Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II

Biochemistry

Volumn 47, Issue 46, 2008, Pages 12028-12036

  Zheng, Jiayin ^a   Avvaru, Balendu Sankara ^a   Tu, Chingkuang ^a   McKenna, Robert ^a   Silverman, David N ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL ORIENTATION; CRYSTALLOGRAPHY; HYDROGEN; HYDROPHILICITY; MINERALOGY; PROTONS; SELF ASSEMBLY; SOLVENTS; X RAY CRYSTALLOGRAPHY; ZINC;

ACTIVE SITES; BOUND SOLVENTS; CARBONIC ANHYDRASE; HUMAN CARBONIC ANHYDRASE II; HYDROPHILIC RESIDUES; MAXIMAL VELOCITIES; ORDERED WATERS; OUTWARD ORIENTATIONS; PROTON DONORS; SIDE CHAINS; WATER STRUCTURES; WILD TYPES; X-RAY CRYSTALLOGRAPHIES; ZINC METALLOENZYME;

PROTON TRANSFER;

CARBONATE DEHYDRATASE II; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME STRUCTURE; HYDRATION; PRIORITY JOURNAL; PROTON TRANSPORT; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; CARBON DIOXIDE; CARBONIC ANHYDRASE II; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PROTEIN STRUCTURE, TERTIARY; PROTONS; WATER;

EID: 56249123954     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801473w     Document Type: Article

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