Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

Cytotechnology

Volumn 27, Issue 1-3, 1998, Pages 137-148

  Izquierdo, Miguel A ^a,b   Scheffer, George L ^a   Schroeijers, Anouk B ^b   De Jong, Mariska C ^a   Scheper, Rik J ^a  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Drug resistance; Lung resistance related protein; Multidrug resistance; Multidrug resistance protein; P glycoprotein; Vaults

Indexed keywords

MULTIDRUG RESISTANCE; PROTEIN EXPRESSION; VAULT PROTEIN;

EID: 0032413757     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1007/978-94-017-2374-9_8     Document Type: Article

References (59)

1. Biedler JL (1994) Drug resistance: genotype versus phenotype. Cancer Res, 666-678.
2. Chugani DC, Kedersha ML, Rome LH (1991) Vault immunofluorescence in the brain: New insights regarding the origin of microglia. J Neurosci 11: 256-268.
3. Chugani DC, Rome LH, Kedersha NL (1993) Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J Cell Sci 106:23-29.
4. Coley HM, Amos WB, Twentyman PR, Workman P (1993) Examination by laser scanning confocal fluorescence imaging microscopy of the subcellular localisation of anthracyclines in parent and multidrug resistant cell lines. Br J Cancer 67: 13161323.
5. Den Boer ML, Zwaan CM, Pieters R, Kazemier KM, Rottier MMA, Flens MJ, Scheper RJ, Veerman AJP (1997) Optimal immunocytochemical and flow cytometric detection of P-gp, MRP, and LRP in childhood acute lymphoblastic leukaemia. Leukaemia 11: 1078-1085.
6. Dietel M, Arps H, Lage H, Niendorf A (1990) Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257. Cancer Research 50: 6100-6106.
7. Dingemans AMC, van Ark-Otte J, van der Valk P, Apolinario RM, Scheper RJ, Postmus PE, Giaccone G (1996) Expression of the human major vault protein LRP in human lung cancer samples and normal lung tissue. Ann Oncol 7: 625-630.
8. Filipits M, Pohl G, Stranzl T, Suchomel RW, Scheper RJ, Jager U, Geissler K, Lechner K and Pirker R (1998) Expression of the Lung Resistance Protein (LRP) predicts poor outcome in de novo acute myeoloid leukemia. Blood 91: 1508-1513.
9. Flens MJ, Izquierdo MA, Scheffer GL, Fritz JM, Meijer CJLM, Scheper RJ, Zaman GJR (1994) Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumour cells by monoclonal antibodies. Cancer Res 54: 4557-4563.
10. Flens MJ, Zaman GJR, van der Valk P, Izquierdo MA, Schroeijers AB, Scheffer GL, van der Groep P, de Haas M, Meijer CJLM, Scheper RJ (1996) Tissue distribution of the multidrug resistance protein. Am J Pathol 148: 1237-1247.
11. Flens MJ, Scheffer GL, van der Valk P, Broxterman HJ, Eijdems EWHM, Huysmans ACLM, Izquierdo MA, Scheper RJ (1997) Identification of novel drug resistance-associated proteins by a panel of rat monoclonal antibodies. Int J Cancer, in press.
12. Futscher BW, Abbaszadegan MR, Domann F, Dalton WS (1994) Analysis of MRP MRNA in mitoxantrone-selected, multidrugresistant human tumour cells. Biochem Pharmacol 47: 16011606.
13. Garbe C (1993) Chemotherapy and chemoimmunotherapy in disseminated malignant melanoma. Melanoma Res 3: 291-299.
14. Gervasoni JE Jr, Fields SZ, Krishna S, Baker MA, Rosado M, Thuraisamy K, Hindenburg AA, Taub RN (1991) Subcellular distribution of daunorubicin in P-glycoprotein-positive and negative drug-resistant cell lines using laser-assisted confocal microscopy. Cancer Research 51: 4955-4963.
15. Goldstein LJ, Pastan I, Gottesman MM (1992) Multidrug resistance in human cancer. (Review). Critical Reviews in OncologyHematology 12: 243-253.
16. Hart SM, Ganeshaguru K, Scheper RJ, Hoffbrand AV, Mehta AB (1995) Expression of the human major vault protein in haematological malignancies. Amer Soc Haematol Dec, (Abstract).
17. Herrmann C, Volknandt W, Wittich B, Kellner R, Zimmermann H (1996) The major vault protein (MVP100) is contained in cholinergic nerve terminals of electric ray organ. J Biol Chem 271: 13908-13915.
18. Higgins CF (1992) ABC Transporters - From Microorganisms to Man. Annu Rev Cell Biol 8: 67-113.
19. Hindenburg AA, Gervasoni JE,Jr., Krishna S, Stewart VJ, Rosado M, Lutzky J, Bhalla K, Baker MA, Taub RN (1989) Intracellular distribution and pharmacokinetics of daunorubicin in anthracycline-sensitive and -resistant HL-60 cells. Cancer Research 49: 4607-4614.
20. Ikeda K, Oka M, Narasaki F, Nakano R, Fukuda M, Mizuta Y, Yamada Y, Kamihira K, Tomonaga M, Kohno S ( 1997) LRPm gene expression in human gastric cancers, and adult T-cell leukaemia cells. Procc Am Ass Cancer Res 390 (abst. 2616).
21. Izquierdo MA, van der Zee AGJ, Vermerken JB, van der Valk P, Belien JAM, Giaccone G, Scheffer GL, Flens MI, Pinedo HM, Kenemans P, Meijer CJLM, de Vries EOF, Scheper RJ (1995) Drug resistance-associated marker LRP for prediction of response to chemotherapy and prognoses in advanced ovarian carcinoma. J Nat Cancer Inst 87: 1230-1237.
22. Izquierdo MA, Scheffer GL, Flens MI, Giaccone G, Broxterman HJ, Meijer CJLM, van der Valk P, Scheper RJ (1996a) Broad distribution of the multidrug resistance-related vault lung resistance protein in normal human tissues and tumours. Am J Pathol 148: 877-887.
23. Izquierdo MA, Shoemaker RH, Flens MI, Scheffer GL, Wu L, Prather TR, Scheper RJ (1996b) Overlapping phenotypes of multidrug resistance among panels of human cancer-cell lines. Int J Cancer 65: 230-237.
24. Izquierdo MA, Scheffer GL, Flens MJ, Schroeijers AB, van der Valk P, Scheper RJ (1996c) Major vault protein LRP-related multidrug resistance. Fur J Cancer 32A: 979-984.
25. Kedersha NL and Rome LH (1986) Isolation and characterization of a novel ribonucleoprotein particle:large structures contain a single species of small RNA. J Cell Biol 103: 699-709.
26. Kedersha NL, Miquel M-C, Bittner D, Rome LH (1990) Vaults II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes. J Cell Biol 110: 895-901.
27. Kedersha NL, Heuser JE, Chugani DC, Rome LH (1991) Vaults III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry. J Cell Biol 112: 225-235.
28. Kedersha NL, Rome LH (1993) CDNA cloning and disruption of the major vault protein alpha (mvpA) in Dictyostelium discoideum. J Biol Chem 268: 15356-15360.
29. Kickhoefer VA, Searles RP, Kedersha NL, Garber ME, Johnson DL, Rome LH (1993) Vault ribonucleoprotein particles from rat and bullfrog contain related small RNA that is transcribed by RNA polymerase III. J Biol Chem 268: 7868-7873.
30. Kickhoefer VA, Rome LH (1994) The sequence of a CDNA encoding the major vault protein from Rattus norvegiens. Gene 151: 257-260.
31. Kickhoefer VA, Rajavel KS, Scheffer GL, Dalton WS, Scheper RJ, Rome LH (1998) Vaults are up-regulated in multidrug resistant cancer cell lines. J Biol Chem 273: 8971-8974.
32. Klumper E, de Boer ML, Pieters R, Huismans DR, Rottier MMA, Zwaan MC, Scheffer GL, Scheper RJ, Veerman AJP (1995) Non-P-glycoprotein mediated resistance to anthracyclines is associated with the expression of a 110 Kd protein in relapsed childhood acute lymphoblastic leukaemia. In: Klumper E. Thesis. VU University Press, pp. 117-130.
33. Komarov P, Shtil A, Buckingman L, Roninson I, Coon J (1997) Genes encoding for different drug resistance-associated proteins (MDR1, LRP, and MRP) are differentially regulated by extracellular stimuli. Procc Am Ass Cancer Res 479 (abst. 3207).
34. Kuiper CM, Broxterman HJ, Baas F, Schuurhuis GJ, Haisma HJ, Scheffer GL, Lankelma J, Pinedo HM (1990) Drug transport variants without P-glycoprotein overexpression from a human squamous lung cancer cell line after selection with doxorubicin. J Cell Pharmacol 1: 35-31.
35. Laurencot CM, Scheffer GL, Scheper RJ, Shoemaker RH (1997) Increased LRP MRNA expression is associated with the MDR phenotype in intrinsically resistant human cancer cell lines. Int J Cancer 72: 1-6.
36. List AF, Spier CS, Grogan TM, Johnson C, Roe DJ, Greer JP, Wolff SN, Broxterman HJ, Scheffer GL, Scheper RJ, Dalton WS (1996) Overexpression of the major vault transporter protein Lung Resistance Protein predicts treatment outcome in acute myeloid leukaemia. Blood 87: 2464-2469.
37. Loe DW, Deeley RG, Cole SPC (1996) Biology of the multidrug resistance-associated protein, MRP. Eur J Cancer 32A: 945-957.
38. Moran E, Clearly I, Larkin AM, Amhlaoibh RN, Masterson A, Scheper RJ, Izquierdo MA, Center M, O'Sullivan F, Clynes M (1997) Co-expression of MDR-associated markers, including P170, MRP and LRP and cytoskeletal proteins, in three resistant variants of the human ovarian carcinoma cell line, OAW42. Eur J Cancer 33: 652-660.
39. Michieli M, Damiani D, Ermacora A, Raspadori D, Michelutti A, Grimaz S, Fanin R, Russo D, Lauria F, Masolini P, Baccarani M (1997) P-glycoprotein (POP) and lung resistance-related protein (LRP) expression and function in leukaemic blast cells. Br J Haematol 96: 356-365.
40. Parker R, Mechetner E, Garcia R, Pavich D, Fruehauf J (1997) Acquired cisplatin resistance in human ovarian cancer A2780/CP70 cells is associated with MRP and LRP over-expression. Procc Am Ass Cancer Res 481 (abst. 3219).
41. Pieters R, Klumper E, Kaspers GJL, Veerman AJP (1997) Everything you always wanted to know about cellular drug resistance in childhood acute lymphoblastic leukaemia. Crit Rev Oncol Hematol25: 11-26.
42. Ramani P, Dewchand H (1995) Expression of mdr//P-glycoprotein and pi 10 in neuroblastoma. J Pathol 175: 13-22.
43. Rome LH, Kedersha ML, Chugani DC (1991) Unlocking vaults: organelles in search of a function. Trends Cell Biol 1: 47-50.
44. Schadendorf D, Herfordt R, Czarnetzki BM (1995a) P-glycoprotein expression in primary and metastatic malignant melanoma. Br J Dermatol 132:551-555.
45. Schadendorf D, Makki A, Stahr C, van Dyck A, Wanner R, Scheffer GL, Flens MI, Scheper RJ, Henz BM (1995b) Membrane transport proteins associated with drug resistance expressed in human melanoma. Am J Pathol 147: 1545-1552.
46. Scheffer GL, Wijngaard PLJ, Flens MI, Izquierdo MA, Slovak ML, Pinedo HM, Meijer CJLM, Clevers HC, Scheper RJ (1995) The drug resistance-related protein LRP is the human major vault protein. Nature Med 1: 578-582.
47. Scheper RJ, Broxterman HJ, Scheffer GL, Kaaijk P, Dalton WS, van Heijningen THM, van Kalken CK, Slovak ML, Devries EGE, van der Valk P, Meijer CJLM, Pinedo HM (1993) Overexpression of a M(r) 110,000 Vesicular Protein in Non- P-Glycoprotein-Mediated Multidrug Resistance. Cancer Res 53: 1475-1479.
48. Schroeijers AB, Scheffer GL, Flens MI, Meijer GA, van der Valk P, Scheper RJ (1998) Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies LRP56 and LMR-5 in formalin-fixed, paraffin-embedded tissues. Am J Pathol 152: 373-378.
49. Schuurhuis GJ, Broxterman HJ, Cervantes A, van Heijningen TH, de Lange JH, Baak JP, Pinedo HM, Lankelma J (1989) Quantitative determination of factors contributing to doxorubicin resistance in multidrug-resistant cells. Journal of the National Cancer Institute 81: 1887-1892.
50. Shao Y, De Giuli R, Wyler B, Lehnert M (1995) Overexpression of MDRl/P-glycoprotein and MRP but not LRP is mutually exclusive in multidrug resistant human myeloma cells selected with doxorubicin. Proc Am Ass Cancer Res 36: 337 (abst 2006).
51. Slovak ML, Ho JP, Cole SPC, Deeley RG, Greenberger L, de Vries EGE, Broxterman HJ, Scheffer GL, Scheper RJ (1995) The LRP gene encoding a major vault protein associated with drug resis-tance maps proximal to MRP on chromosome 16: evidence that chromosome breakage plays a key role in MRP or LRP gene amplification. Cancer Res 55: 4214-4219.
52. Stein U, Walther W, CM, Scheffer GL, Scheper RJ, Shoemaker RH (1997) Tumour necrosis factor-α and expression of the multidrug resistance-associated genes LRP and MRP. J Natl Cancer Inst 89: 807-813.
53. Sugawara I, Akiyama S, Scheper RJ, Itoyama S (1997) Lung resistance protein (LRP) expression in human normal tissues in comparison with that of MDR1 and MRP. Cancer Let 112: 23-31.
54. van der Valk P, van Kalken CK, Ketelars H, Broxterman HJ, Scheffer GL, Kuiper CM, Tsuruo T, Lankelma J, Meijer CJLM, Pinedo HM, Scheper RJ (1990) Distribution of multi-drug resistanceassociated P-glycoprotein in normal and neoplastic human tissues. Ann Oncol 1: 56-64.
55. Vasu SK, Rome LH (1995) Dictyostelium vaults: Disruption of the major proteins reveals growth and morphological defects and uncovers a new associated protein. J Biol Chem 270: 16588-16594.
56. Veerman AJP, den Boer ML, Pieters R, Kazemier KM, Rottier MMA, Kaspers GJL, Scheper RJ, Janka G, Henze G, Creutzig U (1997) Intracellular daunorubicin concentrations and LRP are related to drug resistance in childhood leukaemia. Procc Am Ass Cancer Res 422 (abst. 2958).
57. Verovski VN, van der Berge DL, Delvaeye MM, Scheper RJ, De Neve WJ, Storme GA (1996) Low-level doxorubicin resistance in P-glycoprotein-negative human pancreatic tumour PSN1/ADR cells implicates a brefeldin A-sensitive mechanism of drug extrusion. Br J Cancer 73: 596-602.
58. Versantvoort CHM, Withoff S, Broxterman HJ, Kuiper CM, Scheper RJ, Mulder NH, Devries EGE (1995) Resistance-associated factors in human small-cell lung-carcinoma GLC(4) sub-lines with increasing adriamycin resistance. Int J Cancer 61: 375-380.
59. Wyler B, Shao Y, Schneider E, Cianfriglia M, Scheper RJ, Frey BM, Gieseler F, Schmid L, Twentyman P, Lehnert M (1997) Intermittent exposure to doxorubicin in vitro selects for multifactorial non-P-glycoprotein-associated multidrug resistance in RPMI 8226 human myeloid cells. Br J Haematol 97: 65-75.