N-[2-Chloro-9H-purin-6-yl]-N-cyclopropylglycylamino acids and derivatives: Synthesis, evaluation as a class of novel analgesics, and 3D QSAR analysis

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 17, 2009, Pages 6305-6310

  Zhao, Jinghua ^a   Kang, Guifeng ^a   Wang, Wei ^c   Zhao, Ming ^b   Zhang, Xiaoyi ^b   Lu, Chunbo ^d   Mao, Wei ^d   Chang, Heng Wei ^c   Ye, Weidong ^d   Peng, Shiqi ^a,b  

^a PEKING UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c C S Bio Company   (United States)

^d Zhejiang Medicine Co Ltd   (China)

Author keywords

3D QSAR; Analgesia; Substituted purine

Indexed keywords

ANALGESIC AGENT; BENZYL DERIVATIVE; CHLORINE DERIVATIVE; CYCLOPROPANE DERIVATIVE; ESTER DERIVATIVE; GLYCINE DERIVATIVE; MORPHINE; N (2 CHLORO 9H PURIN 6 YL) N CYCLOPROPYLGLYCYLAMINO ACID; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; MOUSE; NONHUMAN; PAIN THRESHOLD; QUANTITATIVE STRUCTURE ACTIVITY RELATION; QUANTUM YIELD; REACTION ANALYSIS; TAIL FLICK TEST;

AMINO ACIDS; ANALGESICS; ANIMALS; MICE; MOLECULAR CONFORMATION; PAIN MEASUREMENT; PURINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

MUS;

EID: 68649102555     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.07.035     Document Type: Article

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