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Volumn 34, Issue 10, 2009, Pages 1738-1747

Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids

Author keywords

Flufenamic acid; Glutamate transporters; Glycine transporters; Mefenamic acid; Niflumic acid

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER; FLUFENAMIC ACID; GLUTAMATE TRANSPORTER; GLYCINE TRANSPORTER; MEFENAMIC ACID; NIFLUMIC ACID;

EID: 69049087651     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-009-9983-y     Document Type: Article
Times cited : (10)

References (44)
  • 1
    • 0026548697 scopus 로고
    • Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation
    • J Lerma R Martin del Rio 1992 Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation Mol Pharmacol 41 217 222
    • (1992) Mol Pharmacol , vol.41 , pp. 217-222
    • Lerma, J.1    Martin Del Rio, R.2
  • 5
    • 0025372566 scopus 로고
    • Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas
    • 10.1016/0014-5793(90)80977-Q
    • H Gogelein D Dahlem HC Englert HJ Lang 1990 Flufenamic acid, mefenamic acid and niflumic acid inhibit single nonselective cation channels in the rat exocrine pancreas FEBS Lett 268 79 82 10.1016/0014-5793(90)80977-Q
    • (1990) FEBS Lett , vol.268 , pp. 79-82
    • Gogelein, H.1    Dahlem, D.2    Englert, H.C.3    Lang, H.J.4
  • 6
    • 0028308919 scopus 로고
    • Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein
    • RC Hogg Q Wang WA Large 1994 Action of niflumic acid on evoked and spontaneous calcium-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein Br J Pharmacol 112 977 984
    • (1994) Br J Pharmacol , vol.112 , pp. 977-984
    • Hogg, R.C.1    Wang, Q.2    Large, W.A.3
  • 7
    • 0032810212 scopus 로고    scopus 로고
    • + channel, by meclofenamic acid
    • 10.1016/S0014-2999(99)00485-9
    • + channel, by meclofenamic acid Eur J Pharmacol 378 349 356 10.1016/S0014-2999(99)00485-9
    • (1999) Eur J Pharmacol , vol.378 , pp. 349-356
    • Lee, Y.T.1    Wang, Q.2
  • 9
    • 0037064306 scopus 로고    scopus 로고
    • Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes
    • 10.1016/S0014-2999(02)02330-0
    • AP Malykhina F Shoeb HI Akbarali 2002 Fenamate-induced enhancement of heterologously expressed HERG currents in Xenopus oocytes Eur J Pharmacol 452 269 277 10.1016/S0014-2999(02)02330-0
    • (2002) Eur J Pharmacol , vol.452 , pp. 269-277
    • Malykhina, A.P.1    Shoeb, F.2    Akbarali, H.I.3
  • 11
    • 0035395177 scopus 로고    scopus 로고
    • Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4
    • 10.1111/j.1469-7793.2001.00159.x
    • MV Poulsen RJ Vandenberg 2001 Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4 J Physiol 534 159 167 10.1111/j.1469-7793.2001.00159.x
    • (2001) J Physiol , vol.534 , pp. 159-167
    • Poulsen, M.V.1    Vandenberg, R.J.2
  • 12
    • 33644664236 scopus 로고    scopus 로고
    • Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4
    • 10.1038/355
    • WA Fairman MS Sonders GH Murdoch SG Amara 1998 Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4 Nat Neurosci 1 105 113 10.1038/355
    • (1998) Nat Neurosci , vol.1 , pp. 105-113
    • Fairman, W.A.1    Sonders, M.S.2    Murdoch, G.H.3    Amara, S.G.4
  • 13
    • 0028911077 scopus 로고
    • Differential modulation of human glutamate transporter subtypes by arachidonic acid
    • 10.1074/jbc.270.12.6433
    • N Zerangue JL Arriza SG Amara MP Kavanaugh 1995 Differential modulation of human glutamate transporter subtypes by arachidonic acid J Biol Chem 270 6433 6435 10.1074/jbc.270.12.6433
    • (1995) J Biol Chem , vol.270 , pp. 6433-6435
    • Zerangue, N.1    Arriza, J.L.2    Amara, S.G.3    Kavanaugh, M.P.4
  • 14
    • 0024554279 scopus 로고
    • Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid
    • 10.1016/0753-3322(89)90140-6
    • B Bannwarth P Netter J Pourel RJ Royer A Gaucher 1989 Clinical pharmacokinetics of nonsteroidal anti-inflammatory drugs in the cerebrospinal fluid Biomed Pharmacother 43 121 126 10.1016/0753-3322(89)90140-6
    • (1989) Biomed Pharmacother , vol.43 , pp. 121-126
    • Bannwarth, B.1    Netter, P.2    Pourel, J.3    Royer, R.J.4    Gaucher, A.5
  • 15
    • 0029917887 scopus 로고    scopus 로고
    • Anti-inflammatory drugs in the fight against Alzheimer's disease
    • 10.1111/j.1749-6632.1996.tb34421.x
    • PL McGeer EG McGeer 1996 Anti-inflammatory drugs in the fight against Alzheimer's disease Ann N Y Acad Sci 777 213 220 10.1111/j.1749-6632.1996. tb34421.x
    • (1996) Ann N Y Acad Sci , vol.777 , pp. 213-220
    • McGeer, P.L.1    McGeer, E.G.2
  • 16
    • 7244226629 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action
    • 10.1111/j.1471-4159.2004.02743.x
    • L Gasparini E Ongini G Wenk 2004 Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action J Neurochem 91 521 536 10.1111/j.1471-4159.2004.02743.x
    • (2004) J Neurochem , vol.91 , pp. 521-536
    • Gasparini, L.1    Ongini, E.2    Wenk, G.3
  • 17
  • 18
    • 30044447532 scopus 로고    scopus 로고
    • Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models
    • Y Joo HS Kim RS Woo CH Park KY Shin JP Lee KA Chang S Kim YH Suh 2006 Mefenamic acid shows neuroprotective effects and improves cognitive impairment in in vitro and in vivo Alzheimer's disease models Mol Pharmacol 69 76 84
    • (2006) Mol Pharmacol , vol.69 , pp. 76-84
    • Joo, Y.1    Kim, H.S.2    Woo, R.S.3    Park, C.H.4    Shin, K.Y.5    Lee, J.P.6    Chang, K.A.7    Kim, S.8    Suh, Y.H.9
  • 19
    • 0032548765 scopus 로고    scopus 로고
    • Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina
    • 10.1016/S0304-3940(98)00081-0
    • Q Chen JW Olney PD Lukasiewicz T Almli C Romano 1998 Fenamates protect neurons against ischemic and excitotoxic injury in chick embryo retina Neurosci Lett 242 163 166 10.1016/S0304-3940(98)00081-0
    • (1998) Neurosci Lett , vol.242 , pp. 163-166
    • Chen, Q.1    Olney, J.W.2    Lukasiewicz, P.D.3    Almli, T.4    Romano, C.5
  • 20
    • 0025070929 scopus 로고
    • Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose-response relationships
    • 10.2165/00002018-199005040-00003
    • SC Smolinske AH Hall SA Vandenberg DG Spoerke PV McBride 1990 Toxic effects of nonsteroidal anti-inflammatory drugs in overdose. An overview of recent evidence on clinical effects and dose-response relationships Drug Saf 5 252 274 10.2165/00002018-199005040-00003
    • (1990) Drug Saf , vol.5 , pp. 252-274
    • Smolinske, S.C.1    Hall, A.H.2    Vandenberg, S.A.3    Spoerke, D.G.4    McBride, P.V.5
  • 21
    • 0028168114 scopus 로고
    • Excitotoxic mechanisms in the pathogenesis of dementia
    • 10.1016/0197-0186(94)90064-7
    • PR Dodd HL Scott RI Westphalen 1994 Excitotoxic mechanisms in the pathogenesis of dementia Neurochem Int 25 203 219 10.1016/0197-0186(94)90064-7
    • (1994) Neurochem Int , vol.25 , pp. 203-219
    • Dodd, P.R.1    Scott, H.L.2    Westphalen, R.I.3
  • 22
    • 0030872412 scopus 로고    scopus 로고
    • Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression
    • 10.1097/00005072-199708000-00008
    • S Li M Mallory M Alford S Tanaka E Masliah 1997 Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression J Neuropathol Exp Neurol 56 901 911 10.1097/00005072-199708000-00008
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 901-911
    • Li, S.1    Mallory, M.2    Alford, M.3    Tanaka, S.4    Masliah, E.5
  • 23
    • 0036479889 scopus 로고    scopus 로고
    • Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease
    • HL Scott DV Pow AE Tannenberg PR Dodd 2002 Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease J Neurosci 22 RC206
    • (2002) J Neurosci , vol.22 , pp. 206
    • Scott, H.L.1    Pow, D.V.2    Tannenberg, A.E.3    Dodd, P.R.4
  • 24
    • 0037312280 scopus 로고    scopus 로고
    • Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a
    • 10.1046/j.1471-4159.2003.01549.x
    • RJ Pearlman KR Aubrey RJ Vandenberg 2003 Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a J Neurochem 84 592 601 10.1046/j.1471-4159.2003.01549.x
    • (2003) J Neurochem , vol.84 , pp. 592-601
    • Pearlman, R.J.1    Aubrey, K.R.2    Vandenberg, R.J.3
  • 26
    • 0032511029 scopus 로고    scopus 로고
    • Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2
    • 10.1074/jbc.273.24.14698
    • AD Mitrovic SG Amara GA Johnston RJ Vandenberg 1998 Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2 J Biol Chem 273 14698 14706 10.1074/jbc.273.24.14698
    • (1998) J Biol Chem , vol.273 , pp. 14698-14706
    • Mitrovic, A.D.1    Amara, S.G.2    Johnston, G.A.3    Vandenberg, R.J.4
  • 27
    • 0033921196 scopus 로고    scopus 로고
    • Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b
    • KR Aubrey AD Mitrovic RJ Vandenberg 2000 Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b Mol Pharmacol 58 129 135
    • (2000) Mol Pharmacol , vol.58 , pp. 129-135
    • Aubrey, K.R.1    Mitrovic, A.D.2    Vandenberg, R.J.3
  • 28
    • 0033043034 scopus 로고    scopus 로고
    • Characterization of multiple forms of the human glycine transporter type-2
    • 10.1016/S0169-328X(99)00135-7
    • MJ Gallagher LH Burgess KR Brunden 1999 Characterization of multiple forms of the human glycine transporter type-2 Brain Res Mol Brain Res 70 101 115 10.1016/S0169-328X(99)00135-7
    • (1999) Brain Res Mol Brain Res , vol.70 , pp. 101-115
    • Gallagher, M.J.1    Burgess, L.H.2    Brunden, K.R.3
  • 29
    • 2542493963 scopus 로고    scopus 로고
    • 2+ inhibits glycine transport by glycine transporter subtype 1b
    • 10.1074/jbc.M312484200
    • 2+ inhibits glycine transport by glycine transporter subtype 1b J Biol Chem 279 22983 22991 10.1074/jbc.M312484200
    • (2004) J Biol Chem , vol.279 , pp. 22983-22991
    • Ju, P.1    Aubrey, K.R.2    Vandenberg, R.J.3
  • 30
    • 0030946093 scopus 로고    scopus 로고
    • Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2
    • RJ Vandenberg AD Mitrovic M Chebib VJ Balcar GA Johnston 1997 Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2 Mol Pharmacol 51 809 815
    • (1997) Mol Pharmacol , vol.51 , pp. 809-815
    • Vandenberg, R.J.1    Mitrovic, A.D.2    Chebib, M.3    Balcar, V.J.4    Johnston, G.A.5
  • 31
    • 0031849828 scopus 로고    scopus 로고
    • Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions
    • RJ Vandenberg AD Mitrovic GA Johnston 1998 Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions Mol Pharmacol 54 189 196
    • (1998) Mol Pharmacol , vol.54 , pp. 189-196
    • Vandenberg, R.J.1    Mitrovic, A.D.2    Johnston, G.A.3
  • 32
    • 0034721194 scopus 로고    scopus 로고
    • Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors
    • 10.1021/jm000004e
    • AS Kalgutkar AB Marnett BC Crews RP Remmel LJ Marnett 2000 Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors J Med Chem 43 2860 2870 10.1021/jm000004e
    • (2000) J Med Chem , vol.43 , pp. 2860-2870
    • Kalgutkar, A.S.1    Marnett, A.B.2    Crews, B.C.3    Remmel, R.P.4    Marnett, L.J.5
  • 33
    • 8544250631 scopus 로고    scopus 로고
    • Allosteric modulation of neurotransmitter transporters at excitatory synapses
    • 10.1016/j.ejps.2004.05.006
    • RJ Vandenberg P Ju KR Aubrey RM Ryan AD Mitrovic 2004 Allosteric modulation of neurotransmitter transporters at excitatory synapses Eur J Pharm Sci 23 1 11 10.1016/j.ejps.2004.05.006
    • (2004) Eur J Pharm Sci , vol.23 , pp. 1-11
    • Vandenberg, R.J.1    Ju, P.2    Aubrey, K.R.3    Ryan, R.M.4    Mitrovic, A.D.5
  • 34
    • 0035854771 scopus 로고    scopus 로고
    • 2+ inhibits the anion conductance of the glutamate transporter EAAT4
    • 10.1074/jbc.M011318200
    • 2+ inhibits the anion conductance of the glutamate transporter EAAT4 J Biol Chem 276 26071 26076 10.1074/jbc.M011318200
    • (2001) J Biol Chem , vol.276 , pp. 26071-26076
    • Mitrovic, A.D.1    Plesko, F.2    Vandenberg, R.J.3
  • 35
    • 0035909950 scopus 로고    scopus 로고
    • Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance
    • 10.1073/pnas.011400198
    • RP Seal Y Shigeri S Eliasof BH Leighton SG Amara 2001 Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductance Proc Natl Acad Sci USA 98 15324 15329 10.1073/pnas.011400198
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 15324-15329
    • Seal, R.P.1    Shigeri, Y.2    Eliasof, S.3    Leighton, B.H.4    Amara, S.G.5
  • 36
    • 0030068054 scopus 로고    scopus 로고
    • Involvement of arginine 120, glutamate 524, tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1
    • 10.1074/jbc.271.33.20175
    • DK Bhattacharyya M Lecomte CJ Rieke M Garavito WL Smith 1996 Involvement of arginine 120, glutamate 524, tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1 J Biol Chem 271 2179 2184 10.1074/jbc.271.33.20175
    • (1996) J Biol Chem , vol.271 , pp. 2179-2184
    • Bhattacharyya, D.K.1    Lecomte, M.2    Rieke, C.J.3    Garavito, M.4    Smith, W.L.5
  • 37
    • 0030783709 scopus 로고    scopus 로고
    • The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs
    • GM Greig DA Francis JP Falgueyret M Ouellet MD Percival P Roy C Bayly JA Mancini GP O'Neill 1997 The interaction of arginine 106 of human prostaglandin G/H synthase-2 with inhibitors is not a universal component of inhibition mediated by nonsteroidal anti-inflammatory drugs Mol Pharmacol 52 829 838
    • (1997) Mol Pharmacol , vol.52 , pp. 829-838
    • Greig, G.M.1    Francis, D.A.2    Falgueyret, J.P.3    Ouellet, M.4    Percival, M.D.5    Roy, P.6    Bayly, C.7    Mancini, J.A.8    O'Neill, G.P.9
  • 38
    • 0028783912 scopus 로고
    • Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety
    • 10.1074/jbc.270.49.29372
    • JA Mancini D Riendeau JP Falgueyret PJ Vickers GP O'Neill 1995 Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety J Biol Chem 270 29372 29377 10.1074/jbc.270.49.29372
    • (1995) J Biol Chem , vol.270 , pp. 29372-29377
    • Mancini, J.A.1    Riendeau, D.2    Falgueyret, J.P.3    Vickers, P.J.4    O'Neill, G.P.5
  • 40
    • 0029040041 scopus 로고
    • Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs
    • WL Smith DL DeWitt 1995 Biochemistry of prostaglandin endoperoxide H synthase-1 and synthase-2 and their differential susceptibility to nonsteroidal anti-inflammatory drugs Semin Nephrol 15 179 194
    • (1995) Semin Nephrol , vol.15 , pp. 179-194
    • Smith, W.L.1    Dewitt, D.L.2
  • 41
    • 0344938274 scopus 로고    scopus 로고
    • The structural and electronical factors that contribute affinity for the time-dependent inhibition of PGHS-1 by indomethacin, diclofenac and fenamates
    • 10.1023/A:1008094616324
    • R Pouplana C Perez J Sanchez JJ Lozano P Puig-Parellada 1999 The structural and electronical factors that contribute affinity for the time-dependent inhibition of PGHS-1 by indomethacin, diclofenac and fenamates J Comput Aided Mol Des 13 297 313 10.1023/A:1008094616324
    • (1999) J Comput Aided Mol des , vol.13 , pp. 297-313
    • Pouplana, R.1    Perez, C.2    Sanchez, J.3    Lozano, J.J.4    Puig-Parellada, P.5
  • 42
    • 0000151210 scopus 로고
    • Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs
    • 10.1073/pnas.72.12.4863
    • LH Rome WE Lands 1975 Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs Proc Natl Acad Sci USA 72 4863 4865 10.1073/pnas.72.12.4863
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 4863-4865
    • Rome, L.H.1    Lands, W.E.2
  • 43
    • 28044448943 scopus 로고    scopus 로고
    • Pericapillary haem-rich deposits: Evidence for microhaemorrhages in aging human cerebral cortex
    • 10.1038/sj.jcbfm.9600155
    • KM Cullen Z Kocsi J Stone 2005 Pericapillary haem-rich deposits: evidence for microhaemorrhages in aging human cerebral cortex J Cereb Blood Flow Metab 25 1656 1667 10.1038/sj.jcbfm.9600155
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1656-1667
    • Cullen, K.M.1    Kocsi, Z.2    Stone, J.3
  • 44
    • 0036895241 scopus 로고    scopus 로고
    • Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS
    • 10.1002/ana.10374
    • DB Drachman K Frank M Dykes-Hoberg P Teismann G Almer S Przedborski JD Rothstein 2002 Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS Ann Neurol 52 771 778 10.1002/ana.10374
    • (2002) Ann Neurol , vol.52 , pp. 771-778
    • Drachman, D.B.1    Frank, K.2    Dykes-Hoberg, M.3    Teismann, P.4    Almer, G.5    Przedborski, S.6    Rothstein, J.D.7


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