Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer

British Journal of Cancer

Volumn 94, Issue 11, 2006, Pages 1683-1689

  Beskow, C ^a   Kanter, L ^a   Holgersson, A ^b   Nilsson, B ^a   Frankendal, B ^a   Avall Lundqvist E ^a   Lewensohn, R ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Cervical cancer; DNA PK; Mdm2; p21; p53; Radiosensitivity

Indexed keywords

FORMALDEHYDE; KU ANTIGEN; PROTEIN KU86; PROTEIN MDM2; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BRACHYTHERAPY; CANCER RADIOTHERAPY; CANCER REGRESSION; CANCER STAGING; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IONIZING RADIATION; MAJOR CLINICAL STUDY; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR BIOPSY; UTERINE CERVIX CANCER;

DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM PROTEINS; NEOPLASM STAGING; TREATMENT OUTCOME; UTERINE CERVICAL NEOPLASMS;

EID: 33745257582     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603153     Document Type: Article

References (44)

1. Allalunis-Turner MJ, Barron GM, Day III RS, Dobler KD, Mirzayans R (1993) Isolation of two cell lines from a human malignant glioma specimen differing in sensitivity to radiation and chemotherapeutic drugs. Radiat Res 134: 349-354
2. Bartkova J, Horejsi Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Orntoft T, Lukas J, Bartek J (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorgenesis. Nature 434: 864-870
3. Benjamin I, Saigo P, Finstad C, Takahashi H, Federici M, Rubin SC, Boyd J (1996) Expression and mutational analysis of P53 in stage IB and IIA cervical cancers. Am J Obstet Gynecol 175: 1266-1271
4. Beskow C, Ågren-Cronqvist A-K, Granath F, Frankendal B, Lewensohn R (2002) Pathologic complete remission after preoperative intracavitary radiotherapy of cervical cancer stage Ib and IIa is a strong prognostic factor for long-term survival: analysis of the Radiumhemmet data 1989-1991. Int J Gynecol Cancer 12: 158-170
5. Björk-Eriksson T, West C, Nilsson A, Magnusson B, Svensson M, Karlsson E, Slevin N, Lewensohn R, Mercke C (1999) The immunohistochemical expression of DNA-PKcs and Ku (p70/p80) in head and neck cancers: relationships with radiosensitivity. Int J Radiat Oncol Biol Phys 45: 1005-1010
6. Blunt T, Finnie NJ, Taccioli GE, Smith GC, Demengeot J, Gottlieb TM, Mizuta R, Varghese AJ, Alt FW, Jeggo PA, Jackson SP (1995) Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Cell 80: 813-823
7. DeFazio LG, Stansel RM, Griffith JD, Chu G (2002) Synapsis of DNA ends by DNA-dependent protein kinase. EMBO J 21: 3192-3200
8. Ding Q, Bramble L, Yuzbasiyan-Gurkan V, Bell T, Meek K (2002) DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. Gene 283: 263-269
9. Dynan WS, Yoo S (1998) Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids. Nucl Acids Res 26: 1551-1559
10. Ebara T, Mitsuhashi N, Saito Y, Sakuri H, Sakurai H, Hasegawa M, Takahashi M, Takahashi T, Hayakawa K, Niibe H (1996) Prognostic significance of immunohistochemically detected p53 protein expression in stage IIIb squamous cell carcinoma of the uterine cervix treated with radiation therapy alone. Gynecol Oncol 63: 216-218
11. Eifel P, Morris M, Wharton T, Oswald MJ (1994) The influence of tumor size and morphology on the outcome of patients with FIGO stage IB squamous cell carcinoma at the uterine cervix. Int J Radiat Oncol Biol Phys 29: 9-16
12. el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825
13. Friesland S, Kanter-Lewensohn L, Tell R, Munck-Wikland E, Lewensohn R, Nilsson A (2003) Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy. Head Neck 25: 313-321
14. Harima Y, Sawada S, Miyazaki Y, Kin K, Ishihara H, Imamura M, Sougawa M, Shikata N, Ohnishi T (2003) Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival. Am J Clin Oncol 26: 80-85
15. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816
16. Hefferin ML, Tomkinson AE (2005) Mechanism of DNA double-strand break repair by non-homologous end joining. DNA Repair 4: 639-648
17. Hosoi Y, Watanabe T, Nakagawa K, Matsumoto Y, Enomoto A, Morita A, Nagawa H, Suzuki N (2004) Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int J Oncol 25: 461-468
18. Jeggo PA, Taccioli GE, Jackson SP (1995) Menage a trios: double strand break repair, V(D)J recombination and DNA-PK. Bioessays 17: 949-957
19. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW (1991) Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311
20. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, Oettinger MA, Brown JM (1995) DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267: 1178-1183
21. Komuro Y, Watanabe T, Hosoi Y, Matsumoto Y, Nakagawa K, Saito S, Ishihara S, Kazama S, Tsuno N, Kitayama J, Suzuki N, Tsurita G, Muto T, Nagawa H (2003) Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. J Exp Clin Cancer Res 22: 223-228
22. Lavin MF, Shiloh Y (1997) The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 15: 177-202
23. Lees-Miller SP, Sakaguchi K, Ullrich SJ, Appella E, Anderson CW (1992) Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53. Mol Cell Biol 12: 5041-5049
24. Mayo LD, Turchi JJ, Berberich SJ (1997) Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53. Cancer Res 57: 5013-5016
25. Meek K, Kienker L, Dallas C, Wang W, Dark MJ, Venta PJ, Huie ML, Hirschhorn R, Bell T (2001) SCID in Jack Russell terriers: a new animal model of DNA-PKcs deficiency. J Immunol 167: 2142-2150
26. Mimori T, Hardin JA (1986) Mechanism of interaction between Ku protein and DNA. J Biol Chem 261: 10375-10379
27. Mukherjee G, Freeman A, Moore R, Kumaraswamy, Devi KU, Morris LS, Coleman N, Dilworth S, Prabhakaran PS, Stanley MA (2001) Biologic factors and response to radiotherapy in carcinoma of the cervix. Int J Gynecol Cancer 11: 187-193
28. Perez C, Grigsby P, Chao C, Mutch D, Lockett MA (1998) Tumor size, irradiation dose, and long-term outcome of carcinoma of uterine cervix. Int J Radiat Oncol Biol Phys 41: 307-317
29. Rotman G, Shiloh Y (1999) ATM: a mediator of multiple responses to genotoxic stress. Oncogene 18: 6135-6144
30. Scheffner M, Werness BA, Huibregtse JM, Levine AJ, Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63: 1129-1136
31. Schneider J, Rubio MP, Rodriguez-Escudero FJ, Seizinger BR, Castresana JS (1994) Identification of p53 mutations by means of single strand conformation polymorphism analysis in gynaecological tumours: comparison with the results of immunohistochemistry. Eur J Cancer 30A: 504-508
32. Shieh SY, Ikeda M, Taya Y, Prives C (1997) DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell 91: 325-334
33. Shiloh Y (2003) ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 3: 155-168
34. Shin EK, Perryman LE, Meek K (1997) A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation. J Immunol 158: 3565-3569
35. Sirzen F, Nilsson A, Zhivotovski B, Lewensohn R (1999) DNA-dependent protein kinase content and activity in lung carcinoma cell lines: Correlation with intrinsic radiosensitivity. Eur J Cancer 35: 111-116
36. Stronati L, Gensabella G, Lamberti C, Barattini P, Frasca D, Tanzarella C, Giacobini S, Toscano MG, Santacroce C, Danesi DT (2001) Expression and DNA binding activity of the Ku heterodimer in bladder carcinoma. Cancer 92: 2484-2492
37. Taccioli GE, Gottlieb TM, Blunt T, Priestley A, Demengeot J, Mizuta R, Lehmann AR, Alt FW, Jackson SP, Jeggo PA (1994) Ku80: Product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 265: 1442-1445
38. Troncone G, Martinez JC, Palombini L, De Rosa G, Mugica C, Rodriguez JA, Zeppa P, Di Vizio D, Lucariello A, Piris MA (1998) Immunohistochemical expression of mdm2 and p21WAF1 in invasive cervical cancer: correlation with p53 protein and high risk HPV infection. J Clin Pathol 51: 754-760
39. Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, Oren M, Haupt Y (1999) Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J 18: 1805-1814
40. Vousden KH (2000) p53: death star. Cell 103: 691-694
41. West CM, Davidson SE, Roberts SA, Hunter RD (1997) The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix. Br J Cancer 76: 1184-1190
42. Wiler R, Leber R, Moore BB, VanDyk LF, Perryman LE, Meek K (1995) Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity. Proc Natl Acad Sci USA 92: 11485-11489
43. Wilson CR, Davidson SE, Margison GP, Jackson SP, Hendry JH, West CM (2000) Expression of Ku70 correlates with survival in carcinoma of the cervix. Br J Cancer 83: 1702-1706
44. Zhao HJ, Hosoi Y, Miyachi H, Ishii K, Yoshida M, Nemoto K, Takai Y, Yamada S, Suzuki N, Ono T (2000) DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cancer cell lines. Clin Cancer Res 6: 1073-1078