Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate

Toxicology in Vitro

Volumn 22, Issue 4, 2008, Pages 1107-1114

  Verstraelen, S ^a   Wens, B ^a   Hooyberghs, J ^a   Nelissen, I ^a   Witters, H ^a   Schoeters, G ^a   Cauwenberge, P Van ^b   Heuvel, R Van Den ^a  

^a FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Hexamethylene diisocyanate; Macrophages; Respiratory allergy; Transcriptomics

Indexed keywords

CYTOKINE; HEXAMETHYLENE DIISOCYANATE; OLIGONUCLEOTIDE; TRANSCRIPTOME;

ALLERGIC ASTHMA; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DETOXIFICATION; DISEASE MARKER; DNA MICROARRAY; EXPOSURE; GENE EXPRESSION PROFILING; GENETIC MARKER; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS MACROPHAGE; LUNG TOXICITY; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; RESPIRATORY TRACT ALLERGY;

AIR POLLUTANTS, OCCUPATIONAL; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; CELLS, CULTURED; CYANATES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LEUKEMIA, MONOCYTIC, ACUTE; MACROPHAGES; OCCUPATIONAL EXPOSURE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TIME FACTORS;

EID: 41949139654     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.02.015     Document Type: Article

References (48)

1. Auwerx J. The human leukemia cell line, THP-1: a multifacetted model for the study of monocyte-macrophage differentiation. Experientia 47 (1991) 22-31
2. Baur X., Marek W., Ammon J., Czuppon A.B., Marczynski B., Raulf-Heimsoth M., Roemmelt H., and Fruhmann G. Respiratory and other hazards of isocyanates. International Archives of Occupational and Environmental Health 66 (1994) 141-152
3. Bernstein D.I., Cartier A., Cote J., Malo J.L., Boulet L.P., Wanner M., Milot J., L'Archeveque J., Trudeau C., and Lummus Z. Diisocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficiency than specific antibodies for identification of diisocyanate asthma. American Journal of Respiratory and Critical Care Medicine 166 (2002) 445-450
4. Carter E.P., Garat C., and Imamura M. Continual emerging roles of HO-1: protection against airway inflammation. American Journal of Physiology - Lung Cellular and Molecular Physiology 287 (2004) L24-L25
5. Curran A.D., and Fishwick D. Occupational asthma: research, change and the 30% target. Annals of Occupational Hygiene 47 (2003) 433-436
6. Day B.W., Jin R., Basalyga D.M., Kramarik J.A., and Karol M.H. Formation, solvolysis, and transcarbamoylation reactions of bis(S-glutathionyl) adducts of 2,4- and 2,6-diisocyanatotoluene. Chemical Research in Toxicology 10 (1997) 424-431
7. Deschamps F., Prevost A., Lavaud F., and Kochman S. Mechanisms of occupational asthma induced by isocyanates. Annals of Occupatinal Hygiene 42 (1998) 33-36
8. Donnelly L.E., and Barnes P.J. Expression of heme oxygenase in human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology 24 (2001) 295-303
9. Harju T., Soini Y., Paakko R., and Kinnula V.L. Up-regulation of heme oxygenase-I in alveolar macrophages of newly diagnosed asthmatics. Respiratory Medicine 96 (2002) 418-423
10. Herrick C.A., Xu L., Wisnewski A.V., Das J., Redlich C.A., and Bottomly K. A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge. Journal of Allergy and Clinical Immunology 109 (2002) 873
11. Hirota M., and Moro O. MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicology in Vitro 20 (2006) 736-742
12. Hulette B.C., Ryan C.A., Gildea L.A., and Gerberick G.F. Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Toxicology and Applied Pharmacology 209 (2005) 159-166
13. Jacobs J.J., Lehe C.L., Hasegawa H., Elliott G.R., and Das P.K. Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration. Experimental Dermatology 15 (2006) 432-440
14. Jones M.G., Floyd A., Nouri-Aria K.T., Jacobson M.R., Durham S.R., Taylor A.N., and Cullinan P. Is occupational asthma to diisocyanates a non-IgE-mediated disease?. Journal of Allergy and Clinical Immunology 117 (2006) 663
15. Keyse S.M., and Tyrrell R.M. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proceedings of the National Academy of Sciences 86 (1989) 99-103
16. Lange R.W., Day B.W., Lemus R., Tyurin V.A., Kagan V.E., and Karol M.H. Intracellular S-glutathionyl adducts in murine lung and human bronchoepithelial cells after exposure to diisocyanatotoluene. Chemical Research in Toxicology 12 (1999) 931-936
17. Lange R.W., Lantz R.C., Stolz D.B., Watkins S.C., Sundareshan P., Lemus R., and Karol M.H. Toluene diisocyanate colocalizes with tubulin on cilia of differentiated human airway epithelial cells. Toxicological Sciences 50 (1999) 64-71
18. Lantz R.C., Lemus R., Lange R.W., and Karol M.H. Rapid reduction of intracellular glutathione in human bronchial epithelial cells exposed to occupational levels of toluene diisocyanate. Toxicological Sciences 60 (2001) 348-355
19. Lee C.T., Ylostalo J., Friedman M., and Hoyle G.W. Gene expression profiling in mouse lung following polymeric hexamethylene diisocyanate exposure. Toxicology and Applied Pharmacology 205 (2005) 53-64
20. Lee P.J., Alam J., Wiegand G.W., and Choi A.M. Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proceedings of the National Academy of Sciences 93 (1996) 10393-10398
21. Lemus R., Lukinskeine L., Bier M.E., Wisnewski A.V., Redlich C.A., and Karol M.H. Development of immunoassays for biomonitoring of hexamethylene diisocyanate exposure. Environmental Health Perspectives 109 (2001) 1103-1108
22. Lummus Z.L., Alam R., Bernstein J.A., and Bernstein D.I. Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-[α] by peripheral mononuclear cells of workers with occupational asthma. Journal of Allergy and Clinical Immunology 102 (1998) 265
23. Marcet B., Horckmans M., Libert F., Hassid S., Boeynaems J.M., and Communi D. Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells. Journal of Cellular Physiology 211 (2007) 716-727
24. Millstein J., Conti D.V., Gilliland F.D., and Gauderman W.J. A testing framework for identifying susceptibility genes in the presence of epistasis. American Journal of Human Genetics 78 (2006) 15-27
25. Morimoto R.I. Cells in stress: transcriptional activation of heat shock genes. Science 259 (1993) 1409-1410
26. Okayama Y., and Kawakami T. Development, migration, and survival of mast cells. Immunologic Research 34 (2006) 97-115
27. Pauluhn J., and Mohr U. Inhalation toxicity of 1,6-hexamethylene diisocyanate homopolymers (HDI-IC and HDI-BT): results of subacute and subchronic repeated inhalation exposure studies. Inhalation Toxicology 13 (2001) 513-532
28. Peltoniemi M., Kaarteenaho-Wiik R., Saily M., Sormunen R., Paakko P., Holmgren A., Soini Y., and Kinnula V.L. Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Human Pathology 35 (2004) 1000-1007
29. Piirila P.L., Nordman H., Keskinen H.M., Luukkonen R., Salo S.P., Tuomi T.O., and Tuppurainen M. Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma. American Journal of Respiratory and Critical Care Medicine 162 (2000) 516-522
30. Plitnick L.M., Loveless S.E., Ladics G.S., Holsapple M.P., Smialowicz R.J., Woolhiser M.R., Anderson P.K., Smith C., and Selgrade M.J. Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. Toxicology 207 (2005) 487-499
31. Redlich C.A., and Karol M.H. Diisocyanate asthma: clinical aspects and immunopathogenesis. International Immunopharmacology 2 (2002) 213-224
32. Redlich C.A., Wisnewski A.V., and Gordon T. Mouse models of diisocyanate asthma. American Journal of Respiratory Cell and Molecular Biology 27 (2002) 385-390
33. Rizzardini M., Terao M., Falciani F., and Cantoni L. Cytokine induction of haem oxygenase mRNA in mouse liver. Interleukin 1 transcriptionally activates the haem oxygenase gene. Biochemical Journal 290 Pt 2 (1993) 343-347
34. Schoeters, E., Verheyen, G.R., Nelissen, I., Van Rompay, A.R., Hooyberghs, J., Van Den Heuvel, R.L., Witters, H., Schoeters, G.E., Van Tendeloo, V.F., Berneman, Z.N., 2007. Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Molecular Immunology.
35. Smyth G.K., and Speed T. Normalization of cDNA microarray data. Methods 31 (2003) 265-273
36. Storey J.D. A direct approach to false discovery rates. Journal of Royal Statistical Society B 64 (2002) 479-498
37. Tee R.D., Cullinan P., Welch J., Burge P.S., and Newman-Taylor A.J. Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. Journal of Allergy and Clinical Immunology 101 (1998) 709
38. Tsuchiya S., Yamabe M., Yamaguchi Y., Kobayashi Y., Konno T., and Tada K. Establishment and characterization of a human acute monocytic leukemia cell line (THP-1). International Journal of Cancer 26 (1980) 171-176
39. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proceedings of the National Academy of Sciences 98 (2001) 5116-5121
40. Vignola A.M., Chanez P., Polla B.S., Vic P., Godard P., and Bousquet J. Increased expression of heat shock protein 70 on airway cells in asthma and chronic bronchitis. American Journal of Respiratory Cell and Molecular Biology 13 (1995) 683-691
41. Viksman M.Y., Bochner B.S., Peebles R.S., Schleimer R.P., and Liu M.C. Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge. Clinical Immunology 104 (2002) 77-85
42. Viksman M.Y., Liu M.C., Bickel C.A., Schleimer R.P., and Bochner B.S. Phenotypic analysis of alveolar macrophages and monocytes in allergic airway inflammation. I. Evidence for activation of alveolar macrophages, but not peripheral blood monocytes, in subjects with allergic rhinitis and asthma. American Journal of Respiratory and Critical Care Medicine 155 (1997) 858-863
43. Wisnewski A.V., Herrick C.A., Liu Q., Chen L., Bottomly K., and Redlich C.A. Human [γ]/[δ] T-cell proliferation and IFN-[γ] production induced by hexamethylene diisocyanate. Journal of Allergy and Clinical Immunology 112 (2003) 538
44. Wisnewski A.V., Lemus R., Karol M.H., and Redlich C.A. Isocyanate-conjugated human lung epithelial cell proteins: a link between exposure and asthma?. Journal of Allergy and Clinical Immunology 104 (1999) 341-347
45. Wisnewski A.V., Liu Q., Miller J.J., Magoski N., and Redlich C.A. Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies. Environmental Health Perspectives 110 (2002) 901-907
46. Wisnewski A.V., Srivastava R., Herick C., Xu L., Lemus R., Cain H., Magoski N.M., Karol M.H., Bottomly K., and Redlich C.A. Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo. American Journal of Respiratory and Critical Care Medicine 162 (2000) 2330-2336
47. Xia Z.W., Zhong W.W., Xu L.Q., Sun J.L., Shen Q.X., Wang J.G., Shao J., Li Y.Z., and Yu S.C. Heme oxygenase-1-mediated CD4 + CD25 high regulatory T cells suppress allergic airway inflammation. Journal of Immunology 177 (2006) 5936-5945
48. Youker, R.T., 2005. The role of molecular chaperones in the ER associated degradation of the cystic fibrosis transmembrane conductance regulator in the budding yeast S. cerevisiae. School of Arts and Sciences, University of Pittsburgh.