Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis

Arthritis and Rheumatism

Volumn 42, Issue 12, 1999, Pages 2524-2531

  Otto, Jeffrey M ^a   Cs Szabó, Gabriella ^a   Gallagher, Jodi ^a   Velins, Sonja ^a   Mikecz, Katalin ^a   Buzás, Edit I ^b   Enders, Jill T ^a   Li, Yefu ^c   Olsen, Björn R ^d   Glant, Tibor T ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; CHROMOSOMAL LOCALIZATION; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENE FUNCTION; GENE ISOLATION; GENE LOCUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RHEUMATOID ARTHRITIS; STRAIN DIFFERENCE;

ANIMALS; ANTIBODY FORMATION; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 7; DISEASE MODELS, ANIMAL; FEMALE; GENES, MHC CLASS I; GENES, MHC CLASS II; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED DBA;

EID: 0033499482     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199912)42:12<2524::AID-ANR4>3.0.CO;2-0     Document Type: Article

References (25)

1. Hasstedt SJ, Clegg DO, Ingles L, Ward RH. HLA-linked rheumatoid arthritis. Am J Hum Genet 1994;55:738-46.
2. Hardwick LJ, Walsh S, Butcher S, Nicod A, Shatford J, Bell J, et al. Genetic mapping of susceptibility loci in the genes involved in rheumatoid arthritis. J Rheumatol 1997;24:197-8.
3. Khan MA. Spondylarthropathies. Curr Opin Rheumatol 1994;6: 351-3.
4. David CS. The mystery of HLA-B27 and disease. Immunogenetics 1998;46:73-7.
5. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice: clinical features and histopathology. Arthritis Rheum 1987;30:201-12.
6. Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B. Immunization against heterologous type II collagen induces arthritis in mice. Nature 1980;282:666-8.
7. Zhang Y, Guerassimov A, Leroux J-Y, Cartman A, Webber C, Lalic R, et al. Induction of arthritis in BALB/c mice by cartilage link protein: involvement of distinct regions recognized by T-and B lymphocytes. Am J Pathol 1998;153:1283-91.
8. Verheijden GFM, Rijnders AWM, Bos E, Coenen-de Roo CJJ, van Staveren CJ, Miltenburg AMM, et al. Human cartilage glycoprotein-39 as a candidate autoantigen in rheumatoid arthritis. Arthritis Rheum 1997;40:1115-25.
9. Mikecz K, Glant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum 1987;30:306-18.
10. Mikecz K, Brennan FR, Kim JH, Glant TT. Anti-CD44 treatment abrogates tissue edema and leukocyte infiltration in murine arthritis. Nat Med 1995;1:558-63.
11. Glant TT, Buzás El, Finnegan A, Negroiu G, Cs-Szabó G, Mikecz K. Critical role of glycosaminoglycan side chains of cartilage proteoglycan (aggrecan) in antigen recognition and presentation. J Immunol 1998;160:3812-9.
12. Glant TT, Cs-Szabó G, Nagase H, Jacobs JJ, Mikecz K. Progressive polyarthritis induced in BALB/c mice by aggrecan from normal and osteoarthritic human cartilage. Arthritis Rheum 1998; 41:1007-18.
13. Lander ES, Green P, Abrahamson J, Barlow A, Daly MJ, Lincoln SE, et al. MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations. Genomics 1987;1:174-81.
14. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics 1995;138:1421-8.
15. Remmers EF, Longman RE, Du Y, O'Hare A, Cannon GW, Griffiths MM, et al. A genome scan localizes five non-MHC loci controlling collagen-induced arthritis in rats. Nat Genet 1996;14: 82-5.
16. lpr mice. J Clin Invest 1998;101:696-702.
17. Kawahito Y, Cannon GW, Gulko PS, Remmers EF, Longman RE, Reese VR, et al. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J Immunol 1998;161: 4411-9.
18. Vingsbo-Lundberg C, Nordquist N, Olofsson P, Sundvall M, Saxne T, Pettersson U, et al. Genetic control of arthritis onset, severity and chronicity in a model for rheumatoid arthritis in rats. Nat Genet 1998;20:401-4.
19. Dahlman I, Jacobsson L, Glaser A, Lorentzen JC, Andersson M, Luthman H, et al. Genome-wide linkage analysis of chronic relapsing experimental autoimmune encephalomyelitis in the rat identifies a major susceptibility locus on chromosome 9. J Immunol 1999;162:2581-8.
20. Cornélis F, Fauré S, Martinez M, Prud'homme JF, Fritz P, Dib C, et al. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA 1998;95: 10746-50.
21. Shaw MJ, Clayton D, Atkinson SE, Williams H, Miller N, Sibthorpe D, et al. Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35. J Med Genet 1996;33:672-7.
22. Roth MP, Viratelle C, Dolbois L, Delverdier M, Borot N, Pelletier L, et al. A genome-wide search identifies two susceptibility loci for experimental autoimmune encephalomyelitis on rat chromosomes 4 and 10. J Immunol 1999;162:1917-22.
23. Sundvall M, Jirholt J, Yang H-T, Jansson L, Engström A, Pettersson U, et al. Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis. Nat Genet 1995;10:313-7.
24. Brown MA, Pile KD, Kennedy LG, Campbell D, Andrew L, March R, et al. A genome-wide screen for susceptibility loci in ankylosing spondylitis. Arthritis Rheum 1998;41:588-95.
25. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995;11:241-7.