Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II

Biochemistry

Volumn 48, Issue 33, 2009, Pages 7996-8005

  Maupin, C Mark ^a   Zheng, Jiayin ^b   Tu, Chingkuang ^b   McKenna, Robert ^b   Silverman, David N ^b   Voth, Gregory A ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; DEUTERIUM CONTENT; HUMAN CARBONIC ANHYDRASE II; KINETIC ISOTOPE EFFECTS; MOLECULAR DYNAMICS SIMULATIONS; ORDERED WATER; OUTWARD ORIENTATION; OVERALL RATE; PROTON-TRANSFER MECHANISM; RATE LIMITING; SIMULATION APPROACH; SITE-SPECIFIC; WATER CLUSTER; WATER STRUCTURE; WILD TYPES;

CLUSTER ANALYSIS; DEHYDRATION; DEUTERIUM; DEWATERING; HYDRATION; MOLECULAR DYNAMICS; MOLECULAR ORIENTATION; PHOTOTRANSISTORS; PLATINUM COMPOUNDS; PROTON TRANSFER; X RAY CRYSTALLOGRAPHY;

WATER ANALYSIS;

ASPARAGINE; CARBONATE DEHYDRATASE II; DEUTERIUM; HISTIDINE; WATER;

ARTICLE; DEHYDRATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; GENE MUTATION; HYDRATION; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTON TRANSPORT; SIMULATION;

ASPARAGINE; CARBONIC ANHYDRASE II; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME STABILITY; HISTIDINE; HUMANS; KINETICS; LEUCINE; MUTAGENESIS, SITE-DIRECTED; PROTON-MOTIVE FORCE; THERMODYNAMICS; WATER;

EID: 69049097266     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi901037u     Document Type: Article

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