Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2

Molecular and Cellular Biology

Volumn 29, Issue 17, 2009, Pages 4864-4872

  Im, Seung Soon ^a   Hammond, Linda E ^a   Yousef, Leyla ^a   Nugas Selby, Cherryl ^a   Shin, Dong Ju ^a   Seo, Young Kyo ^a   Fong, Loren G ^b   Young, Stephen G ^b   Osborne, Timothy F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 2; ACYL COENZYME A; DNA; FATTY ACID; KETONE; MESSENGER RNA; PROTEIN P300; STEROL REGULATORY ELEMENT BINDING PROTEIN 1A; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOSOL; DIET RESTRICTION; DIMERIZATION; DNA BINDING; ENZYME ACTIVATION; GENE CONTROL; GENE EXPRESSION; HOMOZYGOSITY; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; MITOCHONDRION; MOUSE; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACETYL-COA CARBOXYLASE; ANIMALS; CELL LINE; DIET; ENZYME ACTIVATION; FATTY ACIDS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROARRAY ANALYSIS; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; PROTEIN ISOFORMS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

MUS;

EID: 68849091864     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00553-09     Document Type: Article

References (24)

1. Abu-Elheiga, L., M. M. Matzuk, K. A. Abo-Hashema, and S. J. Wakil. 2001. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 291:2613-2616.
2. Athanikar, J. N., H. B. Sanchez, and T. F. Osborne. 1997. Promoter selective transcriptional synergy mediated by SREBP and Sp1: a critical role for the Btd domain of Sp1. Mol. Cell. Biol. 17:5193-5200.
3. Baldi, P., and A. D. Long. 2001. A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics. 17:509-519.
4. Bennett, M. K., Y.-K. Seo, S. Datta, D.-J. Shin, and T. F. Osborne. 2008. Selective binding of SREBP isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver. J. Biol. Chem. 283:15628-15637.
5. Browning, J. D., and J. D. Horton. 2004. Molecular mediators of hepatic steatosis and liver injury. J. Clin. Investig. 114:147-152.
6. Chandler, C. E., D. E. Wilder, J. L. Pettini, Y. E. Savoy, S. F. Petras, G. Chang, J. Vincent, and H. J. Harwood, Jr. 2003. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J. Lipid Res. 44:1887-1901.
7. Datta, S., and T. F. Osborne. 2005. Activation domains from both monomers contribute to transcriptional stimulation by SREBP dimers. J. Biol. Chem. 280:3338-3345.
8. Datta, S., L. Wang, D. D. Moore, and T. F. Osborne. 2006. Regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase promoter by nuclear receptors liver receptor homologue-1 and small heterodimer partner: a mechanism for differential regulation of cholesterol synthesis and uptake. J. Biol. Chem. 281:807-812.
9. Espenshade, P. J., and A. L. Hughes. 2007. Regulation of sterol synthesis in eukaryotes. Annu. Rev. Genet. 41:401-427.
10. Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Investig. 109:1125-1131.
11. Liang, G., J. Yang, J. D. Horton, R. E. Hammer, J. L. Goldstein, and M. S. Brown. 2002. Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c. J. Biol. Chem. 277:9520-9528.
12. Magaña, M. M., S.-H. Koo, H. C. Towle, and T. F. Osborne. 2000. Different sterol regulatory element binding protein-1 isoforms utilize distinct co-regulatory factors to activate the promoter for fatty acid synthase. J. Biol. Chem. 275:4726-4733.
13. Ogryzko, V. V., R. L. Schlitz, V. Russanova, B. H. Howard, and Y. Nakatani. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87:953-959.
14. Oh, S. Y., S. K. Park, J. W. Kim, Y. H. Ahn, S. W. Park, and K. S. Kim. 2003. Acetyl-CoA carboxylase beta gene is regulated by sterol regulatory elementbinding protein-1 in liver. J. Biol. Chem. 278:28410-28417.
15. Sanchez, H. B., L. Yieh, and T. F. Osborne. 1995. Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270:1161-1169.
16. Shimano, H., J. D. Horton, L. Shimomura, R. E. Hammer, M. S. Brown, and J. L. Goldstein. 1997. Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and cultured cells. J. Clin. Investig. 99:846-854.
17. Shimano, H., I. Shimomura, R. E. Hammer, J. Herz, M. S. Brown, J. L. Goldstein, and J. D. Horton. 1997. Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene. J. Clin. Investig. 100:2115-2124.
18. Shimomura, I., H. Shimano, J. D. Horton, J. L. Goldstein, and M. S. Brown. 1997. Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells. J. Clin. Investig. 99:838-845.
19. Stryke, D., M. Kawamoto, C. C. Huang, S. J. Johns, L. A. King, C. A. Harper, E. C. Meng, R. E. Lee, A. Yee, L. L'Italien, P. T. Chuang, S. G. Young, W. C. Skarnes, P. C. Babbitt, and T. E. Ferrin. 2003. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 31:278-281.
20. Toth, J. I., S. Datta, J. N. Athanikar, L. P. Freedman, and T. F. Osborne. 2004. Selective coactivator interactions in gene activation by SREBP-1a and-1c. Mol. Cell. Biol. 24:8288-8300.
21. Townley, D. J., B. J. Avery, B. Rosen, and W. C. Skarnes. 1997. Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genome Res. 7:293-298.
22. Wakil, S. J., and L. A. Abu-Elheiga. 2008. Fatty acid metabolism: target for metabolic syndrome. J. Lipid Res. 50(Suppl.):S138-S143.
23. Yang, X.-J., V. V. Ogryzko, J.-I. Nishikawa, B. H. Howard, and Y. Nakatani. 1996. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
24. Yieh, L., H. B. Sanchez, and T. F. Osborne. 1995. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein-1 of low-density lipoprotein receptor promoter. Proc. Natl. Acad. Sci. USA 92:6102-6106.