-
1
-
-
34250674386
-
Abnormal vertebral segmentation and the notch signaling pathway in man
-
Turnpenny P.D., Alman B., Cornier A.S., Giampietro P.F., Offiah A., Tassy O., Pourquie O., Kusumi K., and Dunwoodie S. Abnormal vertebral segmentation and the notch signaling pathway in man. Dev Dyn 236 (2007) 1456-1474
-
(2007)
Dev Dyn
, vol.236
, pp. 1456-1474
-
-
Turnpenny, P.D.1
Alman, B.2
Cornier, A.S.3
Giampietro, P.F.4
Offiah, A.5
Tassy, O.6
Pourquie, O.7
Kusumi, K.8
Dunwoodie, S.9
-
2
-
-
0035514186
-
The making of the somite: molecular events in vertebrate segmentation
-
Saga Y., and Takeda H. The making of the somite: molecular events in vertebrate segmentation. Nat Rev Genet 2 (2001) 835-845
-
(2001)
Nat Rev Genet
, vol.2
, pp. 835-845
-
-
Saga, Y.1
Takeda, H.2
-
4
-
-
33747623018
-
Notch signalling: a simple pathway becomes complex
-
Bray S.J. Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7 (2006) 678-689
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
5
-
-
34748851341
-
Cell and molecular biology of Notch
-
Fiuza U.M., and Arias A.M. Cell and molecular biology of Notch. J Endocrinol 194 (2007) 459-474
-
(2007)
J Endocrinol
, vol.194
, pp. 459-474
-
-
Fiuza, U.M.1
Arias, A.M.2
-
6
-
-
38549148417
-
Notch and cancer: a double-edged sword
-
Koch U., and Radtke F. Notch and cancer: a double-edged sword. Cell Mol Life Sci 64 (2007) 2746-2762
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2746-2762
-
-
Koch, U.1
Radtke, F.2
-
7
-
-
58649110008
-
Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine
-
Dunwoodie S.L. Mutation of the fucose-specific beta1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine. Biochim Biophys Acta 1792 (2009) 100-111
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 100-111
-
-
Dunwoodie, S.L.1
-
8
-
-
35549010538
-
Regulation of Notch signaling by glycosylation
-
Stanley P. Regulation of Notch signaling by glycosylation. Curr Opin Struct Biol 17 (2007) 530-535
-
(2007)
Curr Opin Struct Biol
, vol.17
, pp. 530-535
-
-
Stanley, P.1
-
9
-
-
46449089731
-
ADAM proteases: ligand processing and modulation of the Notch pathway
-
Zolkiewska A. ADAM proteases: ligand processing and modulation of the Notch pathway. Cell Mol Life Sci 65 (2008) 2056-2068
-
(2008)
Cell Mol Life Sci
, vol.65
, pp. 2056-2068
-
-
Zolkiewska, A.1
-
10
-
-
0031238781
-
An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila
-
Klein T., Brennan K., and Arias A.M. An intrinsic dominant negative activity of serrate that is modulated during wing development in Drosophila. Dev Biol 189 (1997) 123-134
-
(1997)
Dev Biol
, vol.189
, pp. 123-134
-
-
Klein, T.1
Brennan, K.2
Arias, A.M.3
-
11
-
-
33750202549
-
Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis
-
Glittenberg M., Pitsouli C., Garvey C., Delidakis C., and Bray S. Role of conserved intracellular motifs in Serrate signalling, cis-inhibition and endocytosis. EMBO J 25 (2006) 4697-4706
-
(2006)
EMBO J
, vol.25
, pp. 4697-4706
-
-
Glittenberg, M.1
Pitsouli, C.2
Garvey, C.3
Delidakis, C.4
Bray, S.5
-
12
-
-
0037081076
-
Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification
-
Sakamoto K., Ohara O., Takagi M., Takeda S., and Katsube K. Intracellular cell-autonomous association of Notch and its ligands: a novel mechanism of Notch signal modification. Dev Biol 241 (2002) 313-326
-
(2002)
Dev Biol
, vol.241
, pp. 313-326
-
-
Sakamoto, K.1
Ohara, O.2
Takagi, M.3
Takeda, S.4
Katsube, K.5
-
13
-
-
0030961091
-
Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
-
Dunwoodie S.L., Henrique D., Harrison S.M., and Beddington R.S. Mouse Dll3: a novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo. Development 124 (1997) 3065-3076
-
(1997)
Development
, vol.124
, pp. 3065-3076
-
-
Dunwoodie, S.L.1
Henrique, D.2
Harrison, S.M.3
Beddington, R.S.4
-
14
-
-
0030976083
-
Maintenance of somite borders in mice requires the Delta homologue DII1
-
Hrabe de Angelis M., McIntyre J., 2nd, and Gossler A. Maintenance of somite borders in mice requires the Delta homologue DII1. Nature 386 (1997) 717-721
-
(1997)
Nature
, vol.386
, pp. 717-721
-
-
Hrabe de Angelis, M.1
McIntyre, J.2
2nd3
Gossler, A.4
-
15
-
-
0036332950
-
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm
-
Dunwoodie S.L., Clements M., Sparrow D.B., Sa X., Conlon R.A., and Beddington R.S. Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesoderm. Development 129 (2002) 1795-1806
-
(2002)
Development
, vol.129
, pp. 1795-1806
-
-
Dunwoodie, S.L.1
Clements, M.2
Sparrow, D.B.3
Sa, X.4
Conlon, R.A.5
Beddington, R.S.6
-
16
-
-
34547566893
-
Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo
-
This study shows that the Dll3 ligand of Notch is distinct from the Dll1 ligand. The Dll3 cDNA, expressed from the Dll1 locus in mouse was unable to rescue the somite defect in Dll1 null embryos. Using unique antibodies to Dll1 and Dll3, it was revealed in the mouse embryonic presomitic mesoderm that Dll1 is localized to the cell surface as expected, and Dll3 is localized to the Golgi, which was an unexpected finding.
-
Geffers I., Serth K., Chapman G., Jaekel R., Schuster-Gossler K., Cordes R., Sparrow D.B., Kremmer E., Dunwoodie S.L., Klein T., et al. Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo. J Cell Biol 178 (2007) 465-476. This study shows that the Dll3 ligand of Notch is distinct from the Dll1 ligand. The Dll3 cDNA, expressed from the Dll1 locus in mouse was unable to rescue the somite defect in Dll1 null embryos. Using unique antibodies to Dll1 and Dll3, it was revealed in the mouse embryonic presomitic mesoderm that Dll1 is localized to the cell surface as expected, and Dll3 is localized to the Golgi, which was an unexpected finding.
-
(2007)
J Cell Biol
, vol.178
, pp. 465-476
-
-
Geffers, I.1
Serth, K.2
Chapman, G.3
Jaekel, R.4
Schuster-Gossler, K.5
Cordes, R.6
Sparrow, D.B.7
Kremmer, E.8
Dunwoodie, S.L.9
Klein, T.10
-
17
-
-
24944501849
-
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands
-
Using mammalian cells in culture it was shown that Dll3, unlike Dll1, could not bind Notch in trans and activate signaling. Instead, Dll3 acts solely as a cis-inhibitor of Notch signaling.
-
Ladi E., Nichols J.T., Ge W., Miyamoto A., Yao C., Yang L.T., Boulter J., Sun Y.E., Kintner C., and Weinmaster G. The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands. J Cell Biol 170 (2005) 983-992. Using mammalian cells in culture it was shown that Dll3, unlike Dll1, could not bind Notch in trans and activate signaling. Instead, Dll3 acts solely as a cis-inhibitor of Notch signaling.
-
(2005)
J Cell Biol
, vol.170
, pp. 983-992
-
-
Ladi, E.1
Nichols, J.T.2
Ge, W.3
Miyamoto, A.4
Yao, C.5
Yang, L.T.6
Boulter, J.7
Sun, Y.E.8
Kintner, C.9
Weinmaster, G.10
-
18
-
-
49449094586
-
A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition
-
X-ray structure identifies the sites of interaction between Notch1 and Jagged1. The DSL domain and EGF-like repeat 3 of Jagged1 interact with EGF-like repeats 11-13 of Notch1. Studies in Drosophila demonstrate that this surface of Jagged1 is required to activate Notch in trans and inhibit signaling in cis.
-
Cordle J., Johnson S., Tay J.Z., Roversi P., Wilkin M.B., de Madrid B.H., Shimizu H., Jensen S., Whiteman P., Jin B., et al. A conserved face of the Jagged/Serrate DSL domain is involved in Notch trans-activation and cis-inhibition. Nat Struct Mol Biol 15 (2008) 849-857. X-ray structure identifies the sites of interaction between Notch1 and Jagged1. The DSL domain and EGF-like repeat 3 of Jagged1 interact with EGF-like repeats 11-13 of Notch1. Studies in Drosophila demonstrate that this surface of Jagged1 is required to activate Notch in trans and inhibit signaling in cis.
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 849-857
-
-
Cordle, J.1
Johnson, S.2
Tay, J.Z.3
Roversi, P.4
Wilkin, M.B.5
de Madrid, B.H.6
Shimizu, H.7
Jensen, S.8
Whiteman, P.9
Jin, B.10
-
19
-
-
42349117524
-
Segmental patterning of the vertebrate embryonic axis
-
Dequeant M.L., and Pourquie O. Segmental patterning of the vertebrate embryonic axis. Nat Rev Genet 9 (2008) 370-382
-
(2008)
Nat Rev Genet
, vol.9
, pp. 370-382
-
-
Dequeant, M.L.1
Pourquie, O.2
-
20
-
-
34250639337
-
Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
-
Saga Y. Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity. Dev Dyn 236 (2007) 1450-1455
-
(2007)
Dev Dyn
, vol.236
, pp. 1450-1455
-
-
Saga, Y.1
-
21
-
-
34249693694
-
Ripply2 is essential for precise somite formation during mouse early development
-
Chan T., Kondow A., Hosoya A., Hitachi K., Yukita A., Okabayashi K., Nakamura H., Ozawa H., Kiyonari H., Michiue T., et al. Ripply2 is essential for precise somite formation during mouse early development. FEBS Lett 581 (2007) 2691-2696
-
(2007)
FEBS Lett
, vol.581
, pp. 2691-2696
-
-
Chan, T.1
Kondow, A.2
Hosoya, A.3
Hitachi, K.4
Yukita, A.5
Okabayashi, K.6
Nakamura, H.7
Ozawa, H.8
Kiyonari, H.9
Michiue, T.10
-
22
-
-
34248582613
-
The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite
-
Morimoto M., Sasaki N., Oginuma M., Kiso M., Igarashi K., Aizaki K., Kanno J., and Saga Y. The negative regulation of Mesp2 by mouse Ripply2 is required to establish the rostro-caudal patterning within a somite. Development 134 (2007) 1561-1569
-
(2007)
Development
, vol.134
, pp. 1561-1569
-
-
Morimoto, M.1
Sasaki, N.2
Oginuma, M.3
Kiso, M.4
Igarashi, K.5
Aizaki, K.6
Kanno, J.7
Saga, Y.8
-
23
-
-
68949132006
-
Mouse Mutations DIsrupting Somitogenesis and Vertebral Patterning
-
Moroto M., and Whittock N. (Eds), Springer
-
Kusumi K., Sewell W., and O'Brien M. Mouse Mutations DIsrupting Somitogenesis and Vertebral Patterning. In: Moroto M., and Whittock N. (Eds). Somitogenesis vol. 638 (2009), Springer 140-156
-
(2009)
Somitogenesis
, vol.638
, pp. 140-156
-
-
Kusumi, K.1
Sewell, W.2
O'Brien, M.3
-
24
-
-
0141891476
-
Carbon monoxide-induced axial skeletal dysmorphogenesis in the chick embryo
-
Alexander P.G., and Tuan R.S. Carbon monoxide-induced axial skeletal dysmorphogenesis in the chick embryo. Birth Defects Res A Clin Mol Teratol 67 (2003) 219-230
-
(2003)
Birth Defects Res A Clin Mol Teratol
, vol.67
, pp. 219-230
-
-
Alexander, P.G.1
Tuan, R.S.2
-
25
-
-
0033362086
-
A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3
-
Turnpenny P.D., Bulman M.P., Frayling T.M., Abu-Nasra T.K., Garrett C., Hattersley A.T., and Ellard S. A gene for autosomal recessive spondylocostal dysostosis maps to 19q13.1-q13.3. Am J Hum Genet 65 (1999) 175-182
-
(1999)
Am J Hum Genet
, vol.65
, pp. 175-182
-
-
Turnpenny, P.D.1
Bulman, M.P.2
Frayling, T.M.3
Abu-Nasra, T.K.4
Garrett, C.5
Hattersley, A.T.6
Ellard, S.7
-
26
-
-
17344368196
-
The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries
-
Kusumi K., Sun E.S., Kerrebrock A.W., Bronson R.T., Chi D.C., Bulotsky M.S., Spencer J.B., Birren B.W., Frankel W.N., and Lander E.S. The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries. Nat Genet 19 (1998) 274-278
-
(1998)
Nat Genet
, vol.19
, pp. 274-278
-
-
Kusumi, K.1
Sun, E.S.2
Kerrebrock, A.W.3
Bronson, R.T.4
Chi, D.C.5
Bulotsky, M.S.6
Spencer, J.B.7
Birren, B.W.8
Frankel, W.N.9
Lander, E.S.10
-
27
-
-
0034028904
-
Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis
-
Bulman M.P., Kusumi K., Frayling T.M., McKeown C., Garrett C., Lander E.S., Krumlauf R., Hattersley A.T., Ellard S., and Turnpenny P.D. Mutations in the human delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis. Nat Genet 24 (2000) 438-441
-
(2000)
Nat Genet
, vol.24
, pp. 438-441
-
-
Bulman, M.P.1
Kusumi, K.2
Frayling, T.M.3
McKeown, C.4
Garrett, C.5
Lander, E.S.6
Krumlauf, R.7
Hattersley, A.T.8
Ellard, S.9
Turnpenny, P.D.10
-
28
-
-
2442713782
-
Mutated MESP2 causes spondylocostal dysostosis in humans
-
Whittock N.V., Sparrow D.B., Wouters M.A., Sillence D., Ellard S., Dunwoodie S.L., and Turnpenny P.D. Mutated MESP2 causes spondylocostal dysostosis in humans. Am J Hum Genet 74 (2004) 1249-1254
-
(2004)
Am J Hum Genet
, vol.74
, pp. 1249-1254
-
-
Whittock, N.V.1
Sparrow, D.B.2
Wouters, M.A.3
Sillence, D.4
Ellard, S.5
Dunwoodie, S.L.6
Turnpenny, P.D.7
-
29
-
-
0030850751
-
Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation
-
Saga Y., Hata N., Koseki H., and Taketo M.M. Mesp2: a novel mouse gene expressed in the presegmented mesoderm and essential for segmentation initiation. Genes Dev 11 (1997) 1827-1839
-
(1997)
Genes Dev
, vol.11
, pp. 1827-1839
-
-
Saga, Y.1
Hata, N.2
Koseki, H.3
Taketo, M.M.4
-
30
-
-
19644371990
-
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
-
Morimoto M., Takahashi Y., Endo M., and Saga Y. The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature 435 (2005) 354-359
-
(2005)
Nature
, vol.435
, pp. 354-359
-
-
Morimoto, M.1
Takahashi, Y.2
Endo, M.3
Saga, Y.4
-
31
-
-
33644866845
-
Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression
-
Yasuhiko Y., Haraguchi S., Kitajima S., Takahashi Y., Kanno J., and Saga Y. Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression. Proc Natl Acad Sci U S A 103 (2006) 3651-3656
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3651-3656
-
-
Yasuhiko, Y.1
Haraguchi, S.2
Kitajima, S.3
Takahashi, Y.4
Kanno, J.5
Saga, Y.6
-
32
-
-
44449135947
-
Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
-
This study shows that the mutation in MESP2 causes the congenital vertebral disorder, spondylothoracic dysostosis. This is interesting as the mutation in MESP2 also causes the related, but distinct, spondylocostal dysostosis. It is unclear, how what appear to be equal deficiencies in MESP2 transcriptional activity in vitro, can cause these distinct vertebral anomalies in humans.
-
Cornier A.S., Staehling-Hampton K., Delventhal K.M., Saga Y., Caubet J.F., Sasaki N., Ellard S., Young E., Ramirez N., Carlo S.E., et al. Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome. Am J Hum Genet 82 (2008) 1334-1341. This study shows that the mutation in MESP2 causes the congenital vertebral disorder, spondylothoracic dysostosis. This is interesting as the mutation in MESP2 also causes the related, but distinct, spondylocostal dysostosis. It is unclear, how what appear to be equal deficiencies in MESP2 transcriptional activity in vitro, can cause these distinct vertebral anomalies in humans.
-
(2008)
Am J Hum Genet
, vol.82
, pp. 1334-1341
-
-
Cornier, A.S.1
Staehling-Hampton, K.2
Delventhal, K.M.3
Saga, Y.4
Caubet, J.F.5
Sasaki, N.6
Ellard, S.7
Young, E.8
Ramirez, N.9
Carlo, S.E.10
-
33
-
-
29244458644
-
Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype
-
This study shows that mutation of LFNG, a component of the Notch signalling pathway, causes the congenital vertebral disorder, spondylocostal dysostosis. It also shows that the single amino acid change in LFNG leads to its loss of activity in Notch signalling, and that this is because of the abrogation of its glycosyltransferase activity.
-
Sparrow D.B., Chapman G., Wouters M.A., Whittock N.V., Ellard S., Fatkin D., Turnpenny P.D., Kusumi K., Sillence D., and Dunwoodie S.L. Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. Am J Hum Genet 78 (2006) 28-37. This study shows that mutation of LFNG, a component of the Notch signalling pathway, causes the congenital vertebral disorder, spondylocostal dysostosis. It also shows that the single amino acid change in LFNG leads to its loss of activity in Notch signalling, and that this is because of the abrogation of its glycosyltransferase activity.
-
(2006)
Am J Hum Genet
, vol.78
, pp. 28-37
-
-
Sparrow, D.B.1
Chapman, G.2
Wouters, M.A.3
Whittock, N.V.4
Ellard, S.5
Fatkin, D.6
Turnpenny, P.D.7
Kusumi, K.8
Sillence, D.9
Dunwoodie, S.L.10
-
34
-
-
0032560814
-
lunatic fringe is an essential mediator of somite segmentation and patterning
-
Evrard Y.A., Lun Y., Aulehla A., Gan L., and Johnson R.L. lunatic fringe is an essential mediator of somite segmentation and patterning. Nature 394 (1998) 377-381
-
(1998)
Nature
, vol.394
, pp. 377-381
-
-
Evrard, Y.A.1
Lun, Y.2
Aulehla, A.3
Gan, L.4
Johnson, R.L.5
-
35
-
-
0032560766
-
Defects in somite formation in lunatic fringe-deficient mice
-
Zhang N., and Gridley T. Defects in somite formation in lunatic fringe-deficient mice. Nature 394 (1998) 374-377
-
(1998)
Nature
, vol.394
, pp. 374-377
-
-
Zhang, N.1
Gridley, T.2
-
36
-
-
0036267319
-
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice
-
Zhang N., Norton C.R., and Gridley T. Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis 33 (2002) 21-28
-
(2002)
Genesis
, vol.33
, pp. 21-28
-
-
Zhang, N.1
Norton, C.R.2
Gridley, T.3
-
37
-
-
0242593940
-
Glycosyltransferase activity of fringe modulates Notch-Delta interactions
-
Bruckner K., Perez L., Clausen H., and Cohen S. Glycosyltransferase activity of fringe modulates Notch-Delta interactions. Nature 406 (2000) 411-415
-
(2000)
Nature
, vol.406
, pp. 411-415
-
-
Bruckner, K.1
Perez, L.2
Clausen, H.3
Cohen, S.4
-
38
-
-
0001395691
-
Fringe is a glycosyltransferase that modifies Notch
-
Moloney D.J., Panin V.M., Johnston S.H., Chen J., Shao L., Wilson R., Wang Y., Stanley P., Irvine K.D., Haltiwanger R.S., et al. Fringe is a glycosyltransferase that modifies Notch. Nature 406 (2000) 369-375
-
(2000)
Nature
, vol.406
, pp. 369-375
-
-
Moloney, D.J.1
Panin, V.M.2
Johnston, S.H.3
Chen, J.4
Shao, L.5
Wilson, R.6
Wang, Y.7
Stanley, P.8
Irvine, K.D.9
Haltiwanger, R.S.10
-
39
-
-
0034253589
-
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2
-
Hicks C., Johnston S.H., diSibio G., Collazo A., Vogt T.F., and Weinmaster G. Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nat Cell Biol 2 (2000) 515-520
-
(2000)
Nat Cell Biol
, vol.2
, pp. 515-520
-
-
Hicks, C.1
Johnston, S.H.2
diSibio, G.3
Collazo, A.4
Vogt, T.F.5
Weinmaster, G.6
-
40
-
-
12944255642
-
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1
-
Yang L.T., Nichols J.T., Yao C., Manilay J.O., Robey E.A., and Weinmaster G. Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Mol Biol Cell 16 (2005) 927-942
-
(2005)
Mol Biol Cell
, vol.16
, pp. 927-942
-
-
Yang, L.T.1
Nichols, J.T.2
Yao, C.3
Manilay, J.O.4
Robey, E.A.5
Weinmaster, G.6
-
41
-
-
0037448536
-
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock
-
Dale J.K., Maroto M., Dequeant M.L., Malapert P., McGrew M., and Pourquie O. Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock. Nature 421 (2003) 275-278
-
(2003)
Nature
, vol.421
, pp. 275-278
-
-
Dale, J.K.1
Maroto, M.2
Dequeant, M.L.3
Malapert, P.4
McGrew, M.5
Pourquie, O.6
-
42
-
-
0035887251
-
Dynamic expression and essential functions of Hes7 in somite segmentation
-
Bessho Y., Sakata R., Komatsu S., Shiota K., Yamada S., and Kageyama R. Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev 15 (2001) 2642-2647
-
(2001)
Genes Dev
, vol.15
, pp. 2642-2647
-
-
Bessho, Y.1
Sakata, R.2
Komatsu, S.3
Shiota, K.4
Yamada, S.5
Kageyama, R.6
-
43
-
-
56049123626
-
Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis
-
This study shows that mutation of HES7, a target of the Notch signalling pathway, causes the congenital vertebral disorder spondylocostal dysostosis. It also shows that the single amino acid change in HES7 leads to a loss of its transcriptional repressive activity.
-
Sparrow D.B., Guillen-Navarro E., Fatkin D., and Dunwoodie S.L. Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis. Hum Mol Genet 17 (2008) 3761-3766. This study shows that mutation of HES7, a target of the Notch signalling pathway, causes the congenital vertebral disorder spondylocostal dysostosis. It also shows that the single amino acid change in HES7 leads to a loss of its transcriptional repressive activity.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3761-3766
-
-
Sparrow, D.B.1
Guillen-Navarro, E.2
Fatkin, D.3
Dunwoodie, S.L.4
-
44
-
-
0035065732
-
Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
-
Bessho Y., Miyoshi G., Sakata R., and Kageyama R. Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells 6 (2001) 175-185
-
(2001)
Genes Cells
, vol.6
, pp. 175-185
-
-
Bessho, Y.1
Miyoshi, G.2
Sakata, R.3
Kageyama, R.4
-
45
-
-
30944454348
-
Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
-
Chen J., Kang L., and Zhang N. Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis. Genesis 43 (2005) 196-204
-
(2005)
Genesis
, vol.43
, pp. 196-204
-
-
Chen, J.1
Kang, L.2
Zhang, N.3
-
46
-
-
3042842911
-
Instability of Hes7 protein is crucial for the somite segmentation clock
-
Hirata H., Bessho Y., Kokubu H., Masamizu Y., Yamada S., Lewis J., and Kageyama R. Instability of Hes7 protein is crucial for the somite segmentation clock. Nat Genet 36 (2004) 750-754
-
(2004)
Nat Genet
, vol.36
, pp. 750-754
-
-
Hirata, H.1
Bessho, Y.2
Kokubu, H.3
Masamizu, Y.4
Yamada, S.5
Lewis, J.6
Kageyama, R.7
-
47
-
-
0032403190
-
Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region
-
Kurooka H., Kuroda K., and Honjo T. Roles of the ankyrin repeats and C-terminal region of the mouse notch1 intracellular region. Nucleic Acids Res 26 (1998) 5448-5455
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 5448-5455
-
-
Kurooka, H.1
Kuroda, K.2
Honjo, T.3
-
48
-
-
0035929669
-
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
-
Oberg C., Li J., Pauley A., Wolf E., Gurney M., and Lendahl U. The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 276 (2001) 35847-35853
-
(2001)
J Biol Chem
, vol.276
, pp. 35847-35853
-
-
Oberg, C.1
Li, J.2
Pauley, A.3
Wolf, E.4
Gurney, M.5
Lendahl, U.6
-
49
-
-
0029583607
-
Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H)
-
Tamura K., Taniguchi Y., Minoguchi S., Sakai T., Tun T., Furukawa T., and Honjo T. Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H). Curr Biol 5 (1995) 1416-1423
-
(1995)
Curr Biol
, vol.5
, pp. 1416-1423
-
-
Tamura, K.1
Taniguchi, Y.2
Minoguchi, S.3
Sakai, T.4
Tun, T.5
Furukawa, T.6
Honjo, T.7
-
50
-
-
33947241465
-
SnapShot: notch signaling pathway
-
Ilagan M.X., and Kopan R. SnapShot: notch signaling pathway. Cell 128 (2007) 1246
-
(2007)
Cell
, vol.128
, pp. 1246
-
-
Ilagan, M.X.1
Kopan, R.2
-
51
-
-
0036065035
-
Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis
-
Cole S.E., Levorse J.M., Tilghman S.M., and Vogt T.F. Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. Dev Cell 3 (2002) 75-84
-
(2002)
Dev Cell
, vol.3
, pp. 75-84
-
-
Cole, S.E.1
Levorse, J.M.2
Tilghman, S.M.3
Vogt, T.F.4
-
52
-
-
0036065333
-
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling
-
Morales A.V., Yasuda Y., and Ish-Horowicz D. Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling. Dev Cell 3 (2002) 63-74
-
(2002)
Dev Cell
, vol.3
, pp. 63-74
-
-
Morales, A.V.1
Yasuda, Y.2
Ish-Horowicz, D.3
-
53
-
-
33746452268
-
Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2
-
Nakajima Y., Morimoto M., Takahashi Y., Koseki H., and Saga Y. Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. Development 133 (2006) 2517-2525
-
(2006)
Development
, vol.133
, pp. 2517-2525
-
-
Nakajima, Y.1
Morimoto, M.2
Takahashi, Y.3
Koseki, H.4
Saga, Y.5
-
54
-
-
0141504149
-
Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis
-
Barrios A., Poole R.J., Durbin L., Brennan C., Holder N., and Wilson S.W. Eph/Ephrin signaling regulates the mesenchymal-to-epithelial transition of the paraxial mesoderm during somite morphogenesis. Curr Biol 13 (2003) 1571-1582
-
(2003)
Curr Biol
, vol.13
, pp. 1571-1582
-
-
Barrios, A.1
Poole, R.J.2
Durbin, L.3
Brennan, C.4
Holder, N.5
Wilson, S.W.6
-
55
-
-
13144259630
-
EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract
-
Dottori M., Hartley L., Galea M., Paxinos G., Polizzotto M., Kilpatrick T., Bartlett P.F., Murphy M., Kontgen F., and Boyd A.W. EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. Proc Natl Acad Sci U S A 95 (1998) 13248-13253
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 13248-13253
-
-
Dottori, M.1
Hartley, L.2
Galea, M.3
Paxinos, G.4
Polizzotto, M.5
Kilpatrick, T.6
Bartlett, P.F.7
Murphy, M.8
Kontgen, F.9
Boyd, A.W.10
-
56
-
-
0035312946
-
Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control
-
Kullander K., Croll S.D., Zimmer M., Pan L., McClain J., Hughes V., Zabski S., DeChiara T.M., Klein R., Yancopoulos G.D., et al. Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control. Genes Dev 15 (2001) 877-888
-
(2001)
Genes Dev
, vol.15
, pp. 877-888
-
-
Kullander, K.1
Croll, S.D.2
Zimmer, M.3
Pan, L.4
McClain, J.5
Hughes, V.6
Zabski, S.7
DeChiara, T.M.8
Klein, R.9
Yancopoulos, G.D.10
-
57
-
-
50649117174
-
Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis
-
Oginuma M., Niwa Y., Chapman D.L., and Saga Y. Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis. Development 135 (2008) 2555-2562
-
(2008)
Development
, vol.135
, pp. 2555-2562
-
-
Oginuma, M.1
Niwa, Y.2
Chapman, D.L.3
Saga, Y.4
-
58
-
-
0038046204
-
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
-
Bessho Y., Hirata H., Masamizu Y., and Kageyama R. Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. Genes Dev 17 (2003) 1451-1456
-
(2003)
Genes Dev
, vol.17
, pp. 1451-1456
-
-
Bessho, Y.1
Hirata, H.2
Masamizu, Y.3
Kageyama, R.4
|