N-substituted bis-C-alkyloxadiazolones as dual effectors: Efficient intermediates to amidoximes or amidines and prodrug candidates of potent antimalarials

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5233-5236

  Degardin, Mélissa ^a   Wein, Sharon ^b   Durand, Thierry ^a   Escale, Roger ^a   Vial, Henry ^b   Vo Hoang, Yen ^a  

^a UNIVERSITÉ DE MONTPELLIER   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

Alkylamidoxime; Bis C alkylamidine; Convenient route; Design of prodrug candidates; N substituted alkyloxadiazolone; Oral antimalarial agent; Total clearance of parasitemia

Indexed keywords

AMIDINE; AMIDOXIME; ANTIMALARIAL AGENT; OXADIAZOLONE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FOURIER TRANSFORMATION; MALARIA; MALARIA FALCIPARUM; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE;

AMIDINES; ANIMALS; ANTIMALARIALS; FEMALE; MICE; OXADIAZOLES; OXIMES; PLASMODIUM; PRODRUGS;

EID: 68349158680     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.001     Document Type: Article

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