Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to Notch signaling

Developmental Cell

Volumn 3, Issue 1, 2002, Pages 63-74

  Morales, Aixa V ^a   Yasuda, Yuko ^a   Ish Horowicz, David ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; NOTCH RECEPTOR; PROTEIN LFNG; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; EMBRYO SEGMENTATION; ENHANCER REGION; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE REPRESSION; GENETIC MODEL; GENETIC TRANSCRIPTION; MESODERM; MOLECULAR CLOCK; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATOR; PROMOTER REGION; SIGNAL TRANSDUCTION; SOMITE; TRANSCRIPTION INITIATION;

MURINAE; VERTEBRATA;

EID: 0036065333     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1534-5807(02)00211-3     Document Type: Article

References (43)

1. Dynamic expression of lunatic fringe suggests a link between Notch signaling and an autonomous cellular oscillator driving somite segmentation
2. Hes7: A bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm
3. Dynamic expression and essential functions of Hes7 in somite segmentation
4. Transient and restricted expression during mouse embryogenesis of DII1 a murine gene closely related to Drosophila Delta
5. Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis
6. Notch1 is required for the coordinate segmentation of somites
7. A clock and wavefront model for control of the number of repeated structures during animal morphogenesis
8. Molecular targets of vertebrate segmentation: Two mechanisms control segmental expression of Xenopus hairy2 during somite formation
9. Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse
10. FGF signaling controls somite boundary position and regulates segmentation clock control of spatiotemporal Hox gene activation
11. Mouse DII3: A novel divergent Delta gene which may complement the function of other Delta homologues during early pattern formation in the mouse embryo
12. Mapping of the human Lunatic Fringe (LFNG) gene to 7p22 and Manic Fringe (MFNG) to 22q12
13. Lunatic fringe is an essential mediator of somite segmentation and patterning
14. Waves of mouse Lunatic fringe expression in four-hour cycles at two-hour intervals, precede somite boundary formation
15. Somitogenesis
16. A series of normal stages in the development of the chick
17. Expression of a Delta homologue in prospective neurons of the chick
18. Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activity
19. Maintenance of somite borders in mice requires the Delta homologue DII1
20. Signalling downstream of activated mammalian Notch
21. Periodic repression of Notch pathway genes governs the segmentation of Xenopus embryos
22. Notch signalling and the synchronization of the somite segmentation clock
23. A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway
24. Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm
25. Helix-loop-helix factors in growth and differentiation of the vertebrate nervous system
26. The mouse pudgy mutation disrupts Delta homologue DII3 and initiation of early somite boundaries
27. Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors
28. A clock-and-wavefront model simulates the observed pattern of c-hairy1 expression during somitogenesis
29. A molecular clock involved in somite segmentation
30. The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos
31. Expression of Delta 1 and Serrate1 (Jagged1) in the mouse inner ear
32. HRT1, HRT2 and HRT3: A new subclass of bHLH transcription factors marking specific cardiac, somitic, and pharyngeal arch segments
33. Disruption of the mouse RBP-J kappa gene results in early embryonic death
34. Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesis
35. Fringe modulates Notch-ligand interactions
36. A nomenclature for prospective somites and phases of cyclic gene expression in the presomitic mesoderm
37. The making of the somite: Molecular events in vertebrate segmentation
38. Fgf/MAPK signalling is a crucial positional cue in somite boundary formation
39. Progression of the cell cycle through mitosis leads to abortion of nascent transcripts
40. Mesp2 initiates somite segmentation through the Notch signalling pathway
41. Mechanisms of developmental control of transcription in the murine α- and β-globin loci
42. The regulation of myogenin gene expression during the embryonic development of the mouse
43. Defects in somite formation in lunatic fringe-deficient mice