Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5186-5190

  Ando, Makoto ^a   Sekino, Etsuko ^a   Haga, Yuji ^a   Moriya, Minoru ^a   Ito, Masahiko ^a   Ito, Junko ^a   Iwaasa, Hisashi ^a   Ishihara, Akane ^a   Kanatani, Akio ^a   Ohtake, Norikazu ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anti obesity; Melanin concentrating hormone 1 receptor antagonist; Phenethylpyridone

Indexed keywords

MELANIN CONCENTRATING HORMONE RECEPTOR 1; MELANIN CONCENTRATING HORMONE RECEPTOR 1 ANTAGONIST; PHENETHYLPYRIDONE DERIVATIVE; PYRIDONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; IC 50; MOLECULAR STABILITY; MOUSE; NONHUMAN; REACTION ANALYSIS; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-OBESITY AGENTS; CHO CELLS; CRICETINAE; CRICETULUS; DRUG DISCOVERY; HUMANS; MICE; MICROSOMES, LIVER; PYRIDONES; RECEPTORS, SOMATOSTATIN; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 68349152495     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.023     Document Type: Article

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