Characterising drug release processes within controlled release dosage forms using the confocal laser scanning microscope

Journal of Controlled Release

Volumn 42, Issue 2, 1996, Pages 115-124

  Cutts, L S ^a   Hibberd, S ^a   Adler, J ^a   Davies, M C ^a   Melia, C D ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Confocal laser scanning microscopy; Diffusion; Dissolution; Drug release mechanism; Pellet

Indexed keywords

MINOCYCLINE;

ARTICLE; CONFOCAL LASER MICROSCOPY; DIFFUSION; DISSOLUTION; DRUG RELEASE; MATHEMATICAL MODEL; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE PREPARATION;

EID: 0030296096     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(96)01340-5     Document Type: Article

References (13)

1. [1] United States Pharmacopoeia XXII. Dissolution test for tablets and capsules, 1990, pp. 1578-1579.
2. [2] R. Wilding, C.D. Melia and K.A. Khan, Changes in drug distribution and internal structure of oral pellet systems during in vitro dissolution: cryogenic scanning electron microscopy and X-Ray microanalysis. Pharm. Technol. Int. 3.(10) (1991) 24-29.
3. [3] L.S. Cutts, R. Bowtell, I. Paterson-Stephens, M.C. Davis and C.D. Melia, Solute and water transport within the gel layer of hydrating HPMC tablets. Proc. Int. Symp. Control. Rel. Bioact. Mater. 22 (1995) 236-237.
4. [4] A.R. Rajabi-Siahboomi, R.W. Bowtell, P. Mansfield, M.C. Davies and C.D. Melia, Structure and behaviour in hydrophilic matrix sustained release dosage forms: 4. Studies of self-diffusion water mobility and diffusion coefficients in the gel layer of HPMC tablets using NMR imaging. Pharm. Research 13 (1996) 376-380.
5. [5] A.R. Rajabi-Siahboomi, R.W. Bowtell, P. Mansfield, A. Henderson, M.C. Davies and C.D. Melia, Structure and behaviour in hydrophilic matrix sustained release dosage forms: 2. NMR-imaging studies of the dimensional changes in the gel layer and core of HPMC matrices undergoing hydration. J. Control. Rel. 31 (1994) 121-128.
6. [6] G.M.R. Vandenbossche, P. Van Oostveldt and J.P. Remon, A fluorescence method for the determination of the molecular weight cut-off of alginate-polylysine microcapsules. J. Pharm. Pharmacol. 43 (1991) 275-277.
7. [7] J. Adler and C.D. Melia, Using a distance transform function in image processing. Micros. Anal. 41 (1994) 31-33.
8. [8] R.S. Harland, C. Dubernet, J.P. Benoît and N.A. Peppas, A model of dissolution - controlled, diffusional drug release from non-swellable polymeric microspheres. J. Control. Rel. 7 (1988) 207-215.
9. [9] J. Crank, The Mathematics of Diffusion, Clarendon Press, Oxford, 1975.
10. [10] D. Axelrod, D.E. Koppel, J. Schlessinger, E. Elson and W.W. Webb, Mobility measurement by analysis of fluorescence photobleaching recovery kinetics. Biophys. J. 16 (1976) 1055-1069.
11. [11] J.C.G. Blonk, A. Don, H. Van Aalst and J.J. Birmingham, Fluorescence photobleaching recovery in the confocal scanning light microscope. J. Micros. 169 (1993) 363-374.
12. [12] L. Blomquist and A. Hanngren, Fluorescence technique applied to whole body sections for distribution studies of tetracyclines. Biochem. Pharmacol. 15 (1965) 215-219.
13. [13] W.C. Barringer, W. Shultz, G.M. Sieger and R.A. Nash, Minocycline hydrochloride and its relationship to other tetracycline antibiotics. Am. J. Pharm. 146 (1974) 179-191.