Role of vitamin E in cellular antioxidant defense

Current Chemical Biology

Volumn 3, Issue 2, 2009, Pages 197-202

  Chow, Ching Kuang ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Labile iron; Mitochondria; Superoxide; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; FERRITIN; FREE RADICAL; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; PEROXYNITRITE; POLYUNSATURATED FATTY ACID; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TRANSFERRIN; UBIDECARENONE; XANTHINE OXIDASE;

ALPHA TOCOPHEROL DEFICIENCY; ANTIOXIDANT ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME SYNTHESIS; GENE EXPRESSION; LIPID PEROXIDATION; LIPID SOLUBILITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; REVIEW; TISSUE INJURY; TISSUE LEVEL; VITAMIN SUPPLEMENTATION;

EID: 68449088115     PISSN: 18723136     EISSN: None     Source Type: Journal    
DOI: 10.2174/187231309788166406     Document Type: Review

References (91)

1. Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996; 31: 671-701.
2. Chow CK. Vitamin E. In: Rucker RB, Suttie JW, McCormick DB, Machlin LJ, Eds, Handbook of Vitamins, 3rd ed., New York, Marcel Dekker, 2001; 165-97.
3. Evans HM, Bishop KS. On the existence of a hitherto unrecognized dietary factor essential for reproduction. Science 1922; 56: 650-1.
4. Scott ML. Studies on vitamin E and related factors in nutrition and metabolism. In: DeLuca HF, Suttie JW, Eds, The Fat-Soluble Vitamins. Madison, University of Wisconsin Press, 1969; 355-68.
5. Bieri JG, Farrell PM. Vitamin E. Vit Horm 1976; 34: 31-75.
6. Kohlschutter A, Hubner C, Jansen W, Lindner SG. A treatable familial neuromyopathy with vitamin E deficiency, normal absorption, and evidence of increased consumption of vitamin E. J Inher Metab Dis 1988; 11: 149-52.
7. Arita M, Sato Y, Miyata A, et al. Human -tocopherol transfer protein: gene structure and chromosomal localization. Biochem J 1995; 305: 437-43.
8. Quahchi K, Arita M, Kayden HJ, et al. Ataxia with isolated vitamin E deficiency is caused by mutation in the -tocopherol transfer protein. Nature Genetics 1995; 9: 141-5.
9. Etminan M, Gill SS, Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol 2005; 4: 362-5.
10. Pham DQ, Plakoqiannis R. Vitamin E supplementation in cardiovascular disease and cancer prevention: Part 1. Ann Pharmacother 2005; 39: 1870-8.
11. Pham DQ, Plakoqiannis R. Vitamin E supplementation in Alzheimer's disease, Parkinson's disease, tardive dyskinesia, and cataract: Part 2. Ann Pharmacither 2005; 39: 2065-72.
12. Cook NR, Gaziano JM, Gardon D, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. J Am Med Assoc 2005; 294: 56-65.
13. Eidelman RS, Hollar D, Hebert PR, Lamas GA, Hennekens CH. Randomized trials of vitamin E in the treatment and prevention of cardiovascular disease. Arch Int Med 2004; 164: 1552-6.
14. Berman K, Brodaty H. Tocopherol [vitamin E] in Alzheimer's disease and other neurodegenerative disorders. CNS Drug 2004; 18: 807-25.
15. Upston JM, Kritharides L, Stocker R. The role of vitamin E in atherosclerosis. Prog Lipid Res 2003; 42: 405-22.
16. Jialal I, Devaraj S. Scientific evidence to support a vitamin E and heart disease health claim: research needs. J Nutr 2005; 135: 348-53.
17. Trumbo PR. The level of evidence for permitting a qualified health claim: FDA's review of the evidence for selenium and cancer and vitamin E and heart disease. J Nutr 2005; 135: 354-6.
18. Brigelius-Flohe R, Kelly FJ, Salonen JT, Neuzil J, Zingg JM, Azzi A. The European perspective on vitamin E: current knowledge and future research. Am J Clin Nutr 2002; 76: 703-16.
19. Azzi A. Molecular mechanism of -tocopherol action. Free Rad Biol Med 2007; 43: 16-21.
20. Niki E. Vitamin E function. Free-Rad Biol Med 2007; 43: 1466-7.
21. Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Rad Biol Med 2007; 43: 4-15.
22. Chow CK. Vitamin E and oxidative stress. Free Rad Biol Med 1991; 11: 215-32.
23. Chow CK. Nutritional influence in cellular antioxidant defense systems. Am J Clin Nutr 1979; 32: 1066-81.
24. Yu BP. Cellular defense against damage from reactive oxygen species. Physiol Rev 1994; 74: 139-62.
25. Sies H. Biochemistry of oxidative stress. Angew Chem Int Ed Eng 1986; 25: 1058-71.
26. Freeman BA, Crapo JD. Biology of disease: free radicals and tissue injury. Lab Invest 1982; 47: 412-26.
27. Squadrito GL, Pryor WA: Oxidative chemistry on nitric oxide: The roles of superoxide, peroxynitrite, and cartbon dioxide. Free Rad Biol Med 1998; 25: 392-403.
28. Lenaz, G. Role of mitochondria in oxidative stress and aging. Biochim Biophys Acta 1998; 1366: 53-67.
29. Wallace DC, Brown MD, Melov S, Graham B, Lott M. Mitochondrial biology, degenerative disease and aging. Biofactors 1998; 7: 187-90.
30. Fukuzawa K, Gebicki JM. Oxidation of α-tocopherol in micelles and liposomes by hydroxyl, perhydroxyl and superoxide free radicals. Arch Biochem Biophys 1983; 226: 242-51.
31. Olcott HS, Van der Veen J. Comparative antioxidant activities of toco and its methyl derivatives. Lipids 1968; 3: 331-3.
32. Burton GW, Traber MG. Vitamin E: Antioxidant activity, biokinetics, and bioavailability. Ann Rev Nutr 1990; 10: 357-80.
33. Pokprny J. Major factors affecting the autoxidation of lipids. In: Chan HWS, Ed, Autoxidation of Unsaturated Lipids, London, Academic Press, 1987; 141-206.
34. Cracowski JL, Girolet S, Imbert B, et al. Effects of short-term treatment with vitamin E in systemic sclerosis: a double blind, randomized, controlled clinical trial of efficacy based on urinary isoprostane measurement. Free Rad Biol Med 2005; 38: 98-103.
35. Chow CK, Tappel AL. An enzymatic protective mechanism against lipid peroxidation damage to lungs of ozone-exposed rats. Lipids 1972; 7: 518-24.
36. Chan AC, Tran K, Raynor T, Ganz PR, Chow CK. Regeneration of vitamin E in human platelets. J Biol Chem 1991; 266: 17290-95.
37. Packer JE, Slater TF, Wilson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature 1979; 278: 737-8.
38. Diliberto E, Jr, Dean G, Carter C, Allen PL. Tissue, subcellular and submitochondrial distributions of semidehydroascorbaye reductase: possible role of semidehydroascorbate reductase in cofactor regeneration. J Neurochem 1982; 39: 563-8.
39. Niki E, Tsuchiya J, Tanimura R, Kamiya Y. Regeneration of vitamin E from alpha-chromanoxy radical by glutathione and vitamin C. Chem Lett 1982; 789-92.
40. Bertinato J, Hidiroglou N, Peace R, et al. Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues. Nutr J 2007; 6: 7 open access.
41. Smith P, Tappel AL, Chow CK. Glutathione peroxidase activity as a function of dietary selenomethionine. Nature 1974; 247: 392-3.
42. Ursini F, Maiorino M, Gregolin C. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim Biophys Acta 1985; 839: 62-70.
43. Imai H, Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase PHGPx, GPx4 in mammalian cells. Free Rad Biol Med 2003; 34: 145-69.
44. Chow CK, Reddy K, Tappel AL. Effect of dietary vitamin E on the activities of glutathione peroxidase system in rat tissue. J Nutr 1973; 103: 618-24.
45. Chow CK. Biochemical responses in the lungs of ozone-tolerant rats. Nature 1976; 260: 721-2.
46. Chow CK. Effect of dietary vitamin E and selenium on rats: Pyruvate kinase, glutathione peroxidase and oxidative damage. Nutr Res 1990; 10: 183-94.
47. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Nat Acad Sci USA 1994; 91: 10771-8.
48. Bjorneboe A, Nenseter MS, Hagen BF, Aa. Bjorneboe GE, Prydz K, Drevon CA. Effect of dietary deficiency and supplement with all-rac-alpha-tocopherol on hepatic content in rats. J Nutr 1991; 121: 1208-13.
49. Thomas PK, Cooper JM, King RH, et al. Myopathy in vitamin E deficient rats: muscle fiber necrosis associated with disturbances of mitochondrial function. J Anat 1993; 183: 451-61.
50. Catignani GL, Chytil F, Darby WJ. Vitamin E deficiency: immunochemical evidence for increased accumulation of liver xanthine oxidase. Proc Nat Acad Sci USA 1974; 71: 1966-8.
51. Masugi F, Nakamura T. Effect of vitamin E deficiency on the level of superoxide dismutase, glutathione peroxidase, catalase and lipid peroxide in rat liver. Internat J Vit Nutr Res 1976; 46: 187-91.
52. Chow CK, Ibrahim W, Wei Z, Chan AC. Vitamin E regulates mitochondrial hydrogen peroxide generation. Free Rad Biol Med 1999; 27: 580-7.
53. Lass A, Sohal RS. Effect of coenzyme Q[10] and alpha-tocopherol content of mitochondria on the production of superoxide anion radicals. FASEB J 2000; 14: 87-94.
54. Castilla P, Davalos A, Teruel JL, et al. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. Am J Clin Nutr 2008; 87: 1053-61.
55. Chow CK. Vitamin E regulation of mitochondrial superoxide. Biol Signals Receptors 2001; 10: 112-24.
56. Welch KD, Davis TZ, Van-Eden ME, Aust SD. Deleterious iron-mediated oxidation of biomolecules. Free Rad Biol Med 2002; 32: 577-83.
57. Aust SD, Chignell CF, Bray TM, Kalyanaraman B, Mason RP. Free radicals in toxicology. Toxicol Appl Pharmacol 1993; 120: 168-78.
58. Minotti G, Aust SD. The requirement for iron [III] in the initiation of lipid peroxidation by iron [II] and hydrogen peroxide. J Biol Chem 1987; 262: 1098-104.
59. Balcerczyk A, Kruszewski M, Bartosz G. Does the cellular labile iron pool participate in the oxidation of 2′,7′-dichlorodihydrofluorescein? Free Rad Res 2007; 41: 563-70.
60. Afanas'ev IB. Superoxide and nitric oxide in pathological conditions associated with iron overload: the effects of antioxidants and chelators. Curr Med Chem 2005; 12: 2731-9.
61. Emerit J, Beaumont C, Trivin F. Iron metabolism, free radicals, and oxidative injury. Biomed Pharmacother 2001; 55: 333-9.
62. Kabat GC, Rohan TE. Does excess iron play a role in breast carcinogenesis? An unresolved hypothesis. Cancer Causes Control 2007; 18: 1047-53.
63. Minotti G. Sources and role of iron in lipid peroxidation. Chem Res Toxicol 1993; 6: 134-6.
64. Minotti G, Aust SD. Redox cycling of iron and lipid peroxidation. Lipids 1992; 27: 219-26.
65. Agrawal R, Sharma PK, Rao GS. Release of iron from ferritin by metabolites of benzene and superoxide radical generating agents. Toxicology 2001; 168: 223-30.
66. Keyer K, Imlay JA. Superoxde accelerates DNA damage by elevating free iron levels. Proc Natl Acad Sci USA 1996; 93: 13635-40.
67. Selim MH, Ratan RR. The role of iron neurotoxicity in ischemic stroke. Ageing Res Rev 2004; 3: 345-53.
68. Kakhlon O, Ioav Cabantchik Z. The labile iron pool: characterization, measurement, and participation in cellular processes. Free Rad Biol Med 2002; 33: 1037-46.
69. Chou AC, Broun GO, Fitch CD Jr. Abnormalities of iron metabolism and erythropoieses in vitamin E-deficient rabbits. Blood 1978; 52: 187-95.
70. Fraga CG, Oteiza P. Iron toxicity and antioxidant nutrients. Toxicology 2002; 180: 23-32.
71. Ibrahim W, Chow CK. Dietary vitamin E reduces tissue labile iron. J Biochem Mol Toxicol 2005; 19: 298-303.
72. Ibrahim W, Chow CK. Unpublished results.
73. Rimbach G, Minihane AM, Majewicz J, et al. Regulation of cell signalling by vitamin E. Proc Nutr Soc 2002; 61: 415-25.
74. Azzi A, Gysin R, Kempna P, et al. Vitamin E mediates cell signaling and regulation of gene expression. Ann NY Acad Sci 2004; 1031: 86-95.
75. Tucker JM, Townsend DM. Alpha-tocopherol: role in prevention and therapy of human disease. Biomed Pharmacother 2005; 59: 380-7.
76. Tasinato A, Boscoboinik D, Bartoli GM, Maroni P, Azzi A. D-Alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci USA 1995; 92: 12190-4.
77. Lee PJ, Choi AM. Pathways of cell signaling in hyperoxia. Free Rad Biol Med 2003; 35: 341-50.
78. O'Donnell VB. Free radicals and lipid signaling in endothelial cells. Antioxid Redox Signal 2003; 5: 195-200.
79. Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol 2003; 5: 247-54.
80. von Harsdorf R, Li PF, Dietz R. Signaling pathways in reactive oxygen species-induced cardiomyocyte apoptosis. Circulation 1999; 99: 2934-41.
81. Ushakova T, Melkonyan H, Nikonova L, et al. Modification of gene expression by dietary antioxidants in radiation-induced apoptosis of mice splenocytes. Free Rad Biol Med 1999; 26: 887-91.
82. Haddad JJ. Antioxidant and prooxidant mechanisms in the regulation of redox[y]-sensitive transcription factors. Cell Signal 2002; 14: 879-97.
83. Touyz RM. Recent advances in intracellular signaling in hypertension. Curr Opin Nephrol Hypertens 2003; 12: 165-74.
84. Chiarugi P. Reactive oxygen species as mediators of cell adhesion. Ital J Biochem 2003; 52: 28-32.
85. Du Y, Miller CM, Kern TS. Hyperglycemia increases mitochondrial superoxide in retina and retinal cells. Free Rad Biol Med 2003; 35: 1491-9.
86. Shen HM, Liu ZG. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Rad Biol Med 2006; 40; 928-39.
87. Tagami M, Yamagata K, Ikeda K, et al. Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion. Lab Invest 1998; 78: 1415-29.
88. Freedman JE, Farhat jh, Loscalzo J, Keaney JF Jr. Alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation 1996; 94: 2434-40.
89. Koya D, Haneda M, Kikkawa R, King GL. D-Alpha-tocopherol treatment prevents glomerular dysfunctions in diabetic rats through inhibition of protein kinase C-diacylglycerol pathway. Biofactors 1998; 7: 69-76.
90. Yano M, Kishida E, Iwasaki M, Kojo S, Masuzawa Y. Docosahexaenoic acid and vitamin E can reduce human monocytic U937 cell apoptosis induced by tumor necrosis factor. J Nutr 2000; 130: 1095-101.
91. Sylvester PW. Vitamin E and apoptosis. Vitam Horm 2007; 76: 329-56.