Synthesis of (nor)tropeine (di)esters and allosteric modulation of glycine receptor binding

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 4, 2008, Pages 2086-2092

  Maksay, Gábor ^a   Nemes, Péter ^b   Vincze, Zoltán ^b   Bíró, Timea ^a  

^a CHEMICAL RESEARCH CENTER   (Hungary)

^b SZENT ISTVÁN UNIVERSITY   (Hungary)

Author keywords

Glycine displacement; Glycine receptors; Ternary allosteric model; Tropeines

Indexed keywords

3ALPHA (3' PYRIDINECARBONYLOXY)NORTROPANE; 3ALPHA (3' PYRIDINECARBONYLOXY)TROPANE; 3ALPHA (6' CHLORO 3' PYRIDINECARBONYLOXY)TROPANE; 3ALPHA (HYDROXYDIPHENYLACETOXY) N ALLYLNORTROPANE; 3ALPHA FUMAROYL BISGRANATANE; 3ALPHA FUMAROYL BISTROPANE; 3ALPHA ISOPHTHALOYL BISTROPANE; 3ALPHA SUCCINYL BIS N ETHYLNORTROPANE; 3ALPHA TEREPHTHALOYL BISTROPANE; 3BETA (9' NORXANTENECARBONYLOXY)NORTROPANE; ESTER DERIVATIVE; GLYCINE; GLYCINE RECEPTOR; NORSCOPOLAMINE; NORTROPISETRON; STRYCHNINE; TRITIUM; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; NONHUMAN; RAT;

ALLOSTERIC SITE; ANIMALS; BINDING, COMPETITIVE; ESTERS; PROTEIN BINDING; RATS; RECEPTORS, GLYCINE; SPINAL CORD; STRYCHNINE; TROPANES;

RATTUS; STRYCHNOS TOXIFERA;

EID: 38949168475     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.10.097     Document Type: Article

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