Promoter selective transcriptional synergy mediated by sterol regulatory element binding protein and Sp1: A critical role for the Btd domain of Sp1

Molecular and Cellular Biology

Volumn 17, Issue 9, 1997, Pages 5193-5200

  Athanikar, Jyoti N ^a   Sanchez, Hugo B ^a,b   Osborne, Timothy F ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID SYNTHASE; LOW DENSITY LIPOPROTEIN RECEPTOR; REGULATOR PROTEIN; STEROL; TRANSCRIPTION FACTOR SP1;

ANIMAL CELL; ARTICLE; BINDING SITE; DROSOPHILA; GENE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN DOMAIN; TRANSCRIPTION REGULATION;

ANIMALIA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0030745393     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.9.5193     Document Type: Article

References (44)

1. Bennett, M. K., J. M. Lopez, H. B. Sanchez, and T. F. Osborne. 1995. Sterol regulation of fatty acid synthase promoter: coordinate feedback regulation of two major lipid pathways. J. Biol. Chem. 270:25578-25583.
2. Briggs, M. R., C. Yokoyama, X. Wang, M. S. Brown, and J. L. Goldstein. 1993. Nuclear protein that binds sterol regulatory element of low density receptor promoter I: identification of the protein and delineation of its target nucleotide sequence. J. Biol. Chem. 268:14490-14496.
3. Brown, M. S., and J. L. Goldstein. 1997. The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89:331-340.
4. Chen, L. I., T. Nishinaka, K. Kwan, I. Kitabayashi, K. Yokoyama, Y.-H. Fu, S. Grunwald, and R. Chin. 1994. The retinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator. Mol. Cell. Biol. 14:4380-4389.
5. Courey, A. J., D. A. Holtzman, S. P. Jackson, and R. Tjian. 1989. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59:827-836.
6. Courey, A. J., and R. Tjian. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55:887-898.
7. Dawson, P. A., S. L. Hofmann, D. R. Van Der Westhuyzen, T. C. Sudhof, M. S. Brown, and J. L. Goldstein. 1988. Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-basepair sequence adjacent to binding site for transcription factor Sp1. J. Biol. Chem. 263:3372-3379.
8. Dynan, W. S., and R. T. Tjian. 1983. The promoter specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. Cell 35:79-87.
9. Goldstein, J., and M. Brown. 1990. Regulation of the mevalonate pathway. Nature 343:425-430.
10. Hagen, G., J. Dennig, A. Preib, M. Beato, and G. Suske. 1995. Functional analyses of the transcription factor Sp4 reveal properties distinct from Sp1 and Sp3. J. Biol. Chem. 270:24989-24994.
11. Hagen, G., S. Muller, M. Beato, and G. Suske. 1994. Sp1-mediated transcriptional activation is repressed by Sp3. EMBO J. 13:3843-3851.
12. Hua, X., J. Sakai, Y. K. Ho, J. L. Goldstein, and M. S. Brown. 1995. Hairpin orientation of sterol regulatory element-binding protein-2 in cell membranes as determined by protease protection. J. Biol. Chem. 270:29422-29427.
13. Hua, X., J. Wu, J. L. Goldstein, M. S. Brown, and H. H. Hobbs. 1995. Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBPF1) and localization of SREBPF1 and SREBPF2 to chromosomes 17p11.2 and 22q13. Genomics 25:667-673.
14. Hua, X., C. Yokoyama, J. Wu, M. R. Briggs, M. S. Brown, J. L. Goldstein, and X. Wang. 1993. SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element Proc. Natl. Acad. Sci. USA 90:11603-11607.
15. Jackson, S. M., J. Ericsson, J. E. Metherall, and P. A. Edwards. 1996. A role for sterol regulatory element binding protein in the regulation of farnesyl diphosphate synthase and in the control of cellular levels of cholesterol and triglyceride: evidence from sterol regulation-defective cells. J. Lipid Res. 37:1712-1721.
16. Jackson, S. M., J. Ericsson, T. F. Osborne, and P. A. Edwards. 1995. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. J. Biol. Chem. 270:21445-21448.
17. Jonat, C., H. J. Rahmsdorf, K.-K. Park, A. C. B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and antiinflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell 62: 1189-1204.
18. Kadonaga, J. T., K. A. Jones, and R. Tjian. 1986. Promoter-specific activation of RNA polymerase II transcription by Sp1. Trends Biochem. Sci. 11:20-23.
19. Kim, J. B., and B. M. Spiegelman. 1996. ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism. Genes Dev. 10:1096-1107.
20. Kingsley, C., and A. Winoto. 1992. Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol. 12:4251-4261.
21. Lopez, J. M., M. K. Bennett, H. B. Sanchez, J. M. Rosenfeld, and T. F. Osborne. 1996. Sterol regulation of acetyl CoA carboxylase: a mechanism for coordinate control of cellular lipid. Proc. Natl. Acad. Sci. USA 93:1049-1053.
22. Magaña, M. M., S. S. Lin, K. A. Dooley, and T. F. Osborne. Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins. J. Lipid Res. in press.
23. Magaña, M. M., and T. F. Osborne. 1996. Two tandem binding sites for sterol regulatory element binding proteins are required for sterol regulation of fatty acid synthase promoter. J. Biol. Chem. 271:32689-32694.
24. Majello, B., P. De Luca, and L. Lania. 1997. Sp3 is a bifunctional transcription regulator with modular independent activation and repression domains. J. Biol. Chem. 272:4021-4026.
25. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
26. Murata, Y., H. G. Kim, K. T. Rogers, A. J. Udvadia, and J. M. Horowitz. 1994. Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain. J. Biol. Chem. 269:20674-20681.
27. Nishio, Y., H. Asshiki, T. Kishimoto, and S. Akira. 1993. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat α1-acid glycoprotein via direct protein-protein interaction. Mol. Cell. Biol. 13:1854-1862.
28. Osborne, T. F. 1995. Transcriptional control mechanisms in the regulation of cholesterol balance. Crit. Rev. Eukaryotic Gene. Expression 5:317-335.
29. Pascal, E., and R. Tjian. 1991. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev. 5:1646-1656.
30. Perkins, N. D., A. B. Agranoff, E. Pascal, and G. Nabel. 1994. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation. Mol. Cell. Biol. 14:6570-6583.
31. Sakai, J., E. A. Duncan, R. B. Rawson, X. Hua, M. S. Brown, and J. L. Goldstein. 1996. Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment. Cell 85:1037-1046.
32. Sanchez, H. B., L. Yieh, and T. F. Osborne. 1995. Cooperation by SREBP and Sp1 in sterol regulation of low density lipoprotein receptor gene. J. Biol. Chem. 270:1161-1169.
33. Sheng, Z., H. Otani, M. S. Brown, and J. L. Goldstein. 1995. Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver. Proc. Natl. Acad. Sci. USA 92:935-938.
34. Shimano, H., J. D. Horton, R. E. Hammer, I. Shimomura, M. S. Brown, and J. L. Goldstein. 1996. Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a, J. Clin. Invest. 98:1575-1584.
35. Smith, J. R., T. F. Osborne, J. L. Goldstein, and M. S. Brown. 1990. Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J. Biol. Chem. 265:2306-2310.
36. Sudhof, T., D. Van der Westhuyzen, J. Goldstein, M. Brown, and D. Russell. 1987. Sterol dependent repression of low density lipoprotein receptor promoter mediated by 16 base-pair sequence adjacent to binding site for transcription factor Sp1. J. Biol. Chem. 262:10773-10779.
37. Tontonoz, P., J. B. Kim, R. A. Graves, and B. M. Spiegelman. 1993. ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation. Mol. Cell. Biol. 13:4753-4759.
38. Udvadia, A. J., D. J. Templeton, and J. M. Horowitz. 1995. Functional interactions between the retinoblastoma (RB) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. Proc. Natl. Acad. Sci. USA 92:3953-3957.
39. Wagner, S., and M. Green. 1993. HTLV-1 Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization. Science 262:395-399.
40. Wang, X., M. R. Briggs, X. Hua, C. Yokohama, J. L. Goldstein, and M. S. Brown. 1993. Nuclear protein that binds sterol regulatory element of low density receptor promoter II: purification and characterization. J. Biol. Chem. 268:14497-14504.
41. Wang, X., R. Sato, M. S. Brown, X. Hua, and J. L. Goldstein. 1994. SREBP-1, a membrane-bound transcription factor released by sterol regulated proteolysis. Cell 77:53-62.
42. Wimmer, E. A., H. Jackle, C. Pfeife, and S. M. Cohen. 1993. A drosophila homologue of human Sp1 is a head-specific segmentation gene. Nature 366:690-694.
43. Yieh, L., H. B. Sanchez, and T. F. Osborne. 1995. Domains of transcription factor Sp1 required for synergistic activation with sterol regulatory element binding protein-1 of low density lipoprotein receptor promoter. Proc. Natl. Acad. Sci. USA 92:6102-6106.
44. Yokoyama, C., X. Wang, M. R. Briggs, A. Admon, J. Wu, X. Hua, J. L. Goldstein, and M. S. Brown. 1993. SREBP-1, a basic-helix-loop-helix-zipper protein that controls transcription of the low density receptor gene. Cell 75:185-197.