Synthetic [5,5] trans-fused indane lactones as inhibitors of thrombin

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 3, 1999, Pages 431-436

  Pass, Martin ^a   Bolton, Richard E ^a   Coote, Steven J ^a   Finch, Harry ^a   Hindley, Sean ^a   Lowdon, Andrew ^a   McDonald, Edward ^a   McLaren, Jessica ^a   Owen, Martin ^a   Pegg, Neil A ^a   Mooney, Christopher J ^a   Tang, Chi Man ^a   Parry, Simon ^a   Patel, Champa ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INDAN DERIVATIVE; LACTONE DERIVATIVE; SERINE PROTEINASE; THROMBIN; THROMBIN INHIBITOR;

ANTICOAGULATION; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTICOAGULANTS; ANTITHROMBINS; HUMANS; INDANS; KINETICS; LACTONES; PARTIAL THROMBOPLASTIN TIME;

EID: 0033535082     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00002-5     Document Type: Article

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14. PPACK is D-Phe-Pro-Arg-chloromethylketone
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16. For convenience we have retained the indane numbering system throughout.
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18. Trypsin amino acid numbering is used.