Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells

Journal of Clinical Investigation

Volumn 119, Issue 8, 2009, Pages 2343-2358

  Álvarez Díaz, Silvia ^a   Valle, Noelia ^a   García, José Miguel ^b   Peña, Cristina ^b   Freije, José M P ^c   Quesada, Víctor ^c   Astudillo, Aurora ^d   Bonilla, Félix ^b   López Otín, Carlos ^c   Muñoz, Alberto ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^c DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^d HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CALCITRIOL; CATHEPSIN L; COMPLEMENTARY DNA; CYCLOHEXIMIDE; CYSTATIN; CYSTATIN D; CYSTEINE PROTEINASE; DACTINOMYCIN; DNA; RECOMBINANT PROTEIN; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; UVOMORULIN; VITAMIN D RECEPTOR; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN HCT116; COLON CANCER; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CST5 GENE; DNA CONTENT; FEMALE; FLOW CYTOMETRY; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR BINDING; TUMOR GROWTH; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT; WESTERN BLOTTING;

EID: 68849107323     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37205     Document Type: Article

References (45)

1. Deeb, K.K., Trump, D.L., and Johnson, C.S. 2007. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat. Rev. Cancer. 7:684-700.
2. Gorham, E.D., et al. 2007. Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. Am. J. Prev. Med. 32:210-216.
3. Lappe, J.M., Travers-Gustafson, D., Davies, K.M., Recker, R.R., and Heaney, R.P. 2007. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am. J. Clin. Nutr. 85:1586-1591.
4. Ng, K., et al. 2008. Circulating 25-hydroxyvitamin D levels and survival in patients with colorectal cancer. J. Clin. Oncol. 26:2984-2991.
5. Ordóñez-Morán, P., et al. 2005. Vitamin D and cancer: an update of in vitro and in vivo data. Front. Biosci. 10:2723-2749.
6. Campbell, M.J., and Adorini, L. 2006. The vitamin D receptor as a therapeutic target. Expert Opin. Ther. Targets. 10:735-748.
7. Eelen, G., et al. 2007. Mechanism and potential of the growth-inhibitory actions of vitamin D and analogs. Curr. Med. Chem. 14:1893-1910.
8. 3 and its analog EB1089 under growth-inhibitory conditions in squamous carcinoma cells. Mol. Endocrinol. 15:1127-1139.
9. 3 in human colon cancer cells. Cancer Res. 63:7799-7806.
10. Swami, S., Raghavachari, N., Muller, U.R., Bao, Y.P., and Feldman, D. 2003. Vitamin D growth inhibition of breast cancer cells: gene expression patterns assessed by cDNA microarray. Breast Cancer Res. Treat. 80:49-62.
11. Wood, R.J., Tchack, L., Angelo, G., Pratt, R.E., and Sonna, L.A. 2004. DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol. Genomics. 17:122-129.
12. 3 promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of β-catenin signaling. J. Cell Biol. 154:369-387.
13. Shah, S., et al. 2006. The molecular basis of vitamin D receptor and beta-catenin crossregulation. Mol. Cell. 21:799-809.
14. Zhang, J., et al. 2004. Cystatin M: a novel candidate tumor suppressor gene for breast cancer. Cancer Res. 64:6957-6964.
15. Freije, J.P., et al. 1991. Structure and expression of the gene encoding cystatin D, a novel human cysteine proteinase inhibitor. J. Biol. Chem. 266:20538-20543.
16. Balbin, M., et al. 1994. Structural and functional characterization of two allelic variants of human cystatin D sharing a characteristic inhibition spectrum against mammalian cysteine proteinases. J. Biol. Chem. 269:23156-23162.
17. Gocheva, V., et al. 2006. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 20:543-556.
18. Gocheva, V., and Joyce, J.A. 2007. Cysteine cathepsins and the cutting edge of cancer invasion. Cell Cycle. 6:60-64.
19. Goulet, B., et al. 2007. Increased expression and activity of nuclear cathepsin L in cancer cells suggests a novel mechanism of cell transformation. Mol. Cancer Res. 5:899-907.
20. Pálmer, H.G., et al. 2004. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nat. Med. 10:917-919.
21. Clevers, H. 2006. Wnt/beta-catenin signaling in development and disease. Cell. 127:469-480.
22. Segditsas, S., and Tomlinson, I. 2006. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene. 25:7531-7537.
23. Peña, C., et al. 2005. E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum. Mol. Genet. 14:3361-3370.
24. Garland, C.F., and Garland, F.C. 2005. Do sunlight and vitamin D reduce the likelihood of colon cancer? Int. J. Epidemiol. 35:217-220.
25. 3 receptors in normal and malignant human colorectal tissues. Cancer Lett. 86:67-73.
26. Cross, H.S., et al. 1996. Vitamin D receptor and cytokeratin expression may be progression indicators in human colon cancer. Anticancer Res. 16:2333-2337.
27. Evans, S.R., et al. 1998. Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer. Clin. Cancer Res. 4:1591-1595.
28. Joyce, J.A., and Hanahan, D. 2004. Multiple roles for cysteine cathepsins in cancer. Cell Cycle. 3:1516-1619.
29. Kuester, D., Lippert, H., Roessner, A., and Krueger, S. 2008. The cathepsin family and their role in colorectal cancer. Pathol. Res. Pract. 204:491-500.
30. Sokol, J.P., and Schiemann, W.P. 2004. Cystatin C antagonizes transforming growth factor beta signaling in normal and cancer cells. Mol. Cancer Res. 2:183-195.
31. Shridhar, R., et al. 2004. Cystatin M suppresses the malignant phenotype of human MDA-MB-435S cells. Oncogene. 23:2206-2215.
32. Shachaf, C.M., et al. 2008. Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Cancer Res. 68:5132-5142.
33. Peinado, H., Olmeda, D., and Cano, A. 2007. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer. 7:415-428.
34. Onder, T.T., et al. 2008. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 68:3645-3654.
35. Mani, S.A., et al. 2008. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704-715.
36. Freije, J.P., et al. 1993. Human cystatin D. cDNA cloning, characterization of the Escherichia coli expressed inhibitor, and identification of the native protein in saliva. J. Biol. Chem. 268:15737-15744.
37. Schagdarsurengin, U., Pfeifer, G.P., and Dammann, R. 2007. Frequent epigenetic inactivation of cystatin M in breast carcinoma. Oncogene. 26:3089-3094.
38. Stetler-Stevenson, W.G. 2008. The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2. Cancer Metastasis Rev. 27:57-66.
39. Takahashi, H., et al. 2003. 1,25-dihydroxyvitamin D(3) increases human cystatin A expression by inhibiting the Raf-1/MEK1/ERK signaling pathway of keratinocytes. Arch. Dermatol. Res. 295:80-87.
40. Wang, T.T., et al. 2005. Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol. Endocrinol. 19:2685-2695.
41. -/- colon carcinoma. Science. 275:1784-1787.
42. Lee, T.C., and Ziff, E.B. 1999. Mxi1 is a repressor of the c-Myc promoter and reverses activation by USF. J. Biol. Chem. 274:595-606.
43. Inubushi, T., Kakegawa, H., Kishino, Y., and Katunuma, N. 1994. Specific assay method for the activities of cathepsin L-type cysteine proteinases. J. Biochem. 116:282-284.
44. Ballestar, E., et al. 2003. Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J. 22:6335-6345.
45. Vandesompele, J., et al. 2002. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3:RESEARCH0034.