Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10-hydroxycamptothecins

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 15, 2004, Pages 4003-4008

  He, Xungui ^a   Lu, Wei ^a   Jiang, Xiqun ^b   Cai, Junchao ^a   Zhang, Xiongwen ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

10 Hydroxycamptothecin; Antitumor; Camptothecin; Carbonate

Indexed keywords

10 HYDROXYCAMPTOTHECIN; 10 HYDROXYCAMPTOTHECIN 10,20 DIISOBUTYLCARBONATE; BUFFER; CAMPTOTHECIN DERIVATIVE; CARBONIC ACID DERIVATIVE; ESTERASE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL LINE; CONTROLLED STUDY; CYSTITIS; CYTOTOXICITY; DIARRHEA; DRUG EFFECT; DRUG HYDROLYSIS; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; LEUKEMIA CELL; LIVER; LUNG CANCER; MOUSE; NONHUMAN; PH; PLASMA; SARCOMA; SOLID TUMOR; WEIGHT REDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CAMPTOTHECIN; CARBONATES; CELL DIVISION; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; HUMANS; LACTONES; MICE; PRODRUGS; TIME FACTORS;

SUIDAE;

EID: 3042752527     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.06.003     Document Type: Article

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