 1856-1863
7. Wang, Y., Yoshioka, K., Azam, M. A., Takuwa, N., Sakurada, S., Kayaba, Y., Sugimoto, N., Inoki, I., Kimura, T., Kuwaki, T., and Takuwa, Y. (2006) Biochem. J. 394, 581-592
8. Sakurada, S., Takuwa, N., Sugimoto, N., Wang, Y., Seto, M., Sasaki, Y., and Takuwa, Y. (2003) Circ. Res. 93, 548-556
9. Himpens, B., Matthijs, G., and Somlyo, A. P. (1989) J. Physiol. 413, 489-503
10. Kitazawa, T., and Somlyo, A. P. (1990) Biochem. Biophys. Res. Commun. 172, 1291-1297
11. Wu, J., Kleiner, U., and Brautigan, D. L. (1996) Biochemistry 35, 13858-13864
12. Lee, M. R., Li, L., and Kitazawa, T. (1997) J. Biol. Chem. 272, 5063-5068
13. Sausbier, M., Schubert, R., Voigt, V., Hirneiss, C., Pfeifer, A., Korth, M., Kleppisch, T., Ruth, P., and Hofmann, F. (2000) Circ. Res. 87, 825-830
14. Etter, E. F., Eto, M., Wardle, R. L., Brautigan, D. L., and Murphy, R. A. (2001) J. Biol. Chem. 276, 34681-34685
15. Bonnevier, J., and Arner, A. (2004) J. Biol. Chem. 279, 28998-29003
16. Hartshorne, D. J., Ito, M., and Erdödi, F. (2004) J. Biol. Chem. 279, 37211-37214
17. Terrak, M., Kerff, F., Langsetmo, K., Tao, T., and Dominguez, R. (2004) Nature 429, 780-784
18. Velasco, G., Armstrong, C., Morrice, N., Frame, S., and Cohen, P. (2002) FEBS Lett. 527, 101-104
19. Fukata, Y., Kimura, K., Oshiro, N., Saya, H., Matsuura, Y., Kaibuchi, K. (1998) J. Cell Biol. 141, 409-418
20. Dirksen, W. P., Vladic, F., and Fisher, S. A. (2000) Am. J. Physiol. Cell Physiol. 278, C589-600
21. Richards, C. T., Ogut, O., and Brozovich, F. V. (2002) J. Biol. Chem. 277, 4422-4427
22. Khatri, J. J., Joyce, K. M., Brozovich, F. V., and Fisher, S. A. (2001) J. Biol. Chem. 276, 37250-37257
23. Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, M., Lincoln, T. M., and Mendelsohn, M. E. (1999) Science 286, 1583-1587
24. Huang, Q. Q., Fisher, S. A., and Brozovich, F. V. (2004) J. Biol. Chem. 279, 597-603
25. Given, A. M., Ogut, O., and Brozovich, F. V. (2007) Am. J. Physiol. Cell Physiol. 292, C432-439
26. Surks, H. K., Richards, C. T., and Mendelsohn, M. E. (2003) J. Biol. Chem. 278, 51484-51493
27. Wooldridge, A. A., MacDonald, J. A., Erdodi, F., Ma, C., Borman, M. A., Hartshorne, D. J., and Haystead, T. A. (2004) J. Biol. Chem. 279, 34496-34504
28. Kawano, Y., Yukata, Y., Oshiro, N., Amano, M., Nakamura, T., Ito, M., Matsumura, F., Inagaki, M., and Kaibuchi, K. (1999) J. Cell Biol. 147, 1023-1138
29. Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., and Kaibuchi, K. (1996) Science 273, 245-248
30. Murányi, A., MacDonald, J. A., Deng, J. T., Wilson, D. P., Haystead, T. A., Walsh, M. P., Erdodi, F., Kiss, E., Wu, Y., and Hartshorne, D. J. (2002) Biochem. J. 366, 211-216
31. MacDonald, J. A., Borman, M. A., Murányi, A., Somlyo, A. V., Hartshorne, D. J., and Haystead, T. A. J. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 2419-2424
32. Takizawa, N., Koga, Y., and Ikebe, M. (2002) Biochem. Biophys. Res. Commun. 297, 773-778
33. Eto, M., Karginov, A., and Brautigan, D. L. (1999) Biochemistry 38, 16952-16957
34. Koyama, M., Ito, M., Feng, J., Seko, T., Shiraki, K., Takase, K., Hartshorne, D. J., and Nakano, T. (2000) FEBS Lett. 475, 197-200
35. Dimopoulos, G. J., Semba, S., Kitazawa, K., Eto, M., and Kitazawa, T. (2007) Circ. Res. 100, 121-129
36. Kitazawa, T., Eto, M., Woodsome, T. P., and Khalequzzaman, M. (2003) J. Physiol. 546, 879-889
37. Seko, T., Ito, M., Kureishi, Y., Okamoto, R., Moriki, N.. Onishi, K., Isaka, N., Hartshorne, D. J., and Nakano, T. (2003) Circ. Res. 92, 411-418
38. Hilgers, R. H., Todd, J., Jr., and Webb, R. C. (2007) J. Hypertens 25, 1687-1697
39. Guilluy, C., Sauzeau, V., Rolli-Derkinderen, M., Guérin, P., Sagan, C., Pacaud, P., and Loirand, G. (2005) Br. J. Pharmacol. 146, 1010-1018
40. Nakamura, K., Koga, Y., Sakai, H., Homma, K., and Ikebe, M. (2007) Circ. Res. 101, 712-722
41. Neppl, R. L., Lubomirov, L. T., Momotani, K., Pfitzer, G., Eto, M., and Somlyo, A. V. (2009) J. Biol. Chem. 284, 6348-6360
42. Choudhury, N., Khromov, A. S., Somlyo, A. P., and Somlyo, A. V. (2004) J. Muscle Res. Cell. Motil. 25, 657-665
43. Ichikawa. K., Ito, M., and Hartshorne, D. J. (1996) J. Biol. Chem. 271, 4733-4740
44. Shin, H. M., Je, H. D., Gallant, C., Tao, T. C., Hartshorne, D. J., Ito, M., and Morgan, K. G. (2002) Circ. Res. 90, 546-553
45. Bolz, S. S., Vogel, L., Sollinger, D., Derwand, R., de Wit, C., Loirand, G., and Pohl, U. (2003) Circulation 107, 3081-3087
46. Murányi, A., Derkach, D., Erdodi, F., Kiss, A., Ito, M., and Hartshorne, D. J. (2005) FEBS Lett. 579, 6611-6615
47. Tan, I., Ng, C. H., Lim, L., and Leung, T. (2001) J. Biol. Chem. 276, 21209-21216
48. Eto, M., Ohmori, T., Suzuki, M., Furuya, K., and Morita, F. (1995) J. Biochem. 118, 1104-1107
49. Martin, B. L., Shriner, C., and Brautigan, D. L. (1994) Protein Expression Purif. 5, 211-217
50. Eto, M., Leach, C., Tountas, N. A., and Brautigan, D. L. (2003) Methods Enzymol. 366, 243-260
51. Matsuzawa, F., Aikawa, S. I., Ohki, S. Y., and Eto, M. (2005) J. Biochem. 137, 633-641
52. Kitazawa, T., Kobayashi, S., Horiuti, K., Somlyo, A. V., and Somlyo, A. P. (1989) J. Biol. Chem. 264, 5339-5342
53. Eto, M., Senba, S., Morita, F., and Yazawa, M. (1997) FEBS Lett. 410, 356-360
54. Ishihara, H., Martin, B. L., Brautigan, D. L., Karaki, H., Ozaki, H., Kato, Y., Fusetani, N., Watabe, S., Hashimoto, K, and Uemura, D. (1989). Biochem. Biophys. Res. Commun. 159, 871-877
55. Goldberg, J., Huang, H. B., Kwon, Y. G., Greengard, P., Nairn, A. C., and Kuriyan, J. (1995) Nature 376, 745-753
56. Eto, M., Kirkbride, J. A., and Brautigan, D. L. (2005) Cell Motil, Cytoskeleton 62, 100-109
57. Gong, M. C., Cohen, P., Kitazawa, T., Ikebe, M., Masuo, M., Somlyo, A. P., and Somlyo, A. V. (1992) J. Biol. Chem. 267, 14662-14668
58. Woodsome, T. P., Eto, M., Everett, A., Brautigan, D. L., and Kitazawa, T. (2001) J. Physiol. 535, 553-564
59. Eto, M., Kitazawa, T., Matsuzawa, F., Aikawa, S., Kirkbride, J. A., Isozumi, N., Nishimura, Y., Brautigan, D. L., and Ohki, S. Y. (2007) Structure 15, 1591-1602
60. Klee, C. B., Ren, H., and Wang, X. (1998) J. Biol. Chem. 273, 13367-13370
61. Stewart, A. A., Ingebritsen, T. S., and Cohen, P. (1983) Eur. J. Biochem. 132, 289-295
62. Perrino, B. A., Ng, L. Y., and Soderling, T. R. (1995) J. Biol. Chem. 270, 340-346
63. Kissinger, C. R., Parge, H. E., Knighton, D. R., Lewis, C. T., Pelletier, L. A., Tempczyk, A., Kalish, V. J., Tucker, K. D., Showalter, R. E., Moomaw, E. W., Louis, N. G., Habuka, N., Chen, X. M., Maldonado, F., Barker, J. E., Bacquet, R., and Villafranca, J. E. (1995) Nature 378, 641-644
64. Wang, H., Dui Y., Xiang, B., Lin, W., Li, X., and Wei, Q. (2008) Biochemistry 47, 4461-4468
65. Wu, X., Haystead, T. A., Nakamoto, R. K., Somlyo, A. V., and Sornlyo, A. P. (1998) J. Biol. Chem. 273, 11362-11369
66. Sauzeau, V., Le Jeune, H., Cario-Toumaniantz, C., Smolenski, A., Lohmann, S. M., Bertoglio, J., Chardin, P., Pacaud, P., and Loirand, G. (2000) J. Biol. Chem. 275, 21722-21729
67. Totsukawa, G., Yamakita, Y., Yamashiro, S., Hosoya, H., Hartshorne, D. J., and Matsumura, F. (1999) J. Cell Biol. 144, 735-744
68. Ohki, S., Eto, M., Shimizu, M., Takada, R., Brautigan, D. L., and Kainosho, M. (2003) J. Mol. Biol. 326, 1539-1547
69. Eto, M., Kitazawa, T., and Brautigan, D. L. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 888-8893