Genetic loci that control the size of laser-induced choroidal neovascularization

FASEB Journal

Volumn 23, Issue 7, 2009, Pages 2235-2243

  Nakai, Kei ^a   Rogers, Michael S ^a   Baba, Takashi ^b   Funakoshi, Taisaku ^b   Birsner, Amy E ^a   Luyindula, Dema S ^a   D'Amato, Robert J ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b TOTTORI UNIVERSITY   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

BXD; QTL; Quantitative trait locus; Recombinant inbred

Indexed keywords

ACTIN BINDING PROTEIN; ADRENERGIC RECEPTOR; BASIC FIBROBLAST GROWTH FACTOR; BETA 1 ADRENERGIC RECEPTOR; COLONY STIMULATING FACTOR 2 RECEPTOR; COLONY STIMULATING FACTOR 2 RECEPTOR ALPHA; COLONY STIMULATING FACTOR RECEPTOR; GROWTH FACTOR; LIM PROTEIN; LIM PROTEIN 1; PHOSPHOLIPASE C; PHOSPHOLIPASE C BETA2; PROTEIN BCL 2; THROMBOSPONDIN; THROMBOSPONDIN 1; THROMBOSPONDIN 1 DELTA LIKE 4; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ARTICLE; BLINDNESS; CHROMOSOME 19; CHROMOSOME 2; CONTROLLED STUDY; CORNEA; CORNEA NEOVASCULARIZATION; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENETIC DIFFERENCE; GENETIC SUSCEPTIBILITY; INBRED STRAIN; LABORATORY TEST; LASER; MALE; MARKER GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SUBRETINAL NEOVASCULARIZATION; ANIMAL; CHROMOSOME; CHROMOSOME MAP; GENE; GENETIC PREDISPOSITION; GENETICS; MOUSE STRAIN; NEOVASCULARIZATION (PATHOLOGY);

ANIMALS; CHOROIDAL NEOVASCULARIZATION; CHROMOSOME MAPPING; CHROMOSOMES; GENES; GENETIC PREDISPOSITION TO DISEASE; LASERS; MICE; MICE, INBRED STRAINS; NEOVASCULARIZATION, PATHOLOGIC; QUANTITATIVE TRAIT LOCI;

EID: 68549125419     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-124321     Document Type: Article

References (84)

1. Rohan, R. M., Fernandez, A., Udagawa, T., Yuan, J., and D'Amato, R. J. (2000) Genetic heterogeneity of angiogenesis in mice. FASEB J. 14, 871-876
2. Rogers, M. S., Rohan, R. M., Birsner, A. E., and D'Amato, R. J. (2003) Genetic loci that control vascular endothelial growth factor-induced angiogenesis. FASEB J. 17, 2112-2114
3. Rogers, M. S., Rohan, R. M., Birsner, A. E., and D'Amato, R. J. (2004) Genetic loci that control the angiogenic response to basic fibroblast growth factor. FASEB J. 18, 1050-1059
4. Kvanta, A., Algvere, P. V., Berglin, L., and Seregard, S. (1996) Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor. Invest. Ophthalmol. Vis. Sci. 37, 1929-1934 (Pubitemid 26324159)
5. Ishibashi, T., Hata, Y., Yoshikawa, H., Nakagawa, K., Sueishi, K., and Inomata, H. (1997) Expression of vascular endothelial growth factor in experimental choroidal neovascularization. Graefes Arch. Clin. Exp. Ophthalmol. 235, 159-167 (Pubitemid 27129479)
6. Miyamoto, K., Khosrof, S., Bursell, S. E., Moromizato, Y., Aiello, L. P., Ogura, Y., and Adamis, A. P. (2000) Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am. J. Pathol. 156, 1733-1739 (Pubitemid 30646710)
7. Ishida, S., Usui, T., Yamashiro, K., Kaji, Y., Ahmed, E., Carrasquillo, K. G., Amano, S., Hida, T., Oguchi, Y., and Adamis, A. P. (2003) VEGF164 is proinflammatory in the diabetic retina. Invest. Ophthalmol. Vis. Sci. 44, 2155-2162
8. Martin, G., Schlunck, G., Hansen, L. L., and Agostini, H. T. (2004) Differential expression of angioregulatory factors in normal and CNV-derived human retinal pigment epithelium. Graefes Arch. Clin. Exp. Ophthalmol. 242, 321-326 (Pubitemid 38647606)
9. Penfold, P. L., Madigan, M. C., Gillies, M. C., and Provis, J. M. (2001) Immunological and aetiological aspects of macular degeneration. Prog. Retin. Eye Res. 20, 385-414
10. Oh, H., Takagi, H., Takagi, C., Suzuma, K., Otani, A., Ishida, K., Matsumura, M., Ogura, Y., and Honda, Y. (1999) The potential angiogenic role of macrophages in the formation of choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. 40, 1891-1898 (Pubitemid 29365148)
11. Tsutsumi, C., Sonoda, K. H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., and Ishibashi, T. (2003) The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J. Leukoc. Biol. 74, 25-32 (Pubitemid 38040433)
12. Sakurai, E., Anand, A., Ambati, B. K., van Rooijen, N., and Ambati, J. (2003) Macrophage depletion inhibits experimental choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 44, 3578-3585 (Pubitemid 36909798)
13. Krzystolik, M. G., Afshari, M. A., Adamis, A. P., Gaudreault, J., Gragoudas, E. S., Michaud, N. A., Li, W., Connolly, E., O'Neill, C. A., and Miller, J. W. (2002) Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338-346 (Pubitemid 34250056)
14. Amin, R., Puklin, J. E., and Frank, R. N. (1994) Growth factor localization in choroidal neovascular membranes of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 35, 3178-3188 (Pubitemid 24241356)
15. Edwards, A. O., Ritter, R., 3rd, Abel, K. J., Manning, A., Panhuysen, C., and Farrer, L. A. (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308, 421-424
16. Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., Smith, R. J., Silvestri, G., Russell, S. R., Klaver, C. C., Barbazetto, I., Chang, S., Yannuzzi, L. A., Barile, G. R., Merriam, J. C., Smith, R. T., Olsh, A. K., Bergeron, J., Zernant, J., Merriam, J. E., Gold, B., Dean, M., and Allikmets, R. (2005) A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc. Natl. Acad. Sci. U. S. A. 102, 7227-7232 (Pubitemid 40696361)
17. Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., Schnetz-Boutaud, N., Agarwal, A., Postel, E. A., and Pericak- Vance, M. A. (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419-421
18. Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J. Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., Bracken, M. B., Ferris, F. L., Ott, J., Barnstable, C., and Hoh, J. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389 (Pubitemid 40530070)
19. Zareparsi, S., Branham, K. E., Li, M., Shah, S., Klein, R. J., Ott, J., Hoh, J., Abecasis, G. R., and Swaroop, A. (2005) Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am. J. Hum. Genet. 77, 149-153 (Pubitemid 40848046)
20. Schultz, D. W., Klein, M. L., Humpert, A. J., Luzier, C. W., Persun, V., Schain, M., Mahan, A., Runckel, C., Cassera, M., Vittal, V., Doyle, T. M., Martin, T. M., Weleber, R. G., Francis, P. J., and Acott, T. S. (2003) Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. Hum. Mol. Genet. 12, 3315-3323 (Pubitemid 37541077)
21. Schmidt, S., Saunders, A. M., De La Paz, M. A., Postel, E. A., Heinis, R. M., Agarwal, A., Scott, W. K., Gilbert, J. R., McDowell, J. G., Bazyk, A., Gass, J. D., Haines, J. L., and Pericak-Vance, M. A. (2000) Association of the apolipoprotein E gene with age-related macular degeneration: possible effect modification by family history, age, and gender. Mol. Vis. 6, 287-293
22. Stone, E. M., Braun, T. A., Russell, S. R., Kuehn, M. H., Lotery, A. J., Moore, P. A., Eastman, C. G., Casavant, T. L., and Sheffield, V. C. (2004) Missense variations in the fibulin 5 gene and age-related macular degeneration. N. Engl. J. Med. 351, 346-353 (Pubitemid 38944403)
23. Zareparsi, S., Buraczynska, M., Branham, K. E., Shah, S., Eng, D., Li, M., Pawar, H., Yashar, B. M., Moroi, S. E., Lichter, P. R., Petty, H. R., Richards, J. E., Abecasis, G. R., Elner, V. M., and Swaroop, A. (2005) Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum. Mol. Genet. 14, 1449-1455 (Pubitemid 40834203)
24. Allikmets, R. (2000) Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium. Am. J. Hum. Genet. 67, 487-491
25. Hamdi, H. K., Reznik, J., Castellon, R., Atilano, S. R., Ong, J. M., Udar, N., Tavis, J. H., Aoki, A. M., Nesburn, A. B., Boyer, D. S., Small, K. W., Brown, D. J., and Kenney, M. C. (2002) Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. Biochem. Biophys. Res. Commun. 295, 668-672 (Pubitemid 34756901)
26. Tuo, J., Smith, B. C., Bojanowski, C. M., Meleth, A. D., Gery, I., Csaky, K. G., Chew, E. Y., and Chan, C. C. (2004) The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J. 18, 1297-1299 (Pubitemid 39561582)
27. Jakobsdottir, J., Conley, Y. P., Weeks, D. E., Mah, T. S., Ferrell, R. E., and Gorin, M. B. (2005) Susceptibility genes for age-related maculopathy on chromosome 10q26. Am. J. Hum. Genet. 77, 389-407 (Pubitemid 41192646)
28. Ennis, S., Jomary, C., Mullins, R., Cree, A., Chen, X., Macleod, A., Jones, S., Collins, A., Stone, E., and Lotery, A. (2008) Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Lancet 372, 1828-1834
29. Ryan, S. J. (1979) The development of an experimental model of subretinal neovascularization in disciform macular degeneration. Trans. Am. Ophthalmol. Soc. 77, 707-745 (Pubitemid 10072828)
30. Dobi, E. T., Puliafito, C. A., and Destro, M. (1989) A new model of experimental choroidal neovascularization in the rat. Arch. Ophthalmol. 107, 264-269 (Pubitemid 19055348)
31. Tobe, T., Ortega, S., Luna, J. D., Ozaki, H., Okamoto, N., Derevjanik, N. L., Vinores, S. A., Basilico, C., and Campochiaro, P. A. (1998) Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am. J. Pathol. 153, 1641-1646 (Pubitemid 28509922)
32. Zeng, Z. B., Weir, B. S., and Basten, C. J. (1994) Zmap - a QTL cartographer. In Proceedings of the 5th World Congress on Genetics Applied to Livestock Production: Computing Strategies and Software, Vol.22 (Smith, C., Gavora, J. S., Benkel, B., Chesnais, J., Fairfull, W., Gibson, J. P., Kennedy, B. W., and Burnside, E. B., eds) pp. 65- 66, Organizing Committee, 65th World Congress on Genetics Applied to Livestock Production, Guelph, ON, Canada
33. Blake, J. A., Richardson, J. E., Bult, C. J., Kadin, J. A., and Eppig, J. T. (2002) The nouse genome database (MGD): the model organism database for the laboratory mouse. Nucleic Acids Res. 30, 113-115 (Pubitemid 34679519)
34. Rogers, M. S., Birsner, A. E., and D'Amato, R. J. (2007) The mouse cornea micropocket angiogenesis assay. Nat. Protoc. 2, 2545-2550
35. Waterston, R. H., Lindblad-Toh, K., Birney, E., Rogers, J., Abril, J. F., Agarwal, P., Agarwala, R., Ainscough, R., Alexandersson, M., An, P., Antonarakis, S. E., Attwood, J., Baertsch, R., Bailey, J., Barlow, K., Beck, S., Berry, E., Birren, B., Bloom, T., Bork, P., Botcherby, M., Bray, N., Brent, M. R., Brown, D. G., Brown, S. D., Bult, C., Burton, J., Butler, J., Campbell, R. D., Carninci, P., Cawley, S., Chiaromonte, F., Chinwalla, A. T., Church, D. M., Clamp, M., Clee, C., Collins, F. S., Cook, L. L., Copley, R. R., Coulson, A., Couronne, O., Cuff, J., Curwen, V., Cutts, T., Daly, M., David, R., Davies, J., Delehaunty, K. D., Deri, J., Dermitzakis, E. T., Dewey, C., Dickens, N. J., Diekhans, M., Dodge, S., Dubchak, I., Dunn, D. M., Eddy, S. R., Elnitski, L., Emes, R. D., Eswara, P., Eyras, E., Felsenfeld, A., Fewell, G. A., Flicek, P., Foley, K., Frankel, W. N., Fulton, L. A., Fulton, R. S., Furey, T. S., Gage, D., Gibbs, R. A., Glusman, G., Gnerre, S., Goldman, N., Goodstadt, L., Grafham, D., Graves, T. A., Green, E. D., Gregory, S., Guigó , R., Guyer, M., Hardison, R. C., Haussler, D., Hayashizaki, Y., Hillier, L. W., Hinrichs, A., Hlavina, W., Holzer, T., Hsu, F., Hua, A., Hubbard, T., Hunt, A., Jackson, I., Jaffe, D. B., Johnson, L. S., Jones, M., Jones, T. A., Joy, A., Kamal, M., Karlsson, E. K., Karolchik, D., Kasprzyk, A., Kawai, J., Keibler, E., Kells, C., Kent, W. J., Kirby, A., Kolbe, D. L., Korf, I., Kucherlapati, R. S., Kulbokas, E. J., Kulp, D., Landers, T., Leger, J. P., Leonard, S., Letunic, I., Levine, R., Li, J., Li, M., Lloyd, C., Lucas, S., Ma, B., Maglott, D. R., Mardis, E. R., Matthews, L., Mauceli, E., Mayer, J. H., McCarthy, M., McCombie, W. R., McLaren, S., McLay, K., McPherson, J. D., Meldrim, J., Meredith, B., Mesirov, J. P., Miller, W., Miner, T. L., Mongin, E., Montgomery, K. T., Morgan, M., Mott, R., Mullikin, J. C., Muzny, D. M., Nash, W. E., Nelson, J. O., Nhan, M. N., Nicol, R., Ning, Z., Nusbaum, C., O'Connor, M. J., Okazaki, Y., Oliver, K., Overton-Larty, E., Pachter, L., Parra, G., Pepin, K. H., Peterson, J., Pevzner, P., Plumb, R., Pohl, C. S., Poliakov, A., Ponce, T. C., Ponting, C. P., Potter, S., Quail, M., Reymond, A., Roe, B. A., Roskin, K. M., Rubin, E. M., Rust, A. G., Santos, R., Sapojnikov, V., Schultz, B., Schultz, J., Schwartz, M. S., Schwartz, S., Scott, C., Seaman, S., Searle, S., Sharpe, T., Sheridan, A., Shownkeen, R., Sims, S., Singer, J. B., Slater, G., Smit, A., Smith, D. R., Spencer, B., Stabenau, A., Stange-Thomann, N., Sugnet, C., Suyama, M., Tesler, G., Thompson, J., Torrents, D., Trevaskis, E., Tromp, J., Ucla, C., Ureta-Vidal, A., Vinson, J. P., Von Niederhausern, A. C., Wade, C. M., Wall, M., Weber, R. J., Weiss, R. B., Wendl, M. C., West, A. P., Wetterstrand, K., Wheeler, R., Whelan, S., Wierzbowski, J., Willey, D., Williams, S., Wilson, R. K., Winter, E., Worley, K. C., Wyman, D., Yang, S., Yang, S. P., Zdobnov, E. M., Zody, M. C., and Lander, E. S. (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420, 520-562 (Pubitemid 35477048)
36. Lander, E. S., and Botstein, D. (1989) Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121, 185-199
37. Zeng, Z. B. (1994) Precision mapping of quantitative trait loci. Genetics 136, 1457-1468 (Pubitemid 24097872)
38. Zeng, Z. B. (1993) Theoretical basis for separation of multiple linked gene effects in mapping quantitative trait loci. Proc. Natl. Acad. Sci. U. S. A. 90, 10972-10976 (Pubitemid 23354350)
39. Davis, R. C., Schadt, E. E., Smith, D. J., Hsieh, E. W., Cervino, A. C., van Nas, A., Rosales, M., Doss, S., Meng, H., Allayee, H., and Lusis, A. J. (2005) A genome-wide set of congenic mouse strains derived from DBA/2J on a C57BL/6J background. Genomics 86, 259-270 (Pubitemid 41096695)
40. Nadeau, J. H., Singer, J. B., Matin, A., and Lander, E. S. (2000) Analysing complex genetic traits with chromosome substitution strains. Nat. Genet. 24, 221-225 (Pubitemid 30132188)
41. Wade, C. M., Kulbokas, E. J., 3rd, Kirby, A. W., Zody, M. C., Mullikin, J. C., Lander, E. S., Lindblad-Toh, K., and Daly, M. J. (2002) The mosaic structure of variation in the laboratory mouse genome. Nature 420, 574-578
42. Yang, H., Bell, T. A., Churchill, G. A., and Pardo-Manuel de Villena, F. (2007) On the subspecific origin of the laboratory mouse. Nat. Genet. 39, 1100-1107
43. Frazer, K. A., Eskin, E., Kang, H. M., Bogue, M. A., Hinds, D. A., Beilharz, E. J., Gupta, R. V., Montgomery, J., Morenzoni, M. M., Nilsen, G. B., Pethiyagoda, C. L., Stuve, L. L., Johnson, F. M., Daly, M. J., Wade, C. M., and Cox, D. R. (2007) A sequence-based variation map of 8.27 million SNPs in inbred mouse strains. Nature 448, 1050-1053 (Pubitemid 47345584)
44. Tanimoto, K., Yoshiga, K., Eguchi, H., Kaneyasu, M., Ukon, K., Kumazaki, T., Oue, N., Yasui, W., Imai, K., Nakachi, K., Poellinger, L., and Nishiyama, M. (2003) Hypoxia-inducible factor-1alpha polymorphisms associated with enhanced transactivation capacity, implying clinical significance. Carcinogenesis 24, 1779-1783 (Pubitemid 37408141)
45. Iughetti, P., Suzuki, O., Godoi, P. H., Alves, V. A., Sertie, A. L., Zorick, T., Soares, F., Camargo, A., Moreira, E. S., di Loreto, C., Moreira-Filho, C. A., Simpson, A., Oliva, G., and Passos-Bueno, M. R. (2001) A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma. Cancer Res. 61, 7375-7378 (Pubitemid 32995018)
46. Balasubramanian, S. P., Cross, S. S., Globe, J., Cox, A., Brown, N. J., and Reed, M. W. (2007) Endostatin gene variation and protein levels in breast cancer susceptibility and severity. BMC Cancer 7, 107 (Pubitemid 47161702)
47. Kariyazono, H., Ohno, T., Khajoee, V., Ihara, K., Kusuhara, K., Kinukawa, N., Mizuno, Y., and Hara, T. (2004) Association of vascular endothelial growth factor (VEGF) and VEGF receptor gene polymorphisms with coronary artery lesions of Kawasaki disease. Pediatr. Res. 56, 953-959 (Pubitemid 39552779)
48. Shiozawa, S., Komai, K., Kawasaki, H., Sato, M., Nakatsukasa, M., Nakashima, T., Okayama, R., and Sakai, C. (2002) [The molecular genetics of rheumatoid arthritis disease gene]. Nippon Rinsho 60, 2269-2275
49. Topol, E. J., McCarthy, J., Gabriel, S., Moliterno, D. J., Rogers, W. J., Newby, L. K., Freedman, M., Metivier, J., Cannata, R., O'Donnell, C. J., Kottke-Marchant, K., Murugesan, G., Plow, E. F., Stenina, O., and Daley, G. Q. (2001) Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation 104, 2641-2644 (Pubitemid 33108126)
50. Ren, B., Yee, K. O., Lawler, J., and Khosravi-Far, R. (2006) Regulation of tumor angiogenesis by thrombospondin-1. Biochim. Biophys. Acta 1765, 178-188
51. Lobov, I. B., Renard, R. A., Papadopoulos, N., Gale, N. W., Thurston, G., Yancopoulos, G. D., and Wiegand, S. J. (2007) Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl. Acad. Sci. U. S. A. 104, 3219-3224 (Pubitemid 46364140)
52. Liu, X. B., Masago, R., Kong, L., Zhang, B. X., Masago, S., Vela-Roch, N., Katz, M. S., Yeh, C. K., Zhang, G. H., Talal, N., and Dang, H. (2000) G-protein signaling abnormalities mediated by CD95 in salivary epithelial cells. Cell Death Differ. 7, 1119-1126 (Pubitemid 30952846)
53. Suh, P. G., Hwang, J. I., Ryu, S. H., Donowitz, M., and Kim, J. H. (2001) The roles of PDZ-containing proteins in PLC-beta-mediated signaling. Biochem. Biophys. Res. Commun. 288, 1-7 (Pubitemid 32999717)
54. Wong, H. P., Yu, L., Lam, E. K., Tai, E. K., Wu, W. K., and Cho, C. H. (2007) Nicotine promotes colon tumor growth and angiogenesis through beta-adrenergic activation. Toxicol. Sci. 97, 279-287 (Pubitemid 47073845)
55. Kim, A. C., Peters, L. L., Knoll, J. H., Van Huffel, C., Ciciotte, S. L., Kleyn, P. W., and Chishti, A. H. (1997) Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse chromosome 19 and human chromosome 10q25, a region frequently deleted in human cancers. Genomics 46, 291-293 (Pubitemid 28013427)
56. Brannan, C. I., Disteche, C. M., Park, L. S., Copeland, N. G., and Jenkins, N. A. (2001) Autosomal telomere exchange results in the rapid amplification and dispersion of Csf2ra genes in wild-derived mice. Mamm. Genome 12, 882-886
57. Carroll, S., Lu, S., Herrera, A. H., and Horowits, R. (2004) N-RAP scaffolds I-Z-I assembly during myofibrillogenesis in cultured chick cardiomyocytes. J. Cell Sci. 117, 105-114 (Pubitemid 38072125)
58. Zheng, H., Ji, C., Zou, X., Wu, M., Jin, Z., Yin, G., Li, J., Feng, C., Cheng, H., Gu, S., Xie, Y., and Mao, Y. (2003) Molecular cloning and characterization of a novel human putative transmembrane protein homologous to mouse sideroflexin associated with sideroblastic anemia. DNA Seq. 14, 369-373
59. Reed, D. R., Li, X., McDaniel, A. H., Lu, K., Li, S., Tordoff, M. G., Price, R. A., and Bachmanov, A. A. (2003) Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains. Mamm. Genome 14, 302-313 (Pubitemid 36521063)
60. Smith, J. D., Bhasin, J. M., Baglione, J., Settle, M., Xu, Y., and Barnard, J. (2006) Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan. Arterioscler. Thromb. Vasc. Biol. 26, 597-603
61. Stylianou, I. M., Korstanje, R., Li, R., Sheehan, S., Paigen, B., and Churchill, G. A. (2006) Quantitative trait locus analysis for obesity reveals multiple networks of interacting loci. Mamm. Genome. 17, 22-36 (Pubitemid 43099502)
62. Tripodis, N., Hart, A. A., Fijneman, R. J., and Demant, P. (2001) Complexity of lung cancer modifiers: mapping of thirty genes and twenty-five interactions in half of the mouse genome. J. Natl. Cancer Inst. 93, 1484-1491 (Pubitemid 32982678)
63. Higashi, S., Murai, T., Mori, S., Kamoto, T., Yoshitomi, M., Arakawa, Y., Makino, S., Fukushima, S., Yoshida, O., and Hiai, H. (1998) Host genes affecting survival period of chemically induced bladder cancer in mice. J. Cancer Res. Clin. Oncol. 124, 670-676 (Pubitemid 29003299)
64. Mountz, J. D., Yang, P., Wu, Q., Zhou, J., Tousson, A., Fitzgerald, A., Allen, J., Wang, X., Cartner, S., Grizzle, W. E., Yi, N., Lu, L., Williams, R. W., and Hsu, H. C. (2005) Genetic segregation of spontaneous erosive arthritis and generalized autoimmune disease in the BXD2 recombinant inbred strain of mice. Scand. J. Immunol. 61, 128-138 (Pubitemid 40255356)
65. Otto, J. M., Cs-Szabo, G., Gallagher, J., Velins, S., Mikecz, K., Buzas, E. I., Enders, J. T., Li, Y., Olsen, B. R., and Glant, T. T. (1999) Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Arthritis Rheum. 42, 2524-2531 (Pubitemid 30327168)
66. Cherrington, J. M., Strawn, L. M., and Shawver, L. K. (2000) New paradigms for the treatment of cancer: the role of antiangiogenesis agents. Adv. Cancer Res. 79, 1-38
67. Kerbel, R., and Folkman, J. (2002) Clinical translation of angiogenesis inhibitors. Nat. Rev. Cancer 2, 727-739
68. Rupnick, M. A., Panigrahy, D., Zhang, C. Y., Dallabrida, S. M., Lowell, B. B., Langer, R., and Folkman, M. J. (2002) Adipose tissue mass can be regulated through the vasculature. Proc. Natl. Acad. Sci. U. S. A. 99, 10730-10735 (Pubitemid 34907045)
69. Yano, K., Brown, L. F., and Detmar, M. (2001) Control of hair growth and follicle size by VEGF-mediated angiogenesis. J. Clin. Invest. 107, 409-417 (Pubitemid 32167987)
70. Smith, S. K. (2001) Angiogenesis and reproduction. BJOG 108, 777-783
71. McLaren, J. (2000) Vascular endothelial growth factor and endometriotic angiogenesis. Hum. Reprod. Update 6, 45-55 (Pubitemid 30099342)
72. Shaked, Y., Bertolini, F., Man, S., Rogers, M. S., Cervi, D., Foutz, T., Rawn, K., Voskas, D., Dumont, D. J., Ben-David, Y., Lawler, J., Henkin, J., Huber, J., Hicklin, D. J., D'Amato, R. J., and Kerbel, R. S. (2005) Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis. Cancer Cell 7, 101-111 (Pubitemid 40126386)
73. Gorin, M. B., Breitner, J. C., De Jong, P. T., Hageman, G. S., Klaver, C. C., Kuehn, M. H., and Seddon, J. M. (1999) The genetics of age-related macular degeneration. Mol. Vis. 5, 29
74. Weeks, D. E., Conley, Y. P., Tsai, H. J., Mah, T. S., Schmidt, S., Postel, E. A., Agarwal, A., Haines, J. L., Pericak-Vance, M. A., Rosenfeld, P. J., Paul, T. O., Eller, A. W., Morse, L. S., Dailey, J. P., Ferrell, R. E., and Gorin, M. B. (2004) Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions. Am. J. Hum. Genet. 75, 174-189 (Pubitemid 38943862)
75. Barral, S., Francis, P. J., Schultz, D. W., Schain, M. B., Haynes, C., Majewski, J., Ott, J., Acott, T., Weleber, R. G., and Klein, M. L. (2006) Expanded genome scan in extended families with age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 47, 5453-5459 (Pubitemid 46723797)
76. Cheverud, J. M., Routman, E. J., Duarte, F. A., van Swinderen, B., Cothran, K., and Perel, C. (1996) Quantitative trait loci for murine growth. Genetics 142, 1305-1319 (Pubitemid 26115510)
77. Masinde, G. L., Li, X., Gu, W., Davidson, H., Hamilton-Ulland, M., Wergedal, J., Mohan, S., and Baylink, D. J. (2002) Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. Funct. Integr. Genomics 2, 98-104 (Pubitemid 41399308)
78. Masinde, G. L., Li, X., Gu, W., Hamilton-Ulland, M., Mohan, S., and Baylink, D. J. (2002) Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice. Funct. Integr. Genomics. 2, 120-125 (Pubitemid 41399310)
79. Taylor, B. A., Wnek, C., Schroeder, D., and Phillips, S. J. (2001) Multiple obesity QTLs identified in an intercross between the NZO (New Zealand obese) and the SM (small) mouse strains. Mamm. Genome 12, 95-103 (Pubitemid 32147663)
80. Taylor, B. A., and Phillips, S. J. (1997) Obesity QTLs on mouse chromosomes 2 and 17. Genomics 43, 249-257
81. Kenney-Hunt, J. P., Vaughn, T. T., Pletscher, L. S., Peripato, A., Routman, E., Cothran, K., Durand, D., Norgard, E., Perel, C., and Cheverud, J. M. (2006) Quantitative trait loci for body size components in mice. Mamm. Genome 17, 526-537 (Pubitemid 43911474)
82. Symons, R. C., Daly, M. J., Fridlyand, J., Speed, T. P., Cook, W. D., Gerondakis, S., Harris, A. W., and Foote, S. J. (2002) Multiple genetic loci modify susceptibility to plasmacytoma-related morbidity in E(mu)-v-abl transgenic mice. Proc. Natl. Acad. Sci. U. S. A. 99, 11299-11304 (Pubitemid 34920920)
83. Ghazalpour, A., Doss, S., Zhang, B., Wang, S., Plaisier, C., Castellanos, R., Brozell, A., Schadt, E. E., Drake, T. A., Lusis, A. J., and Horvath, S. (2006) Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet. 2, e130 (Pubitemid 44298493)
84. Brown, A. C., Olver, W. I., Donnelly, C. J., May, M. E., Naggert, J. K., Shaffer, D. J., and Roopenian, D. C. (2005) Searching QTL by gene expression: analysis of diabesity. BMC Genet. 6, 12