4,5-Diphenyltriazol-3-ones: Openers of large-conductance Ca2+-activated potassium (maxi-K) channels

Journal of Medicinal Chemistry

Volumn 45, Issue 14, 2002, Pages 2942-2952

  Romine, Jeffrey L ^a   Starrett Jr , John E ^a   Martin, Scott W ^a   Gribkoff, Valentin K ^a   Boissard, Christopher G ^a   Dworetzky, Steven I ^a   Natale, Joanne ^a   Li, Yi ^a   Gao, Qi ^a   Meanwell, Nicholas A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 CHLORO 2 HYDROXYPHENYL) 5 TRIFLUOROMETHYL 2 BENZIMIDAZOLONE; 4 (5 CHLORO 2 HYDROXYPHENYL) 5 [3,5 BIS(TRIFLUOROMETHYL)PHENYL] 2,4 DIHYDRO 3H 1,2,4 TRIAZOL 3 ONE; 4,5 DIPHENYLTRIAZOL 3 ONE DERIVATIVE; POTASSIUM CHANNEL; POTASSIUM CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONDUCTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; XENOPUS LAEVIS;

EID: 0037019278     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010569q     Document Type: Article

References (35)

1. Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress
2. Potassium channel activator drugs: Mechanism of action, pharmacological properties, and therapeutic potential
3. Neuropharmacology of potassium ion channels
4. Potassium channel openers and vascular smooth muscle relaxation
5. Modulation of potassium channels by organic molecules
6. The pharmacology and molecular biology of large-conductance calcium-activated (maxi-K) potassium channels
7. Modulators of large-conductance calcium-activated potassium (maxi-K) channels as potential therapeutic targets
8. + channels in rat brain: Targeting to axons and nerve terminals
9. Recently developed neuroprotective therapies for acute stroke
10. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
11. Opening of large-conductance calcium-activated potassium channels by the substituted benzimidazole NS004
12. + channels in cerebellar granule cells
13. + channels by novel benzimidazolone
14. + channels
15. + channels
16. mSlo, a complex mouse gene encoding "Maxi" calcium-activated potassium channels
17. Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
18. Synthesis and structure-activity relationships of 3-aryloxyindoles: New class of calcium-dependent, large conductance potassium (Maxi-K) channel openers with neuroprotective properties
19. The discovery of novel openers of Ca2+-dependent large-conductance potassium channels: Pharmacophore search and physiological evaluation of flavonoids
20. Nonprostanoid prostacyclin mimetics. 3. Structural variations of the diphenyl heterocycle moiety
21. Reactions of amidrazones with ethyl chloroformate. Synthesis of 3,4-diaryl-substituted 1,2,4-triazol-5-ones
22. On Cyclocondensations with open-chain Amidrazones
23. The synthesis of morphine
24. Synthesis of substituted N-(2,4-dioxo-1,2,3,4-tetrahydroquinazolinyl)benzamides and N-(2-thiono-4-oxo-1,2,3,4-tetrahydorquinazolinyl)benzamides
25. 2,4-Dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents
26. Demethylation of aryl methyl ethers by boron tribromide
27. Synthesis of an imidazo[1,2-c]pyrimidine analogue of a thiamine antagonist coccidiostat and a comparison of several methods for the preparation of imidazo[1,2-c]pyrimidines
28. Base-induced cycloaddition of sulfonylmethyl isocyanides to C, N double bonds. Synthesis of 1,5-disubstituted and 1,4,5-trisubstituted imidazoles from aldimines and imidoyl chlorides
29. Synthesis of oxazoles, imidazoles, and pyrroles with the use of monosubstituted tosylmethyl isocyanides
30. The metalation of 1-methyl, 1-benzyl, and 1-phenylimidazole with n-butyllithium
31. Investigations on the synthesis of new tricyclic heterocycles from 1,4-benzoxazines and 1,4-benzothiazine-3-oximes. Communications of the chemistry of O,N- and S,N-containing heterocycles