The group II metabotropic glutamate receptor agonist, DCG-IV, alleviates akinesia following intranigral or intraventricular administration in the reserpine-treated rat

British Journal of Pharmacology

Volumn 129, Issue 3, 2000, Pages 541-546

  Dawson, Lee ^a   Chadha, Anita ^a   Megalou, Maria ^a   Duty, Susan ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Akinesia; Autoreceptor; Basal ganglia; DCG IV; Metabotropic glutamate receptor; Parkinson's disease; Reserpine; Substantia nigra; Subthalamic nucleus

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; GLUTAMATE RECEPTOR AGONIST; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; RESERPINE;

AKINESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; LOCOMOTION; MALE; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; RAT; SUBSTANTIA NIGRA;

EID: 0033967160     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703105     Document Type: Article

References (22)

1. Battaglia, G., Monn, J.A. & Schoepp, D.D. (1997). In vivo inhibition of veratridine-evoked release of striatal excitatory amino acids by the group II metabotropic glutamate receptor agonist LY35470 in rats. Neurosci. Lett., 229, 161-164.
2. Benazzouz, A., Gross, C., Feger, J., Boraud, T. & Bioulac, B. (1993). Reversal of rigidity and improvement of motor performance by subthalamic high-frequency stimulation in MPTP-treated monkeys. Eur. J. Neurosci., 5, 382-389.
3. Bergman, H., Wichmann, T. & Delong, M.R. (1990). Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science, 249, 1346-1348.
4. 14C]GABA uptake in the basal ganglia of rats following lesions in the subthalamic region suggest a role for excitatory amino acids but not GABA-mediated transmission in subthalamic nucleus efferents. Exp. Neurol., 113, 171-181.
5. Calabresi, P., Centonze, D., Pisani, A. & Bernardi, G. (1999). Metabotropic glutamate receptors and cell-type-specific vulnerability in the rat striatum: implication for ischaemia and Huntington's disease. Exp. Neurol., 158, 97-108.
6. Conn, P.J. & Pin, J.P. (1997). Pharmacology and functions of metabotropic glutamate receptors. Ann. Rev. Pharmacol. Toxicol., 37, 205-237.
7. Dawson, L., Chadha, A. & Duty, S. (1999). Locomotor effects following injection of the group II mGluR agonist, DCG-IV, into the substantia nigra pars reticulata of the reserpine-treated rat model of Parkinson's disease. Br. J. Pharmacol., 126, 60P.
8. Ishida, M., Saitoh, T., Shimamoto, K., Ohfune, Y. & Shinozaki, H. (1993). A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the isolated newborn rat spinal cord. Br. J. Pharmacol., 109, 1169-1177.
9. 3H]-aspartate output in rat striatum. Br. J. Pharmacol., 110, 1407-1412.
10. Mitchell, I.J., Clarke, C.E., Boyce, S., Robertson, R.G., Peggs, D., Sambrook, M.A. & Crossman, A.R. (1989). Neural mechanisms underlying parkinsonian symptoms based on regional uptake of 2-deoxyglucose in monkeys exposed to 1-methyl-4-phenyl - 1,2,3,6,-tetrahydropyridine (MPTP). Neuroscience, 32, 213-226.
11. Miyamoto, M., Ishida, M. & Shinosaki, H. (1997). Anticonvulsive and neuroprotective actions of a potent agonist (DCG-IV) for group II metabotropic glutamate receptors against intraventricular kainate in the rat. Neuroscience, 77, 131-140.
12. Parent, A. & Hazrati, L.-N. (1995). Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop. Brain Res. Rev., 20, 91-127.
13. Paxinos, G. & Watson, C. (1986). The rat brain in stereotaxic coordinates, 2nd edn. U.K.: Academic Press.
14. Robledo, P. & Feger, J. (1990). Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data. Brain Res., 519, 47-54.
15. Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P., Neki, A., Abe, T., Nakanishi, S. & Mizuno, N. (1997). Different presynaptic localisation of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci. 17, 7503-7522.
16. Smith, Y., Bevan, M.D., Shink, E. & Bolam, J.P. (1998). Microcircuitry of the direct and indirect pathways of the basal ganglia. Neuroscience, 86, 353-387.
17. Starr, M.S., Starr, B.S. & Kaur, S. (1997). Stimulation of basal and L-DOPA-induced motor activity by glutamate antagonists in animal models of Parkinson's disease. Neurosci. Biobehav. Rev., 21, 437-446.
18. Stocchi, F., Nordera, G. & Marsden, C.D. (1997). Strategies for treating patients with advanced Parkinson's disease with disastrous fluctuation and dyskinesias. Clin. Neuropharmacol., 20, 95-115.
19. Testa, C.M., Friberg, I.K., Weiss, S.W. & Standaert, D.G. (1998). Immunohistochemical localisation of metabotropic glutamate receptors mGluR1a and mGluR2/3 in the rat basal ganglia. J. Comp. Neurol., 390, 5-19.
20. Testa, C.M., Standaert, D.G., Young, A.B. & Penney, J.B. (1994). Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J. Neurosci., 14, 3005-3018.
21. Wigmore, M.A. & Lacey, M.G. (1998). Metabotropic glutamate receptors depress glutamate-mediated synaptic input to rat midbrain dopamine neurones in vitro. Br. J. Pharmacol., 123, 667-674.
22. Yung, K.K. (1998). Localization of ionotropic and metabotropic glutamate receptors in distinct neuronal elements of rat substantia nigra. Neurochem. Int., 33, 313-326.